Substrate: CD45 (Receptor tyrosine phosphatase)
Seq-ID: P06800 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13640   JAK1_MOUSE
MINT-17285   JAK2_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein tyrosine phosphatase activity,
protein kinase binding,
heparan sulfate proteoglycan binding,
heparin binding		 external side of plasma membrane,
integral to plasma membrane,
membrane raft,
focal adhesion		 positive regulation of MAPKKK cascade,
positive thymic T cell selection,
defense response to virus,
negative regulation of peptidyl-tyrosine phosphorylation,
protein amino acid dephosphorylation,
positive regulation of antigen receptor-mediated signaling pathway,
positive regulation of apoptosis,
positive regulation of gamma-delta T cell differentiation,
activation of MAPK activity,
release of sequestered calcium ion into cytosol,
negative regulation of T cell mediated cytotoxicity,
positive regulation of humoral immune response mediated by circulating immunoglobulin,
T cell receptor signaling pathway,
regulation of B cell receptor signaling pathway,
T cell proliferation,
negative regulation of protein kinase activity,
heterotypic cell-cell adhesion,
negative regulation of protein amino acid autophosphorylation,
negative thymic T cell selection,
regulation of B cell differentiation,
B cell proliferation,
leukocyte cell-cell adhesion,
negative regulation of cytokine-mediated signaling pathway,
B cell differentiation,
positive regulation of isotype switching to IgG isotypes,
positive regulation of T cell mediated cytotoxicity,
positive regulation of B cell proliferation,
B cell receptor signaling pathway,
regulation of cell cycle,
positive regulation of alpha-beta T cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 988 LEMSKESEPESDESSDDDSDS CK2_alpha 10066810
LTP
1.00
 - PTPc
0.91
 - low
S 991 SKESEPESDESSDDDSDSEET CK2_alpha 10066810
LTP
1.00
 - PTPc
0.91
 - low
S 992 KESEPESDESSDDDSDSEETS CK2_alpha 10066810
LTP
1.00
 - PTPc
0.91
 - low
S 996 PESDESSDDDSDSEETSKYIN CK2_alpha 10066810
LTP
1.00
 MOD_CK2_1
 - PTPc
0.80
 - low
T 1265 KAQEDSRGVGTPEPTNSAEEP - 19144319
HTP
0.01
 - -
0.92
 - low

Substrate: CD45 (Receptor tyrosine phosphatase)
Seq-ID: P08575 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase binding,
transmembrane receptor protein tyrosine phosphatase activity		 focal adhesion,
integral to plasma membrane,
membrane raft		 positive regulation of B cell proliferation,
B cell receptor signaling pathway,
regulation of S phase,
immunoglobulin biosynthetic process,
defense response to virus,
protein amino acid dephosphorylation,
positive regulation of antigen receptor-mediated signaling pathway,
release of sequestered calcium ion into cytosol,
negative regulation of T cell mediated cytotoxicity,
T cell receptor signaling pathway,
negative regulation of protein kinase activity,
B cell proliferation,
negative regulation of cytokine-mediated signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 995 LKHELEMSKESEHDSDESSDD - 15302935
HTP
1.00
 - PTPc
0.81
 - medium
S 999 LEMSKESEHDSDESSDDDSDS CK2_group 10066810
LTP
1.00
 - PTPc
0.90
 - medium
S 999 LEMSKESEHDSDESSDDDSDS CK2_alpha 10066810
LTP
1.00
 - PTPc
0.90
 - medium
S 1002 SKESEHDSDESSDDDSDSEEP CK2_group 10066810
LTP
1.00
 - PTPc
0.92
 - medium
S 1002 SKESEHDSDESSDDDSDSEEP CK2_alpha 10066810
LTP
1.00
 - PTPc
0.92
 - medium
S 1003 KESEHDSDESSDDDSDSEEPS CK2_group 10066810
LTP
1.00
 - PTPc
0.92
 - medium
S 1003 KESEHDSDESSDDDSDSEEPS CK2_alpha 10066810
LTP
1.00
 - PTPc
0.92
 - medium
S 1007 HDSDESSDDDSDSEEPSKYIN CK2_alpha 10066810
LTP
1.00
 MOD_CK2_1
 - PTPc
0.81
 - medium
S 1007 HDSDESSDDDSDSEEPSKYIN PKC_group 9111075
LTP
1.00
 MOD_CK2_1
 - PTPc
0.81
 - medium
Y 1216 RPGMVSTFEQYQFLYDVIAST Csk 7507203
LTP
1.00
 Lck SH2 PTPc
0.26
 - medium

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