Substrate: PML (protein binding)
Seq-ID: P29590 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-4793330   MDM2_HUMAN
MINT-4793489   P53_HUMAN
MINT-6743913   TOP3A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
DNA binding,
protein homodimerization activity,
ubiquitin protein ligase binding,
transcription coactivator activity,
zinc ion binding,
protein binding,
transcription repressor activity,
cobalt ion binding		 cytoplasm,
nuclear membrane,
nucleolus,
nuclear matrix,
insoluble fraction,
nucleus,
PML body		 protein stabilization,
negative regulation of angiogenesis,
negative regulation of cell proliferation,
negative regulation of cell growth,
cell cycle arrest,
positive regulation of histone deacetylation,
negative regulation of transcription,
PML body organization,
response to cytokine stimulus,
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis,
interspecies interaction between organisms,
protein targeting,
maintenance of protein location in nucleus,
negative regulation of mitotic cell cycle,
induction of apoptosis,
DNA damage response, signal transduction resulting in induction of apoptosis,
negative regulation of translation in response to oxidative stress,
positive regulation of defense response to virus by host,
protein complex assembly,
transcription,
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest,
response to hypoxia
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 38 TPSEGRQPSPSPSPTERAPAS HIPK2 19015637
LTP
1.00
 - -
0.95
 - medium
S 403 GKDAAVSKKASPEAASTPRDP - 18669648
HTP
0.11
 - -
0.74
 - medium
T 409 SKKASPEAASTPRDPIDVDLP - 18669648
HTP
1.00
 - -
0.75
 - medium
S 505 EGKEARLARSSPEQPRPSTSK - 17287340
HTP
1.00
 - -
0.90
 - medium
S 512 ARSSPEQPRPSTSKAVSPPHL - 17287340
HTP
1.00
 - -
0.92
 - medium
S 518 QPRPSTSKAVSPPHLDGPPSP - 18669648
HTP
1.00
 - -
0.95
 - medium
S 527 VSPPHLDGPPSPRSPVIGSEV - 18669648
HTP
1.00
 - -
0.81
 - medium
S 530 PHLDGPPSPRSPVIGSEVFLP - 17081983
HTP
1.00
 - -
0.77
 - medium
S 530 PHLDGPPSPRSPVIGSEVFLP - 18669648
HTP
1.00
 - -
0.77
 - medium
S 535 PPSPRSPVIGSEVFLPNSNHV - 18669648
HTP
0.04
 - -
0.70
 - medium
S 578 ENSSSRELDDSSSESSDLQLE - 17081983
HTP
0.42
 - -
0.78
 - medium
S 579 NSSSRELDDSSSESSDLQLEG - 17081983
HTP
0.42
 - -
0.76
 - medium
S 580 SSSRELDDSSSESSDLQLEGP - 17081983
HTP
0.71
 - -
0.76
 - medium

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