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NameDescriptionMolecular FunctionCellular ComponentBiological Process
CD42C platelet glycoprotein IB beta chain precursor (GP-IB beta) (from PhosphoBase) transmembrane receptor activity,
protein binding
integral to membrane,
integral to plasma membrane,
platelet alpha granule membrane
platelet activation,
blood coagulation,
cell surface receptor linked signaling pathway,
cell adhesion
CD45 Receptor tyrosine phosphatase protein tyrosine phosphatase activity,
heparan sulfate proteoglycan binding,
protein kinase binding,
heparin binding,
transmembrane receptor protein tyrosine phosphatase activity
external side of plasma membrane,
membrane raft,
focal adhesion,
integral to plasma membrane
positive regulation of MAPKKK cascade,
regulation of S phase,
immunoglobulin biosynthetic process,
positive thymic T cell selection,
defense response to virus,
protein amino acid dephosphorylation,
positive regulation of antigen receptor-mediated signaling pathway,
positive regulation of apoptosis,
release of sequestered calcium ion into cytosol,
activation of MAPK activity,
negative regulation of T cell mediated cytotoxicity,
positive regulation of humoral immune response mediated by circulating immunoglobulin,
T cell receptor signaling pathway,
regulation of B cell receptor signaling pathway,
T cell proliferation,
heterotypic cell-cell adhesion,
negative regulation of protein amino acid autophosphorylation,
B cell differentiation,
positive regulation of isotype switching to IgG isotypes,
positive regulation of T cell mediated cytotoxicity,
positive regulation of B cell proliferation,
B cell receptor signaling pathway,
regulation of cell cycle,
positive regulation of alpha-beta T cell proliferation,
negative regulation of peptidyl-tyrosine phosphorylation,
positive regulation of gamma-delta T cell differentiation,
negative regulation of protein kinase activity,
negative thymic T cell selection,
regulation of B cell differentiation,
B cell proliferation,
negative regulation of cytokine-mediated signaling pathway,
leukocyte cell-cell adhesion
CD44 CD antigen collagen binding,
hyaluronic acid binding,
receptor activity,
receptor signaling protein activity
external side of plasma membrane,
basolateral plasma membrane,
integral to plasma membrane
branching involved in ureteric bud morphogenesis,
positive regulation of peptidyl-tyrosine phosphorylation,
positive regulation of ERK1 and ERK2 cascade,
branching involved in prostate gland morphogenesis,
positive regulation of peptidyl-serine phosphorylation,
negative regulation of DNA damage response, signal transduction by p53 class mediator,
cell-matrix adhesion,
cell-cell adhesion,
negative regulation of apoptosis,
wound healing involved in inflammatory response,
cell adhesion,
positive regulation of gene expression
CD4 coreceptor activity, extracellular matrix structural constituent MHC class II protein binding,
transmembrane receptor activity,
coreceptor activity,
extracellular matrix structural constituent,
protein homodimerization activity,
protein kinase binding,
glycoprotein binding,
zinc ion binding
T cell receptor complex,
integral to membrane,
endoplasmic reticulum membrane,
early endosome
induction by virus of host cell-cell fusion,
positive regulation of protein kinase activity,
maintenance of protein location in cell,
positive regulation of interleukin-2 biosynthetic process,
protein amino acid palmitoleylation,
initiation of viral infection,
transmembrane receptor protein tyrosine kinase signaling pathway,
T cell selection,
immune response,
cell adhesion
CD40 enzyme binding, receptor activity enzyme binding,
receptor activity
extracellular region,
external side of plasma membrane,
integral to membrane,
integral to plasma membrane,
intracellular membrane-bounded organelle
inflammatory response,
positive regulation of interleukin-12 production,
platelet activation,
positive regulation of isotype switching to IgG isotypes,
positive regulation of B cell proliferation,
protein complex assembly,
positive regulation of I-kappaB kinase/NF-kappaB cascade,
immune response-regulating cell surface receptor signaling pathway,
B cell activation,
B cell proliferation,
regulation of immunoglobulin secretion
PDCD4 Programmed cell death 4 RNA binding,
protein binding
cytosol,
nucleus
apoptosis,
negative regulation of JUN kinase activity,
negative regulation of transcription,
cell aging,
negative regulation of cell cycle
CD40 ligand CD_antigen cytokine activity,
tumor necrosis factor receptor binding,
CD40 receptor binding
plasma membrane,
integral to membrane,
extracellular space
inflammatory response,
platelet activation,
immunoglobulin secretion,
B cell differentiation,
isotype switching,
anti-apoptosis,
signal transduction,
B cell proliferation,
regulation of immunoglobulin secretion

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