Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)

Seq-ID:

P35568 [Homo sapiens]

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Interaction Network(s):

External Source(s):

MINT Interaction(s):

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GO-Terms:

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Molecular Function	Cellular Component	Biological Process
phosphoinositide 3-kinase binding, protein kinase C binding, insulin-like growth factor receptor binding, insulin receptor binding, transmembrane receptor protein tyrosine kinase docking protein activity, SH2 domain binding	microsome, caveola, cytosol, insulin receptor complex, nucleus	negative regulation of insulin receptor signaling pathway, glucose homeostasis, positive regulation of insulin receptor signaling pathway, positive regulation of fatty acid beta-oxidation, phosphoinositide 3-kinase cascade, negative regulation of insulin secretion, positive regulation of glycogen biosynthetic process, insulin receptor signaling pathway, positive regulation of glucose import, positive regulation of phosphoinositide 3-kinase activity

Conservation:

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Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	46	SEAGGPARLEYYENEKKWRHK	-	15592455	HTP	1.00		-	PH	0.49	1QQG	9.61%
Y	46	SEAGGPARLEYYENEKKWRHK	-	18083107	HTP	1.00		-	PH	0.49	1QQG	9.61%