Name | Description | Molecular Function | Cellular Component | Biological Process |
Spectrin |
Cytoskeletal protein |
spectrin binding, structural constituent of cytoskeleton, actin binding, calmodulin binding, protein N-terminus binding, syntaxin binding, protein complex binding, calcium ion binding, protein heterodimerization activity |
plasma membrane, microtubule cytoskeleton, cytosol, fascia adherens, protein complex, spectrin, membrane fraction, lateral plasma membrane, cuticular plate, Z disc |
actin filament capping, actin cytoskeleton reorganization |
Spectrin beta chain, brain 1 |
Cytoskeletal protein |
structural constituent of cytoskeleton, actin binding, calmodulin binding |
plasma membrane, M band, cytosol, spectrin, nucleolus, cuticular plate |
SMAD protein nuclear translocation, actin filament capping, common-partner SMAD protein phosphorylation |
Beta4-spectrin |
structural constituent of cytoskeleton |
structural constituent of cytoskeleton, actin binding, ankyrin binding |
cytosol, spectrin, PML body, nuclear matrix |
vesicle-mediated transport, actin filament capping, cytoskeletal anchoring at plasma membrane |
Spectrin beta 3 |
actin binding protein |
structural constituent of cytoskeleton, actin binding |
neuronal cell body, cytosol, spectrin |
actin filament capping, cell death |
Spectrin-like protein of the nuclear envelope and Golgi |
actin binding |
actin binding |
integral to membrane |
|
Spectrin alpha chain |
|
actin binding, calmodulin binding, calcium ion binding, microtubule binding |
plasma membrane, fusome, cytoskeleton, Golgi apparatus, neuromuscular junction, spectrosome, cell cortex |
ovarian follicle cell development, actin filament capping, fusome organization, germarium-derived oocyte fate determination, germarium-derived female germ-line cyst formation, maintenance of presynaptic active zone structure, neuromuscular synaptic transmission, central nervous system development, long-term strengthening of neuromuscular junction, spectrosome organization, oocyte construction, regulation of cell shape, negative regulation of microtubule depolymerization, plasma membrane organization, axon midline choice point recognition |
Spectrin beta chain |
|
structural constituent of cytoskeleton, actin binding, calmodulin binding, phosphatidylinositol-4,5-bisphosphate binding, microtubule binding |
fusome, spectrin, apicolateral plasma membrane, neuromuscular junction, spectrosome, lateral plasma membrane, axon |
actin filament capping, fusome organization, maintenance of presynaptic active zone structure, neuromuscular synaptic transmission, long-term strengthening of neuromuscular junction, spectrosome organization, negative regulation of microtubule depolymerization, plasma membrane organization, axon midline choice point recognition |