Substrate: TOP1 (DNA topoisomerase type I activity)
Seq-ID: P11387 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-72952   LT_SV40
MINT-73226   NUCL_HUMAN
MINT-3379396   TOPB1_HUMAN
MINT-7301011   ABL1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA topoisomerase type I activity,
DNA topoisomerase (ATP-hydrolyzing) activity,
chromatin binding,
ATP binding,
protein binding		 chromosome,
nucleolus,
nucleoplasm		 response to drug,
phosphorylation,
DNA unwinding involved in replication,
interspecies interaction between organisms,
programmed cell death
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 10  MSGDHLHNDSQIEADFRLND - 17081983
HTP
0.46
 - -
0.89
 --
S 112 IKKEKENGFSSPPQIKDEPED - 18669648
HTP
0.45
 - -
0.83
 --
Y 268 TFFAKMLDHEYTTKEIFRKNF Abl 15448168
LTP
1.00
 - Topoisom_I_N
0.20
 1A31 10.92%

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