Substrate: PKB-alpha (RAC-alpha serine/threonine kinase (EC 2.7.1.-) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT))
Seq-ID: P31749 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphatidylinositol-3,4-bisphosphate binding,
protein serine/threonine kinase activity,
phosphatidylinositol-3,4,5-trisphosphate binding,
identical protein binding,
nitric-oxide synthase regulator activity,
ATP binding,
enzyme binding
plasma membrane,
cytosol,
nucleoplasm
response to UV-A,
positive regulation of cell growth,
regulation of neuron projection development,
positive regulation of cyclin-dependent protein kinase activity involved in G1/S,
glycogen biosynthetic process,
response to heat,
negative regulation of fatty acid beta-oxidation,
insulin-like growth factor receptor signaling pathway,
peptidyl-serine phosphorylation,
regulation of translation,
protein amino acid autophosphorylation,
positive regulation of nitric-oxide synthase activity,
nitric oxide biosynthetic process,
positive regulation of fat cell differentiation,
positive regulation of glycogen biosynthetic process,
positive regulation of lipid biosynthetic process,
activation of pro-apoptotic gene products,
negative regulation of plasma membrane long-chain fatty acid transport,
positive regulation of establishment of protein localization in plasma membrane,
insulin receptor signaling pathway,
positive regulation of glucose import,
negative regulation of protein kinase activity,
response to fluid shear stress,
activation-induced cell death of T cells,
protein import into nucleus, translocation,
G-protein coupled receptor protein signaling pathway,
positive regulation of nitric oxide biosynthetic process
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 122 KQEEEEMDFRSGSPSDNSGAE - 18669648
HTP
0.37
- -
0.74
--
S 124 EEEEMDFRSGSPSDNSGAEEM - 12149249
LTP
0.89
- -
0.72
--
S 124 EEEEMDFRSGSPSDNSGAEEM - 18669648
HTP
0.89
- -
0.72
--
S 126 EEMDFRSGSPSDNSGAEEMEV - 18669648
HTP
0.42
- -
0.66
--
S 129 DFRSGSPSDNSGAEEMEVSLA CK2_alpha 15818404
LTP
0.53
MOD_CK2_1
- -
0.63
--
S 129 DFRSGSPSDNSGAEEMEVSLA - 18669648
HTP
0.53
MOD_CK2_1
- -
0.63
--
T 308 EGIKDGATMKTFCGTPEYLAP PDK-1 9868760
LTP
1.00
- S_TKc
0.22
3CQU 71.92%
T 308 EGIKDGATMKTFCGTPEYLAP PDK-1 15718470
LTP
1.00
- S_TKc
0.22
3CQU 71.92%
T 450 EEFTAQMITITPPDQDDSMEC - 12149249
LTP
0.96
- S_TK_X
0.56
--
S 473 SERRPHFPQFSYSASGTA    ILK 11313365
LTP
0.95
- S_TK_X
0.52
3CQU 51.66%
S 473 SERRPHFPQFSYSASGTA    PDK-1 10226025
LTP
0.95
- S_TK_X
0.52
3CQU 51.66%
Y 474 ERRPHFPQFSYSASGTA     - 12149249
LTP
0.94
- S_TK_X
0.52
3CQU 18.34%

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