| Name | Description | Molecular Function | Cellular Component | Biological Process |
|---|
| p53 |
Cellular tumor antigen p53 |
RNA polymerase II transcription factor activity,
DNA strand annealing activity,
chromatin binding,
promoter binding,
histone deacetylase regulator activity,
transcription repressor activity,
protein heterodimerization activity,
protein C-terminus binding,
protein phosphatase 2A binding,
protein kinase binding,
ubiquitin protein ligase binding,
transcription activator activity,
protease binding,
transcription factor binding,
zinc ion binding,
chaperone binding,
sequence-specific DNA binding transcription factor activity,
copper ion binding,
ATP binding,
histone acetyltransferase binding,
protein N-terminus binding,
sequence-specific DNA binding |
protein complex,
PML body,
replication fork,
mitochondrion,
chromatin,
nucleolus,
nuclear matrix,
cytosol,
transcription factor complex,
soluble fraction,
insoluble fraction,
endoplasmic reticulum |
response to salt stress,
response to vitamin B3,
response to X-ray,
ER overload response,
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis,
wound healing,
negative regulation of neuroblast proliferation,
B cell lineage commitment,
response to UV,
central nervous system development,
negative regulation of apoptosis,
negative regulation of DNA replication,
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest,
negative regulation of helicase activity,
negative regulation of cell growth,
negative regulation of transforming growth factor beta receptor signaling pathway,
positive regulation of cell cycle,
base-excision repair,
activation of caspase activity by cytochrome c,
cell aging,
release of cytochrome c from mitochondria,
gastrulation,
cell cycle,
in utero embryonic development,
positive regulation of histone deacetylation,
regulation of mitochondrial membrane permeability,
response to gamma radiation,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
negative regulation of smooth muscle cell proliferation,
response to tumor cell,
regulation of intracellular pH,
multicellular organism growth,
transforming growth factor beta receptor signaling pathway,
response to caffeine,
Ras protein signal transduction,
nucleotide-excision repair,
response to retinoic acid,
T cell differentiation in the thymus,
negative regulation of transcription from RNA polymerase II promoter,
multicellular organismal development,
response to hyperoxia,
positive regulation of leukocyte migration,
somitogenesis,
chromosome organization,
positive regulation of gene-specific transcription from RNA polymerase II promoter,
negative regulation of fibroblast proliferation,
senescence,
positive regulation of neuron apoptosis,
response to amino acid stimulus,
response to oxidative stress,
mitotic cell cycle G1/S DNA damage checkpoint,
cell cycle arrest,
response to drug,
positive regulation of apoptosis,
rRNA transcription,
response to cytokine stimulus,
interspecies interaction between organisms,
double-strand break repair,
T cell lineage commitment,
protein tetramerization,
protein import into nucleus, translocation,
response to metal ion,
cellular response to UV,
T cell proliferation involved in immune response,
transcription,
cellular response to glucose starvation |
| p56(dok-2) |
Adapter molecule |
identical protein binding,
insulin receptor binding,
transmembrane receptor protein tyrosine kinase docking protein activity |
|
MAPKKK cascade,
transmembrane receptor protein tyrosine kinase signaling pathway,
Ras protein signal transduction |
| p53-binding protein 1 |
Transcription regulatory protein |
transcription activator activity,
protein binding |
condensed chromosome kinetochore,
cytoplasm,
nucleoplasm |
positive regulation of transcription, DNA-dependent,
transcription,
DNA repair |
| p50 dynamitin |
modulates dynein function |
motor activity,
protein binding |
dynactin complex,
cytosol,
dynein complex,
kinetochore,
growth cone,
microtubule,
centrosome,
membrane |
mitosis,
cell proliferation |
| P532 |
ARF guanyl-nucleotide exchange factor activity |
acid-amino acid ligase activity,
ARF guanyl-nucleotide exchange factor activity |
cytosol,
Golgi apparatus,
membrane |
protein modification process,
transport |
