| Statistics: | ||
| Instances | 42.914 | |
| Kinases | 299 | |
| References | 3.657 | |
| Sequences | 11.224 | |
| Substrates | 8.698 |
| Name | Description | Molecular Function | Cellular Component | Biological Process |
|---|---|---|---|---|
| DUSP6 | protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity | protein tyrosine phosphatase activity, MAP kinase tyrosine/serine/threonine phosphatase activity |
cytoplasm, nucleoplasm |
inactivation of MAPK activity, peptidyl-tyrosine dephosphorylation, positive regulation of apoptosis, response to nitrosative stress, negative regulation of ERK1 and ERK2 cascade |
| USP6 | ubiquitin-specific protease activity, Rab GTPase activator activity, nucleic acid binding, calmodulin binding, ubiquitin thiolesterase activity, cysteine-type endopeptidase activity |
plasma membrane, recycling endosome, lysosome |
ubiquitin-dependent protein catabolic process, regulation of vesicle-mediated transport, protein deubiquitination, regulation of Rab GTPase activity |