Substrate: Axin1 (Adapter molecule)
Seq-ID: O15169 [Homo sapiens]
Download:fasta csv
Interaction Network(s):
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-64311   AN32A_HUMAN
MINT-64317   UT14A_HUMAN
MINT-4508192   CTNB1_HUMAN
MINT-4508259   GSK3B_HUMAN
MINT-4544575   PP1A_HUMAN
MINT-4544606   GSK3A_HUMAN
MINT-7040788   MYC_HUMAN
MINT-7229769   NIN_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein complex scaffold,
I-SMAD binding,
protein homodimerization activity,
ubiquitin protein ligase binding,
armadillo repeat domain binding,
beta-catenin binding,
signal transducer activity		 Axin-APC-beta-catenin-GSK3B complex,
beta-catenin destruction complex,
cytosol,
lateral plasma membrane,
nucleus		 oocyte axis specification,
positive regulation of protein catabolic process,
positive regulation of transcription,
apoptosis,
positive regulation of peptidyl-serine phosphorylation,
activation of protein kinase activity,
negative regulation of Wnt receptor signaling pathway,
canonical Wnt receptor signaling pathway,
positive regulation of peptidyl-threonine phosphorylation,
positive regulation of ubiquitin-protein ligase activity,
positive regulation of JNK cascade,
cellular protein complex assembly
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 77 DLGYEPEGSASPTPPYLKWAE - 18669648
HTP
1.00
 - -
0.46
 1DK8 88.52%
T 213 KSDIYLEYTRTGSESPKVCSD - 18669648
HTP
1.00
 - -
0.37
 1DK8 57.53%
S 217 YLEYTRTGSESPKVCSDQSSG - 18669648
HTP
1.00
 - -
0.53
 1DK8 84.43%

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