| Name | Description | Molecular Function | Cellular Component | Biological Process |
|---|
| p21 |
Cyclin-dependent kinase inhibitor 1 (p21) |
cyclin-dependent protein kinase inhibitor activity,
metal ion binding |
cytosol,
cyclin-dependent protein kinase holoenzyme complex,
PCNA-p21 complex,
nucleoplasm |
cellular response to extracellular stimulus,
senescence,
negative regulation of cell proliferation,
cell cycle arrest,
positive regulation of fibroblast proliferation,
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest,
negative regulation of cell growth,
G1/S transition of mitotic cell cycle,
induction of apoptosis by intracellular signals,
Ras protein signal transduction,
G2/M transition of mitotic cell cycle |
| p21-Rac1 |
GTPase |
thioesterase binding,
GTP binding,
GTPase activity,
GTP-dependent protein binding |
plasma membrane,
cytosol,
melanosome |
localization within membrane,
induction of apoptosis by extracellular signals,
negative regulation of receptor-mediated endocytosis,
apoptosis,
actin filament polymerization,
anatomical structure morphogenesis,
inflammatory response,
regulation of hydrogen peroxide metabolic process,
cell-matrix adhesion,
regulation of respiratory burst,
lamellipodium assembly,
positive regulation of lamellipodium assembly,
cellular component movement,
positive regulation of Rho protein signal transduction,
small GTPase mediated signal transduction,
ruffle organization |
| Pp21 protein |
Transcription regulatory protein |
RNA polymerase II transcription factor activity,
sequence-specific DNA binding transcription factor activity |
nucleus |
transcription,
negative regulation of transcription from RNA polymerase II promoter |
| Nucleoporin Nup214 |
Transport/cargo protein |
transporter activity,
protein binding |
cytosol,
nuclear pore |
transmembrane transport,
mRNA transport,
protein export from nucleus |
| Arhgap21 |
Unclassified |
GTPase activator activity,
protein binding |
cell junction,
cytoskeleton,
cytoplasmic vesicle membrane,
Golgi membrane |
signal transduction |
