Substrate: RB (retinoblastoma-associated protein (pp110) (p105-RB) (RB) (from PhosphoBase))
Seq-ID: P06400 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13924   CUX1_HUMAN
MINT-25007   LT_SV40
MINT-73396   HDAC2_HUMAN
MINT-77770   MCM7_HUMAN
MINT-1776635   MDM2_HUMAN
MINT-4793646   E2F2_HUMAN
MINT-4793665   E2F1_HUMAN
MINT-4793727   CHK2_HUMAN
MINT-4793746   CHK1_HUMAN
MINT-4793793   MK14_HUMAN
MINT-6628399   E2F3_HUMAN
MINT-6628404   HDAC1_HUMAN
MINT-6628409   RBBP8_HUMAN
MINT-6665112   E1A_ADE05
MINT-7384113   VE7_HPV16
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription repressor activity,
ubiquitin protein ligase binding,
androgen receptor binding,
kinase binding,
transcription coactivator activity,
sequence-specific DNA binding transcription factor activity,
phosphoprotein binding		 chromatin,
Rb-E2F complex,
SWI/SNF complex,
PML body		 negative regulation of transcription factor activity,
transcription,
mitotic cell cycle G1/S transition checkpoint,
regulation of transcription involved in G1/S phase of mitotic cell cycle,
negative regulation of cell growth,
cell cycle arrest,
regulation of lipid kinase activity,
G1 phase,
negative regulation of S phase of mitotic cell cycle,
myoblast differentiation,
M phase,
androgen receptor signaling pathway,
chromatin remodeling,
interspecies interaction between organisms,
Ras protein signal transduction,
negative regulation of protein kinase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 37 PPPEEDPEQDSGPEDLPLVRL - 18669648
HTP
1.00
 - -
0.86
 --
S 249 YKTAVIPINGSPRTPRRGQNR CDK_group 1756735
LTP
0.08
 MOD_CDK_SPxK_1
 - -
0.51
 --
S 249 YKTAVIPINGSPRTPRRGQNR - 18220336
HTP
0.08
 MOD_CDK_SPxK_1
 - -
0.51
 --
S 249 YKTAVIPINGSPRTPRRGQNR - 18669648
HTP
0.08
 MOD_CDK_SPxK_1
 - -
0.51
 --
T 252 AVIPINGSPRTPRRGQNRSAR CDK_group 1756735
LTP
1.00
 MOD_CDK_SPxK_1
 - -
0.52
 --
T 252 AVIPINGSPRTPRRGQNRSAR - 18220336
HTP
1.00
 MOD_CDK_SPxK_1
 - -
0.52
 --
T 252 AVIPINGSPRTPRRGQNRSAR - 18669648
HTP
1.00
 MOD_CDK_SPxK_1
 - -
0.52
 --
T 353 LQTDSIDSFETQRTPRKSNLD - 18669648
HTP
0.00
 - -
0.60
 2QDJ 6.85%
T 356 DSIDSFETQRTPRKSNLDEEV - 18220336
HTP
1.00
 - -
0.56
 --
T 356 DSIDSFETQRTPRKSNLDEEV - 18669648
HTP
1.00
 - -
0.56
 --
T 373 DEEVNVIPPHTPVRTVMNTIQ CDK_group 1756735
LTP
1.00
 MOD_CDK_SPxK_1
 - RB_A
0.42
 --
T 373 DEEVNVIPPHTPVRTVMNTIQ - 18220336
HTP
1.00
 MOD_CDK_SPxK_1
 - RB_A
0.42
 --
Y 606 LQNNHTAADMYLSPVRSPKKK - 18669648
HTP
1.00
 - -
0.50
 --
S 612 AADMYLSPVRSPKKKGSTTRV - 18669648
HTP
0.22
 - -
0.50
 --
S 807 LRIPGGNIYISPLKSPYKISE CDK_group 1756735
LTP
1.00
 MOD_CDK_SPxK_1
 - Rb_C
0.29
 --
S 807 LRIPGGNIYISPLKSPYKISE - 18669648
HTP
1.00
 MOD_CDK_SPxK_1
 - Rb_C
0.29
 --
S 811 GGNIYISPLKSPYKISEGLPT CDK_group 1756735
LTP
1.00
 MOD_CDK_SPxK_1
 - Rb_C
0.34
 --
S 811 GGNIYISPLKSPYKISEGLPT - 18669648
HTP
1.00
 MOD_CDK_SPxK_1
 - Rb_C
0.34
 --
Y 813 NIYISPLKSPYKISEGLPTPT - 18669648
HTP
0.22
 - Rb_C
0.40
 --
T 821 SPYKISEGLPTPTKMTPRSRI - 18669648
HTP
0.87
 - Rb_C
0.55
 --
T 823 YKISEGLPTPTKMTPRSRILV - 18669648
HTP
0.46
 - Rb_C
0.53
 --
T 826 SEGLPTPTKMTPRSRILVSIG - 18669648
HTP
1.00
 - Rb_C
0.52
 --
S 855 FQKINQMVCNSDRVLKRSAEG - 18669648
HTP
1.00
 - Rb_C
0.55
 2AZE 65.57%

Valid HTML 4.01 Transitional