| Name | Description | Molecular Function | Cellular Component | Biological Process |
|---|
| CD42C |
platelet glycoprotein IB beta chain precursor (GP-IB beta) (from PhosphoBase) |
transmembrane receptor activity,
protein binding |
integral to membrane,
integral to plasma membrane,
platelet alpha granule membrane |
platelet activation,
blood coagulation,
cell surface receptor linked signaling pathway,
cell adhesion |
| CD45 |
Receptor tyrosine phosphatase |
protein tyrosine phosphatase activity,
heparan sulfate proteoglycan binding,
protein kinase binding,
heparin binding,
transmembrane receptor protein tyrosine phosphatase activity |
external side of plasma membrane,
membrane raft,
focal adhesion,
integral to plasma membrane |
positive regulation of MAPKKK cascade,
regulation of S phase,
immunoglobulin biosynthetic process,
positive thymic T cell selection,
defense response to virus,
protein amino acid dephosphorylation,
positive regulation of antigen receptor-mediated signaling pathway,
positive regulation of apoptosis,
release of sequestered calcium ion into cytosol,
activation of MAPK activity,
negative regulation of T cell mediated cytotoxicity,
positive regulation of humoral immune response mediated by circulating immunoglobulin,
T cell receptor signaling pathway,
regulation of B cell receptor signaling pathway,
T cell proliferation,
heterotypic cell-cell adhesion,
negative regulation of protein amino acid autophosphorylation,
B cell differentiation,
positive regulation of isotype switching to IgG isotypes,
positive regulation of T cell mediated cytotoxicity,
positive regulation of B cell proliferation,
B cell receptor signaling pathway,
regulation of cell cycle,
positive regulation of alpha-beta T cell proliferation,
negative regulation of peptidyl-tyrosine phosphorylation,
positive regulation of gamma-delta T cell differentiation,
negative regulation of protein kinase activity,
negative thymic T cell selection,
regulation of B cell differentiation,
B cell proliferation,
negative regulation of cytokine-mediated signaling pathway,
leukocyte cell-cell adhesion |
| CD44 |
CD antigen |
collagen binding,
hyaluronic acid binding,
receptor activity,
receptor signaling protein activity |
external side of plasma membrane,
basolateral plasma membrane,
integral to plasma membrane |
branching involved in ureteric bud morphogenesis,
positive regulation of peptidyl-tyrosine phosphorylation,
positive regulation of ERK1 and ERK2 cascade,
branching involved in prostate gland morphogenesis,
positive regulation of peptidyl-serine phosphorylation,
negative regulation of DNA damage response, signal transduction by p53 class mediator,
cell-matrix adhesion,
cell-cell adhesion,
negative regulation of apoptosis,
wound healing involved in inflammatory response,
cell adhesion,
positive regulation of gene expression |
| CD4 |
coreceptor activity, extracellular matrix structural constituent |
MHC class II protein binding,
transmembrane receptor activity,
coreceptor activity,
extracellular matrix structural constituent,
protein homodimerization activity,
protein kinase binding,
glycoprotein binding,
zinc ion binding |
T cell receptor complex,
integral to membrane,
endoplasmic reticulum membrane,
early endosome |
induction by virus of host cell-cell fusion,
positive regulation of protein kinase activity,
maintenance of protein location in cell,
positive regulation of interleukin-2 biosynthetic process,
protein amino acid palmitoleylation,
initiation of viral infection,
transmembrane receptor protein tyrosine kinase signaling pathway,
T cell selection,
immune response,
cell adhesion |
| CD40 |
enzyme binding, receptor activity |
enzyme binding,
receptor activity |
extracellular region,
external side of plasma membrane,
integral to membrane,
integral to plasma membrane,
intracellular membrane-bounded organelle |
inflammatory response,
positive regulation of interleukin-12 production,
platelet activation,
positive regulation of isotype switching to IgG isotypes,
positive regulation of B cell proliferation,
protein complex assembly,
positive regulation of I-kappaB kinase/NF-kappaB cascade,
immune response-regulating cell surface receptor signaling pathway,
B cell activation,
B cell proliferation,
regulation of immunoglobulin secretion |
| PDCD4 |
Programmed cell death 4 |
RNA binding,
protein binding |
cytosol,
nucleus |
apoptosis,
negative regulation of JUN kinase activity,
negative regulation of transcription,
cell aging,
negative regulation of cell cycle |
| CD40 ligand |
CD_antigen |
cytokine activity,
tumor necrosis factor receptor binding,
CD40 receptor binding |
plasma membrane,
integral to membrane,
extracellular space |
inflammatory response,
platelet activation,
immunoglobulin secretion,
B cell differentiation,
isotype switching,
anti-apoptosis,
signal transduction,
B cell proliferation,
regulation of immunoglobulin secretion |
