Substrate: Axin1 (Adapter molecule)
Seq-ID: O15169 [Homo sapiens]
Download:fasta csv
Interaction Network(s):
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-64311   AN32A_HUMAN
MINT-64317   UT14A_HUMAN
MINT-4508192   CTNB1_HUMAN
MINT-4508259   GSK3B_HUMAN
MINT-4544575   PP1A_HUMAN
MINT-4544606   GSK3A_HUMAN
MINT-7040788   MYC_HUMAN
MINT-7229769   NIN_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein complex scaffold,
I-SMAD binding,
protein homodimerization activity,
ubiquitin protein ligase binding,
armadillo repeat domain binding,
beta-catenin binding,
signal transducer activity		 Axin-APC-beta-catenin-GSK3B complex,
beta-catenin destruction complex,
cytosol,
lateral plasma membrane,
nucleus		 oocyte axis specification,
positive regulation of protein catabolic process,
positive regulation of transcription,
apoptosis,
positive regulation of peptidyl-serine phosphorylation,
activation of protein kinase activity,
negative regulation of Wnt receptor signaling pathway,
canonical Wnt receptor signaling pathway,
positive regulation of peptidyl-threonine phosphorylation,
positive regulation of ubiquitin-protein ligase activity,
positive regulation of JNK cascade,
cellular protein complex assembly
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 77 DLGYEPEGSASPTPPYLKWAE - 18669648
HTP
1.00
 - -
0.46
 1DK8 88.52%
T 213 KSDIYLEYTRTGSESPKVCSD - 18669648
HTP
1.00
 - -
0.37
 1DK8 57.53%
S 217 YLEYTRTGSESPKVCSDQSSG - 18669648
HTP
1.00
 - -
0.53
 1DK8 84.43%

Substrate: Axin1 (Adapter molecule)
Seq-ID: O35625 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein complex scaffold,
I-SMAD binding,
protein C-terminus binding,
protein homodimerization activity,
specific transcriptional repressor activity,
protein kinase binding,
ubiquitin protein ligase binding,
beta-catenin binding,
signal transducer activity		 Axin-APC-beta-catenin-GSK3B complex,
cytoplasmic membrane-bounded vesicle,
glycoprotein network,
soluble fraction,
nucleus,
cell cortex		 negative regulation of gene-specific transcription elongation from RNA polymerase II promoter,
positive regulation of transcription,
dorsal/ventral axis specification,
negative regulation of fat cell differentiation,
tail morphogenesis,
apoptosis,
positive regulation of JUN kinase activity,
sensory perception of sound,
axial mesoderm formation,
genetic imprinting,
negative regulation of Wnt receptor signaling pathway,
canonical Wnt receptor signaling pathway,
negative regulation of protein metabolic process,
protein catabolic process,
positive regulation of ubiquitin-protein ligase activity,
positive regulation of JNK cascade,
protein homooligomerization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 480 LDEHVQRVMRTPGCQSPGPGH GSK-3_beta 10581160
LTP
1.00
 - Axin_b-cat_bind
0.84
 - medium
S 485 QRVMRTPGCQSPGPGHRSPDS GSK-3_beta 10581160
LTP
1.00
 - Axin_b-cat_bind
0.91
 - medium
S 492 GCQSPGPGHRSPDSGHVAKTA - 10581160
LTP
1.00
 - Axin_b-cat_bind
0.90
 - medium

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