Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

CD45 (Receptor tyrosine phosphatase)

Seq-ID:

P06800 [Mus musculus]

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Interaction Network(s):

-

External Source(s):

Phosida

Phosida

MINT Interaction(s):

[show]

MINT-13640 JAK1_MOUSE
MINT-17285 JAK2_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein tyrosine phosphatase activity, protein kinase binding, heparan sulfate proteoglycan binding, heparin binding	external side of plasma membrane, integral to plasma membrane, membrane raft, focal adhesion	positive regulation of MAPKKK cascade, positive thymic T cell selection, defense response to virus, negative regulation of peptidyl-tyrosine phosphorylation, protein amino acid dephosphorylation, positive regulation of antigen receptor-mediated signaling pathway, positive regulation of apoptosis, positive regulation of gamma-delta T cell differentiation, activation of MAPK activity, release of sequestered calcium ion into cytosol, negative regulation of T cell mediated cytotoxicity, positive regulation of humoral immune response mediated by circulating immunoglobulin, T cell receptor signaling pathway, regulation of B cell receptor signaling pathway, T cell proliferation, negative regulation of protein kinase activity, heterotypic cell-cell adhesion, negative regulation of protein amino acid autophosphorylation, negative thymic T cell selection, regulation of B cell differentiation, B cell proliferation, leukocyte cell-cell adhesion, negative regulation of cytokine-mediated signaling pathway, B cell differentiation, positive regulation of isotype switching to IgG isotypes, positive regulation of T cell mediated cytotoxicity, positive regulation of B cell proliferation, B cell receptor signaling pathway, regulation of cell cycle, positive regulation of alpha-beta T cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	988	LEMSKESEPESDESSDDDSDS	CK2_alpha	10066810	LTP	1.00		-	PTPc	0.91	-	low
S	991	SKESEPESDESSDDDSDSEET	CK2_alpha	10066810	LTP	1.00		-	PTPc	0.91	-	low
S	992	KESEPESDESSDDDSDSEETS	CK2_alpha	10066810	LTP	1.00		-	PTPc	0.91	-	low
S	996	PESDESSDDDSDSEETSKYIN	CK2_alpha	10066810	LTP	1.00	MOD_CK2_1	-	PTPc	0.80	-	low
T	1265	KAQEDSRGVGTPEPTNSAEEP	-	19144319	HTP	0.01		-	-	0.92	-	low