Substrate: Beta-catenin (Adhesion molecule)
Seq-ID: P35222 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-46005   CADH1_HUMAN
MINT-46006   CTNA1_HUMAN
MINT-49803   ANDR_HUMAN
MINT-49805   NCOA2_HUMAN
MINT-1779698   TF7L2_HUMAN
MINT-1792780   LAP2_HUMAN
MINT-1792796   PKP4_HUMAN
MINT-2839028   LAP2B_HUMAN
MINT-2839079   EMD_HUMAN
MINT-4085223   CADH5_HUMAN
MINT-4085261   PARD3_HUMAN
MINT-4085491   CADH2_HUMAN
MINT-4508051   GSK3B_HUMAN
MINT-4508065   ITF2_HUMAN
MINT-4508192   AXN1_HUMAN
MINT-4508216   ABL1_HUMAN
MINT-4508229   APC_HUMAN
MINT-6823807   HDAC1_HUMAN
MINT-7023862   NFKB1_HUMAN
MINT-7952417   TNIK_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
R-SMAD binding,
cadherin binding,
androgen receptor binding,
alpha-catenin binding,
kinase binding,
protein phosphatase binding,
transcription coactivator activity,
promoter binding,
signal transducer activity,
estrogen receptor binding,
I-SMAD binding,
protein C-terminus binding		 Axin-APC-beta-catenin-GSK3B complex,
catenin complex,
transcription factor complex,
perinuclear region of cytoplasm,
cell cortex,
protein-DNA complex,
beta-catenin-TCF7L2 complex,
centrosome,
cell-substrate adherens junction,
lateral plasma membrane		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
patterning of blood vessels,
protein localization at cell surface,
positive regulation of heparan sulfate proteoglycan biosynthetic process,
negative regulation of cell proliferation,
cellular response to indole-3-methanol,
response to drug,
positive regulation of anti-apoptosis,
positive regulation of apoptosis,
canonical Wnt receptor signaling pathway,
regulation of calcium ion import,
androgen receptor signaling pathway,
adherens junction assembly,
regulation of fibroblast proliferation,
epithelial to mesenchymal transition,
regulation of smooth muscle cell proliferation,
cell-cell adhesion,
cellular response to growth factor stimulus,
positive regulation of epithelial to mesenchymal transition,
regulation of angiogenesis,
endothelial tube morphogenesis,
negative regulation of apoptosis,
transcription,
regulation of centriole-centriole cohesion,
regulation of centromeric sister chromatid cohesion,
response to estradiol stimulus
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 41 LDSGIHSGATTTAPSLSGKGN GSK-3_group 12051714
LTP
0.90
 MOD_GSK3_1
 - -
0.75
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