Substrate: LCK (proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase))
Seq-ID: P06239 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15516   CBL_HUMAN
MINT-56730   KSYK_HUMAN
MINT-59474   LCP2_HUMAN
MINT-59476   ZAP70_HUMAN
MINT-60779   MK01_HUMAN
MINT-60782   CD3Z_HUMAN
MINT-61276   G3BP1_HUMAN
MINT-66002   CD4_HUMAN
MINT-66003   P85A_HUMAN
MINT-68489   DLG1_HUMAN
MINT-3373863   HS90A_HUMAN
MINT-3373920   GCR_HUMAN
MINT-7135817   SH22A_HUMAN
MINT-7212471   KHDR1_HUMAN
MINT-7212499   WASP_HUMAN
MINT-7218109   ADA15_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
protein C-terminus binding,
protein kinase binding,
protein serine/threonine phosphatase activity,
glycoprotein binding,
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
CD8 receptor binding,
ATPase binding,
CD4 receptor binding,
SH2 domain binding		 plasma membrane,
cytosol,
Golgi apparatus,
membrane raft,
pericentriolar material		 protein amino acid phosphorylation,
T cell differentiation,
response to drug,
activation of caspase activity,
positive regulation of T cell activation,
positive regulation of T cell receptor signaling pathway,
release of sequestered calcium ion into cytosol,
interspecies interaction between organisms,
cellular zinc ion homeostasis,
induction of apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 42 GKGTLLIRNGSEVRDPLVTYE MAPK1 8226850
LTP
0.25
 - -
0.40
 --
S 42 GKGTLLIRNGSEVRDPLVTYE MAPK3 8226850
LTP
0.25
 - -
0.40
 --
S 42 GKGTLLIRNGSEVRDPLVTYE MAPK1 8506364
LTP
0.25
 - -
0.40
 --
S 42 GKGTLLIRNGSEVRDPLVTYE MAPK3 8506364
LTP
0.25
 - -
0.40
 --
S 59 VTYEGSNPPASPLQDNLVIAL - 15199125
LTP
0.43
 - -
0.43
 2IIM 55.74%
S 158 HGSFLIRESESTAGSFSLSVR - 8262984
LTP
0.04
 - SH2
0.29
 1LKK 80.33%
S 162 LIRESESTAGSFSLSVRDFDQ - 17192257
HTP
0.80
 - SH2
0.35
 1LKK 12.30%
Y 192 KIRNLDNGGFYISPRITFPGL - 15659558
HTP
1.00
 PLCG1 SH2 SH2
0.20
 1LKK 20.09%
Y 192 KIRNLDNGGFYISPRITFPGL - 17192257
HTP
1.00
 PLCG1 SH2 SH2
0.20
 1LKK 20.09%
Y 192 KIRNLDNGGFYISPRITFPGL - 18083107
HTP
1.00
 PLCG1 SH2 SH2
0.20
 1LKK 20.09%
S 194 RNLDNGGFYISPRITFPGLHE - 8262984
LTP
0.89
 - SH2
0.21
 1LKK 18.85%
S 213 HELVRHYTNASDGLCTRLSRP - 17192257
HTP
0.43
 - SH2
0.31
 1LKK 38.52%
Y 394 GLARLIEDNEYTAREGAKFPI Lck 3265417
LTP
0.84
 Csk SH2 TyrKc
0.18
 3LCK 54.59%
Y 394 GLARLIEDNEYTAREGAKFPI - 15592455
HTP
0.84
 Csk SH2 TyrKc
0.18
 3LCK 54.59%
Y 394 GLARLIEDNEYTAREGAKFPI - 15659558
HTP
0.84
 Csk SH2 TyrKc
0.18
 3LCK 54.59%
Y 394 GLARLIEDNEYTAREGAKFPI - 17192257
HTP
0.84
 Csk SH2 TyrKc
0.18
 3LCK 54.59%
T 501 RSVLEDFFTATEGQYQPQP   - 17192257
HTP
1.00
 - -
0.39
 3LCK 53.42%
Y 505 EDFFTATEGQYQPQP       - 3265417
LTP
0.96
 Lck SH2;
Src SH2;
SYK SH2		 -
0.49
 --
Y 505 EDFFTATEGQYQPQP       - 15592455
HTP
0.96
 Lck SH2;
Src SH2;
SYK SH2		 -
0.49
 --
Y 505 EDFFTATEGQYQPQP       Lck 8945479
LTP
0.96
 Lck SH2;
Src SH2;
SYK SH2		 -
0.49
 --
Y 505 EDFFTATEGQYQPQP       - 17192257
HTP
0.96
 Lck SH2;
Src SH2;
SYK SH2		 -
0.49
 --
Y 505 EDFFTATEGQYQPQP       - 18083107
HTP
0.96
 Lck SH2;
Src SH2;
SYK SH2		 -
0.49
 --

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