Substrate: Axin1 (Adapter molecule)
Seq-ID: O35625 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein complex scaffold,
I-SMAD binding,
protein C-terminus binding,
protein homodimerization activity,
specific transcriptional repressor activity,
protein kinase binding,
ubiquitin protein ligase binding,
beta-catenin binding,
signal transducer activity		 Axin-APC-beta-catenin-GSK3B complex,
cytoplasmic membrane-bounded vesicle,
glycoprotein network,
soluble fraction,
nucleus,
cell cortex		 negative regulation of gene-specific transcription elongation from RNA polymerase II promoter,
positive regulation of transcription,
dorsal/ventral axis specification,
negative regulation of fat cell differentiation,
tail morphogenesis,
apoptosis,
positive regulation of JUN kinase activity,
sensory perception of sound,
axial mesoderm formation,
genetic imprinting,
negative regulation of Wnt receptor signaling pathway,
canonical Wnt receptor signaling pathway,
negative regulation of protein metabolic process,
protein catabolic process,
positive regulation of ubiquitin-protein ligase activity,
positive regulation of JNK cascade,
protein homooligomerization
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 480 LDEHVQRVMRTPGCQSPGPGH GSK-3_beta 10581160
LTP
1.00
 - Axin_b-cat_bind
0.84
 - medium
S 485 QRVMRTPGCQSPGPGHRSPDS GSK-3_beta 10581160
LTP
1.00
 - Axin_b-cat_bind
0.91
 - medium
S 492 GCQSPGPGHRSPDSGHVAKTA - 10581160
LTP
1.00
 - Axin_b-cat_bind
0.90
 - medium

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