Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: P00533 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16802   GRB10_HUMAN
MINT-50935   1433Z_HUMAN
MINT-51101   ANXA1_HUMAN
MINT-51490   ARBK1_HUMAN
MINT-60973   CBL_HUMAN
MINT-61486   CRKL_HUMAN
MINT-61487   CSK_HUMAN
MINT-61490   STA5B_HUMAN
MINT-61540   GRB2_HUMAN
MINT-68514   PDC6I_HUMAN
MINT-74427   ABL1_HUMAN
MINT-74438   ABL2_HUMAN
MINT-74460   ANS1A_HUMAN
MINT-74469   APBB1_HUMAN
MINT-74479   DP13A_HUMAN
MINT-74487   BMX_HUMAN
MINT-74497   CRK_HUMAN
MINT-74535   FES_HUMAN
MINT-74551   IRS1_HUMAN
MINT-74555   IRS4_HUMAN
MINT-74562   JAK2_HUMAN
MINT-74566   SH2B3_HUMAN
MINT-74572   JIP1_HUMAN
MINT-74587   NCK1_HUMAN
MINT-74593   NUMB_HUMAN
MINT-74594   NUMBL_HUMAN
MINT-74606   P85A_HUMAN
MINT-74630   P85B_HUMAN
MINT-74659   P55G_HUMAN
MINT-74678   PLCG1_HUMAN
MINT-74685   PLCG2_HUMAN
MINT-74687   PTK6_HUMAN
MINT-74689   PTN11_HUMAN
MINT-74711   RASA1_HUMAN
MINT-74717   SH2B1_HUMAN
MINT-74720   SH22A_HUMAN
MINT-74732   SHC1_HUMAN
MINT-74746   SLAP1_HUMAN
MINT-74763   KSYK_HUMAN
MINT-74790   TLN1_HUMAN
MINT-74807   ZAP70_HUMAN
MINT-1788719   ERBB2_HUMAN
MINT-6169667   ESR1_HUMAN
MINT-6170031   SOS1_MOUSE
MINT-6170198   SH3G2_HUMAN
MINT-6170268   SH3K1_HUMAN
MINT-6793358   PTN1_HUMAN
MINT-7980526   TM1L1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor activity,
protein heterodimerization activity,
identical protein binding,
receptor signaling protein tyrosine kinase activity,
double-stranded DNA binding,
ATP binding,
protein phosphatase binding,
actin filament binding,
MAP/ERK kinase kinase activity		 Shc-EGFR complex,
endosome,
basolateral plasma membrane,
integral to membrane,
extracellular space,
nucleus		 activation of phospholipase C activity,
protein insertion into membrane,
response to UV-A,
positive regulation of nitric oxide biosynthetic process,
positive regulation of cell migration,
positive regulation of cyclin-dependent protein kinase activity involved in G1/S,
positive regulation of catenin protein nuclear translocation,
regulation of nitric-oxide synthase activity,
positive regulation of protein kinase B signaling cascade,
ossification,
positive regulation of epithelial cell proliferation,
activation of phospholipase A2 activity by calcium-mediated signaling,
cell-cell adhesion,
regulation of peptidyl-tyrosine phosphorylation,
positive regulation of phosphorylation,
positive regulation of MAP kinase activity,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 678 MRRRHIVRKRTLRRLLQEREL - 15302935
HTP
1.00
 - -
0.28
 --
T 678 MRRRHIVRKRTLRRLLQEREL PKC_group 6090944
LTP
1.00
 - -
0.28
 --
T 678 MRRRHIVRKRTLRRLLQEREL PKC_alpha 6090944
LTP
1.00
 - -
0.28
 --
T 678 MRRRHIVRKRTLRRLLQEREL PKC_group 1860884
LTP
1.00
 - -
0.28
 --
T 678 MRRRHIVRKRTLRRLLQEREL PKC_alpha 1860884
LTP
1.00
 - -
0.28
 --
T 678 MRRRHIVRKRTLRRLLQEREL - 3379075
LTP
1.00
 - -
0.28
 --
T 693 LQERELVEPLTPSGEAPNQAL - 15302935
HTP
1.00
 MOD_ProDKin_1
 - -
0.41
 --
T 693 LQERELVEPLTPSGEAPNQAL MAPK1 1939237
LTP
1.00
 MOD_ProDKin_1
 - -
0.41
 --
T 693 LQERELVEPLTPSGEAPNQAL MAPK3 1939237
LTP
1.00
 MOD_ProDKin_1
 - -
0.41
 --
T 693 LQERELVEPLTPSGEAPNQAL - 1651323
LTP
1.00
 MOD_ProDKin_1
 - -
0.41
 --
T 693 LQERELVEPLTPSGEAPNQAL - 3138233
LTP
1.00
 MOD_ProDKin_1
 - -
0.41
 --
T 693 LQERELVEPLTPSGEAPNQAL - 2115882
LTP
1.00
 MOD_ProDKin_1
 - -
0.41
 --
T 693 LQERELVEPLTPSGEAPNQAL - 2543683
LTP
1.00
 MOD_ProDKin_1
 - -
0.41
 --
T 693 LQERELVEPLTPSGEAPNQAL - 17081983
HTP
1.00
 MOD_ProDKin_1
 - -
0.41
 --
T 693 LQERELVEPLTPSGEAPNQAL - 17192257
HTP
1.00
 MOD_ProDKin_1
 - -
0.41
 --
T 693 LQERELVEPLTPSGEAPNQAL - 18220336
HTP
1.00
 MOD_ProDKin_1
 - -
0.41
 --
T 693 LQERELVEPLTPSGEAPNQAL - 18669648
HTP
1.00
 MOD_ProDKin_1
 - -
0.41
 --
S 695 ERELVEPLTPSGEAPNQALLR - 1956339
LTP
1.00
 - -
0.35
 --
S 695 ERELVEPLTPSGEAPNQALLR - 15302935
HTP
1.00
 - -
0.35
 --
S 695 ERELVEPLTPSGEAPNQALLR - 18669648
HTP
1.00
 - -
0.35
 --
S 768 EILDEAYVMASVDNPHVCRLL - 15302935
HTP
1.00
 - TyrKc
0.10
 3BEL 38.52%
S 768 EILDEAYVMASVDNPHVCRLL CaM-KII_alpha 10347170
LTP
1.00
 - TyrKc
0.10
 3BEL 38.52%
Y 869 AKLLGAEEKEYHAEGGKVPIK - 11983694
LTP
1.00
 - TyrKc
0.18
 2EB2 17.03%
Y 869 AKLLGAEEKEYHAEGGKVPIK SRC 10075741
LTP
1.00
 - TyrKc
0.18
 2EB2 17.03%
Y 869 AKLLGAEEKEYHAEGGKVPIK - 18083107
HTP
1.00
 - TyrKc
0.18
 2EB2 17.03%
Y 915 WELMTFGSKPYDGIPASEISS SRC 11983694
LTP
1.00
 PLCG1 SH2;
Src SH2		 TyrKc
0.18
 3BEL 8.30%
Y 944 PQPPICTIDVYMIMVKCWMID SRC 11983694
LTP
1.00
 PIK3R1 SH2;
Src SH2		 TyrKc
0.05
 3BEL 16.16%
Y 978 FSKMARDPQRYLVIQGDERMH - 16097034
HTP
1.00
 PTPN11 SH2 -
0.35
 3BEL 4.37%
S 991 IQGDERMHLPSPTDSNFYRAL - 15901825
LTP
1.00
 - -
0.41
 2J5F 55.74%
S 991 IQGDERMHLPSPTDSNFYRAL - 17081983
HTP
1.00
 - -
0.41
 2J5F 55.74%
S 991 IQGDERMHLPSPTDSNFYRAL - 18220336
HTP
1.00
 - -
0.41
 2J5F 55.74%
S 991 IQGDERMHLPSPTDSNFYRAL - 18669648
HTP
1.00
 - -
0.41
 2J5F 55.74%
T 993 GDERMHLPSPTDSNFYRALMD - 18669648
HTP
0.19
 - -
0.45
 --
S 995 ERMHLPSPTDSNFYRALMDEE - 18669648
HTP
1.00
 - -
0.49
 1XKK 86.07%
Y 998 HLPSPTDSNFYRALMDEEDMD - 15951569
HTP
0.31
 PLCG1 SH2 -
0.49
 3BEL 13.10%
Y 998 HLPSPTDSNFYRALMDEEDMD - 17081983
HTP
0.31
 PLCG1 SH2 -
0.49
 3BEL 13.10%
Y 998 HLPSPTDSNFYRALMDEEDMD - 18669648
HTP
0.31
 PLCG1 SH2 -
0.49
 3BEL 13.10%
Y 1016 DMDDVVDADEYLIPQQGFFSS SRC 8845374
LTP
1.00
 CRK SH2;
PLCG1 SH2;
RASA_group SH2;
Src SH2		 -
0.41
 1XKK 41.92%
Y 1016 DMDDVVDADEYLIPQQGFFSS - 7680558
LTP
1.00
 CRK SH2;
PLCG1 SH2;
RASA_group SH2;
Src SH2		 -
0.41
 1XKK 41.92%
Y 1016 DMDDVVDADEYLIPQQGFFSS - 15302935
HTP
1.00
 CRK SH2;
PLCG1 SH2;
RASA_group SH2;
Src SH2		 -
0.41
 1XKK 41.92%
S 1025 EYLIPQQGFFSSPSTSRTPLL - 18669648
HTP
0.25
 - -
0.43
 --
S 1026 YLIPQQGFFSSPSTSRTPLLS - 15302935
HTP
0.23
 - -
0.42
 --
S 1026 YLIPQQGFFSSPSTSRTPLLS CDK1 8360196
LTP
0.23
 - -
0.42
 --
S 1026 YLIPQQGFFSSPSTSRTPLLS - 18669648
HTP
0.23
 - -
0.42
 --
S 1028 IPQQGFFSSPSTSRTPLLSSL - 15302935
HTP
0.96
 - -
0.43
 --
S 1028 IPQQGFFSSPSTSRTPLLSSL - 18669648
HTP
0.96
 - -
0.43
 --
S 1037 PSTSRTPLLSSLSATSNNSTV - 18669648
HTP
1.00
 - -
0.55
 --
S 1039 TSRTPLLSSLSATSNNSTVAC - 17081983
HTP
0.34
 - -
0.49
 --
S 1039 TSRTPLLSSLSATSNNSTVAC - 18669648
HTP
0.34
 - -
0.49
 --
T 1041 RTPLLSSLSATSNNSTVACID - 18669648
HTP
0.20
 - -
0.42
 --
S 1042 TPLLSSLSATSNNSTVACIDR - 17081983
HTP
0.99
 - -
0.42
 --
S 1042 TPLLSSLSATSNNSTVACIDR - 18669648
HTP
0.99
 - -
0.42
 --
S 1045 LSSLSATSNNSTVACIDRNGL - 17081983
HTP
0.14
 - -
0.44
 --
S 1045 LSSLSATSNNSTVACIDRNGL - 18669648
HTP
0.14
 - -
0.44
 --
S 1064 GLQSCPIKEDSFLQRYSSDPT - 17081983
HTP
0.98
 - -
0.52
 --
S 1064 GLQSCPIKEDSFLQRYSSDPT - 18669648
HTP
0.98
 - -
0.52
 --
Y 1069 PIKEDSFLQRYSSDPTGALTE - 15302935
HTP
1.00
 PLCG1 SH2;
RASA_group SH2		 -
0.57
 --
Y 1069 PIKEDSFLQRYSSDPTGALTE - 17081983
HTP
1.00
 PLCG1 SH2;
RASA_group SH2		 -
0.57
 --
Y 1069 PIKEDSFLQRYSSDPTGALTE - 18669648
HTP
1.00
 PLCG1 SH2;
RASA_group SH2		 -
0.57
 --
S 1070 IKEDSFLQRYSSDPTGALTED - 1956339
LTP
1.00
 - -
0.59
 --
S 1070 IKEDSFLQRYSSDPTGALTED - 15302935
HTP
1.00
 - -
0.59
 --
S 1070 IKEDSFLQRYSSDPTGALTED CaM-KII_alpha 10347170
LTP
1.00
 - -
0.59
 --
S 1070 IKEDSFLQRYSSDPTGALTED - 7805884
LTP
1.00
 - -
0.59
 --
S 1070 IKEDSFLQRYSSDPTGALTED - 1309762
LTP
1.00
 - -
0.59
 --
S 1070 IKEDSFLQRYSSDPTGALTED - 3138233
LTP
1.00
 - -
0.59
 --
S 1070 IKEDSFLQRYSSDPTGALTED - 7505275
LTP
1.00
 - -
0.59
 --
S 1071 KEDSFLQRYSSDPTGALTEDS - 1956339
LTP
0.09
 - -
0.61
 --
S 1071 KEDSFLQRYSSDPTGALTEDS - 15302935
HTP
0.09
 - -
0.61
 --
S 1071 KEDSFLQRYSSDPTGALTEDS CaM-KII_alpha 10347170
LTP
0.09
 - -
0.61
 --
S 1071 KEDSFLQRYSSDPTGALTEDS - 7805884
LTP
0.09
 - -
0.61
 --
S 1071 KEDSFLQRYSSDPTGALTEDS - 1309762
LTP
0.09
 - -
0.61
 --
S 1071 KEDSFLQRYSSDPTGALTEDS - 3138233
LTP
0.09
 - -
0.61
 --
S 1071 KEDSFLQRYSSDPTGALTEDS - 7505275
LTP
0.09
 - -
0.61
 --
T 1078 RYSSDPTGALTEDSIDDTFLP - 18669648
HTP
0.07
 - -
0.61
 --
S 1081 SDPTGALTEDSIDDTFLPVPE - 15302935
HTP
0.23
 - -
0.60
 --
S 1081 SDPTGALTEDSIDDTFLPVPE CaM-KII_alpha 10347170
LTP
0.23
 - -
0.60
 --
S 1081 SDPTGALTEDSIDDTFLPVPE - 18669648
HTP
0.23
 - -
0.60
 --
T 1085 GALTEDSIDDTFLPVPEYINQ - 18669648
HTP
0.17
 - -
0.53
 --
Y 1092 IDDTFLPVPEYINQSVPKRPA EGFR 8845374
LTP
0.05
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2		 -
0.57
 --
Y 1092 IDDTFLPVPEYINQSVPKRPA - 15302935
HTP
0.05
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2		 -
0.57
 --
Y 1092 IDDTFLPVPEYINQSVPKRPA - 17081983
HTP
0.05
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2		 -
0.57
 --
Y 1092 IDDTFLPVPEYINQSVPKRPA - 18083107
HTP
0.05
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2		 -
0.57
 --
S 1104 NQSVPKRPAGSVQNPVYHNQP - 17081983
HTP
0.07
 - -
0.71
 --
Y 1110 RPAGSVQNPVYHNQPLNPAPS EGFR 8845374
LTP
1.00
 GRB2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 PTB;
Src SH2;
STAT3 SH2		 -
0.80
 --
Y 1110 RPAGSVQNPVYHNQPLNPAPS - 15302935
HTP
1.00
 GRB2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 PTB;
Src SH2;
STAT3 SH2		 -
0.80
 --
Y 1125 LNPAPSRDPHYQDPHSTAVGN SRC 8845374
LTP
1.00
 PLCG1 SH2;
RASA_group SH2;
Src SH2		 -
0.86
 --
Y 1125 LNPAPSRDPHYQDPHSTAVGN SRC 11983694
LTP
1.00
 PLCG1 SH2;
RASA_group SH2;
Src SH2		 -
0.86
 --
Y 1125 LNPAPSRDPHYQDPHSTAVGN SRC 10075741
LTP
1.00
 PLCG1 SH2;
RASA_group SH2;
Src SH2		 -
0.86
 --
S 1166 HWAQKGSHQISLDNPDYQQDF - 15302935
HTP
0.25
 - -
0.64
 --
S 1166 HWAQKGSHQISLDNPDYQQDF CaM-KII_alpha 10347170
LTP
0.25
 - -
0.64
 --
S 1166 HWAQKGSHQISLDNPDYQQDF - 18669648
HTP
0.25
 - -
0.64
 --
Y 1172 SHQISLDNPDYQQDFFPKEAK EGFR 8845374
LTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2		 -
0.67
 --
Y 1172 SHQISLDNPDYQQDFFPKEAK - 15302935
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2		 -
0.67
 --
Y 1172 SHQISLDNPDYQQDFFPKEAK - 17081983
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2		 -
0.67
 --
Y 1172 SHQISLDNPDYQQDFFPKEAK - 18083107
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2		 -
0.67
 --
S 1190 EAKPNGIFKGSTAENAEYLRV - 15302935
HTP
0.00
 - -
0.58
 --
Y 1197 FKGSTAENAEYLRVAPQSSEF EGFR 8845374
LTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2		 -
0.54
 --
Y 1197 FKGSTAENAEYLRVAPQSSEF - 15302935
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2		 -
0.54
 --
Y 1197 FKGSTAENAEYLRVAPQSSEF - 17081983
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2		 -
0.54
 --
Y 1197 FKGSTAENAEYLRVAPQSSEF - 18083107
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2		 -
0.54
 --

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