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NameDescriptionMolecular FunctionCellular ComponentBiological Process
p21 Cyclin-dependent kinase inhibitor 1 (p21) cyclin-dependent protein kinase inhibitor activity,
metal ion binding
cyclin-dependent protein kinase holoenzyme complex,
PCNA-p21 complex,
cellular response to extracellular stimulus,
negative regulation of cell proliferation,
cell cycle arrest,
positive regulation of fibroblast proliferation,
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest,
negative regulation of cell growth,
G1/S transition of mitotic cell cycle,
induction of apoptosis by intracellular signals,
Ras protein signal transduction,
G2/M transition of mitotic cell cycle
p21-Rac1 GTPase thioesterase binding,
GTP binding,
GTPase activity,
GTP-dependent protein binding
plasma membrane,
localization within membrane,
induction of apoptosis by extracellular signals,
negative regulation of receptor-mediated endocytosis,
actin filament polymerization,
anatomical structure morphogenesis,
inflammatory response,
regulation of hydrogen peroxide metabolic process,
cell-matrix adhesion,
regulation of respiratory burst,
lamellipodium assembly,
positive regulation of lamellipodium assembly,
cellular component movement,
positive regulation of Rho protein signal transduction,
small GTPase mediated signal transduction,
ruffle organization
Pp21 protein Transcription regulatory protein RNA polymerase II transcription factor activity,
sequence-specific DNA binding transcription factor activity
nucleus transcription,
negative regulation of transcription from RNA polymerase II promoter
Nucleoporin Nup214 Transport/cargo protein transporter activity,
protein binding
nuclear pore
transmembrane transport,
mRNA transport,
protein export from nucleus
Arhgap21 Unclassified GTPase activator activity,
protein binding
cell junction,
cytoplasmic vesicle membrane,
Golgi membrane
signal transduction

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