| Name | Description | Molecular Function | Cellular Component | Biological Process |
|---|
| Bsg |
Basigin |
lactate transmembrane transporter activity,
mannose binding,
protein binding |
melanosome,
integral to membrane,
Golgi membrane,
membrane |
cell surface receptor linked signaling pathway |
| Src substrate cortactin |
Involved in the organization of cell structure |
protein binding |
plasma membrane,
cytoskeleton,
soluble fraction,
ruffle,
endoplasmic reticulum,
lamellipodium,
cell cortex |
|
| Insulin receptor substrate 2 |
Adaptor molecule |
signal transducer activity,
receptor activity,
protein kinase binding |
plasma membrane,
cytosol |
positive regulation of mesenchymal cell proliferation,
positive regulation of cell migration,
positive regulation of fatty acid beta-oxidation,
mammary gland development,
glucose metabolic process,
cell proliferation,
brain development,
negative regulation of kinase activity,
positive regulation of insulin secretion,
positive regulation of B cell proliferation,
response to glucose stimulus,
lipid homeostasis,
positive regulation of glycogen biosynthetic process,
negative regulation of plasma membrane long-chain fatty acid transport,
negative regulation of B cell apoptosis,
insulin receptor signaling pathway,
positive regulation of glucose import |
| Insulin receptor substrate 1 |
After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains. |
protein kinase C binding,
insulin-like growth factor receptor binding,
insulin receptor binding,
transmembrane receptor protein tyrosine kinase docking protein activity,
phosphoinositide 3-kinase binding,
insulin-like growth factor receptor activity,
SH2 domain binding |
microsome,
cytosol,
caveola,
insulin receptor complex,
nucleus |
positive regulation of mesenchymal cell proliferation,
negative regulation of somatostatin secretion,
positive regulation of insulin receptor signaling pathway,
positive regulation of cell migration,
positive regulation of fatty acid beta-oxidation,
negative regulation of insulin secretion,
mammary gland development,
protein heterooligomerization,
positive regulation of phosphoinositide 3-kinase activity,
negative regulation of insulin receptor signaling pathway,
glucose homeostasis,
phosphoinositide 3-kinase cascade,
protein kinase B signaling cascade,
positive regulation of glycogen biosynthetic process,
insulin receptor signaling pathway,
positive regulation of glucose import,
positive regulation of phosphorylation,
positive regulation of glucagon secretion |
| Insulin receptor substrate 4 |
Cell cycle control protein |
insulin receptor binding,
SH3/SH2 adaptor activity |
plasma membrane |
|
| FGFR substrate 3 |
Adapter molecule |
insulin receptor binding |
membrane |
|
| Epidermal growth factor receptor kinase substrate 8 |
Upon binding to EGF receptor enhances EGF-dependent mitogenic signals |
SH3/SH2 adaptor activity,
protein binding |
N-methyl-D-aspartate selective glutamate receptor complex,
synaptosome,
postsynaptic density |
behavioral response to ethanol,
epidermal growth factor receptor signaling pathway,
adult locomotory behavior,
cell proliferation,
actin cytoskeleton reorganization |
| Sorbs1 |
Unclassified |
insulin receptor binding,
SH3/SH2 adaptor activity,
actin binding,
protein kinase binding |
stress fiber,
cytosol,
membrane raft,
zonula adherens,
cell-cell adherens junction,
focal adhesion,
nucleus |
stress fiber assembly,
focal adhesion assembly,
muscle contraction,
positive regulation of glycogen biosynthetic process,
positive regulation of lipid biosynthetic process,
glucose transport,
positive regulation of establishment of protein localization in plasma membrane,
insulin receptor signaling pathway,
positive regulation of glucose import |
| Insulin receptor tyrosine kinase substrate |
unclassified |
cytoskeletal adaptor activity,
actin binding,
SH3 domain binding |
|
signal transduction,
filopodium assembly |
| Protein kinase C and casein kinase substrate in neurons protein 3 |
cytoskeletal protein binding |
cytoskeletal protein binding |
plasma membrane,
cytoplasm |
positive regulation of membrane protein ectodomain proteolysis,
negative regulation of endocytosis,
endocytosis |
| FGFR substrate 2 |
Adapter molecule |
insulin receptor binding,
transmembrane receptor protein tyrosine kinase docking protein activity |
plasma membrane,
cytoplasm |
anterior/posterior axis specification, embryo,
ventricular septum development,
regulation of epithelial cell proliferation,
optic placode formation involved in camera-type eye,
activation of MAPK activity,
neuroblast proliferation,
forebrain development,
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis,
gastrulation with mouth forming second,
induction of an organ,
fibroblast growth factor receptor signaling pathway |
| ATP-dependent RNA helicase abstrakt |
|
ATP-dependent helicase activity,
RNA binding,
ATP binding,
zinc ion binding,
protein binding |
catalytic step 2 spliceosome,
precatalytic spliceosome |
nuclear mRNA splicing, via spliceosome |
| bs |
|
sequence-specific DNA binding,
sequence-specific DNA binding transcription factor activity |
nucleus |
pupal development,
instar larval development,
regulation of transcription, DNA-dependent,
sleep,
apposition of dorsal and ventral imaginal disc-derived wing surfaces,
terminal branching, open tracheal system,
transcription,
terminal cell fate specification, open tracheal system |
| Bsg25D |
|
protein binding |
|
multicellular organismal development |
| Homeotic protein Sex combs reduced |
|
sequence-specific DNA binding,
sequence-specific DNA binding transcription factor activity |
nucleus |
specification of segmental identity, labial segment,
regulation of transcription, DNA-dependent,
salivary gland boundary specification,
sex comb development,
midgut development,
sex differentiation |
| OBSL1 |
|
cytoskeletal adaptor activity |
intercalated disc,
M band,
perinuclear region of cytoplasm,
Z disc |
cardiac myofibril assembly |
| WBSCR20C |
|
methyltransferase activity |
|
|
| HBS1 |
|
GTP binding,
GTPase activity,
translation elongation factor activity |
|
signal transduction |
