Substrate: TOP1 (DNA topoisomerase type I activity)
Seq-ID: P11387 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-72952   LT_SV40
MINT-73226   NUCL_HUMAN
MINT-3379396   TOPB1_HUMAN
MINT-7301011   ABL1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA topoisomerase type I activity,
DNA topoisomerase (ATP-hydrolyzing) activity,
chromatin binding,
ATP binding,
protein binding		 chromosome,
nucleolus,
nucleoplasm		 response to drug,
phosphorylation,
DNA unwinding involved in replication,
interspecies interaction between organisms,
programmed cell death
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 10  MSGDHLHNDSQIEADFRLND - 17081983
HTP
0.46
 - -
0.89
 --
S 112 IKKEKENGFSSPPQIKDEPED - 18669648
HTP
0.45
 - -
0.83
 --
Y 268 TFFAKMLDHEYTTKEIFRKNF Abl 15448168
LTP
1.00
 - Topoisom_I_N
0.20
 1A31 10.92%

Substrate: TOP1 (DNA topoisomerase type I activity)
Seq-ID: P30189 [Drosophila melanogaster]
Download:fasta csv
Interaction Network(s):
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA topoisomerase type I activity,
DNA topoisomerase (ATP-hydrolyzing) activity,
ATP binding,
protein binding		 nuclear euchromatin,
cytoplasm,
microtubule associated complex,
nucleolus,
polytene chromosome puff		 chromosome segregation,
DNA unwinding involved in replication,
oogenesis,
instar larval development,
DNA topological change,
chromosome condensation,
cell proliferation,
embryo development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 303 EPPFVVKHEQSYAEEDSTMNY - 18327897
HTP
0.56
 - -
0.72
 - medium
S 303 EPPFVVKHEQSYAEEDSTMNY - 18327897
HTP
0.56
 - -
0.72
 - medium
Y 304 PPFVVKHEQSYAEEDSTMNYN - 18327897
HTP
0.50
 - -
0.72
 - medium
Y 304 PPFVVKHEQSYAEEDSTMNYN - 18327897
HTP
0.50
 - -
0.72
 - medium

Substrate: TOP1 (DNA topoisomerase type I activity)
Seq-ID: Q04750 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-2568559   TAL1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA topoisomerase type I activity,
DNA topoisomerase (ATP-hydrolyzing) activity,
ATP binding		 perikaryon,
cytoplasm,
nucleolus,
nucleoplasm		 embryonic cleavage,
DNA topological change,
DNA replication
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 270 TFFAKMLDHEYTTKEIFRKNF - 15448168
LTP
1.00
 - Topoisom_I_N
0.21
 - medium

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