Substrate: PKB-alpha (RAC-alpha serine/threonine kinase (EC 2.7.1.-) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT))
Seq-ID: P31749 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13835   PDPK1_HUMAN
MINT-15213   KS6B1_HUMAN
MINT-16737   FRAP_HUMAN
MINT-17680   CDN1B_HUMAN
MINT-74931   PP2AA_HUMAN
MINT-3379039   TOPB1_HUMAN
MINT-4820691   CASP3_HUMAN
MINT-6175251   STK4_HUMAN
MINT-6742762   TERT_HUMAN
MINT-6823537   MDM2_HUMAN
MINT-7014449   RAF1_HUMAN
MINT-7146767   PLCG1_HUMAN
MINT-7232672   KPCZ_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphatidylinositol-3,4-bisphosphate binding,
protein serine/threonine kinase activity,
phosphatidylinositol-3,4,5-trisphosphate binding,
identical protein binding,
nitric-oxide synthase regulator activity,
ATP binding,
enzyme binding		 plasma membrane,
cytosol,
nucleoplasm		 response to UV-A,
positive regulation of cell growth,
regulation of neuron projection development,
positive regulation of cyclin-dependent protein kinase activity involved in G1/S,
glycogen biosynthetic process,
response to heat,
negative regulation of fatty acid beta-oxidation,
insulin-like growth factor receptor signaling pathway,
peptidyl-serine phosphorylation,
regulation of translation,
protein amino acid autophosphorylation,
positive regulation of nitric-oxide synthase activity,
nitric oxide biosynthetic process,
positive regulation of fat cell differentiation,
positive regulation of glycogen biosynthetic process,
positive regulation of lipid biosynthetic process,
activation of pro-apoptotic gene products,
negative regulation of plasma membrane long-chain fatty acid transport,
positive regulation of establishment of protein localization in plasma membrane,
insulin receptor signaling pathway,
positive regulation of glucose import,
negative regulation of protein kinase activity,
response to fluid shear stress,
activation-induced cell death of T cells,
protein import into nucleus, translocation,
G-protein coupled receptor protein signaling pathway,
positive regulation of nitric oxide biosynthetic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 122 KQEEEEMDFRSGSPSDNSGAE - 18669648
HTP
0.37
 - -
0.74
 --
S 124 EEEEMDFRSGSPSDNSGAEEM - 12149249
LTP
0.89
 - -
0.72
 --
S 124 EEEEMDFRSGSPSDNSGAEEM - 18669648
HTP
0.89
 - -
0.72
 --
S 126 EEMDFRSGSPSDNSGAEEMEV - 18669648
HTP
0.42
 - -
0.66
 --
S 129 DFRSGSPSDNSGAEEMEVSLA CK2_alpha 15818404
LTP
0.53
 MOD_CK2_1
 - -
0.63
 --
S 129 DFRSGSPSDNSGAEEMEVSLA - 18669648
HTP
0.53
 MOD_CK2_1
 - -
0.63
 --
T 308 EGIKDGATMKTFCGTPEYLAP PDK-1 9868760
LTP
1.00
 - S_TKc
0.22
 3CQU 71.92%
T 308 EGIKDGATMKTFCGTPEYLAP PDK-1 15718470
LTP
1.00
 - S_TKc
0.22
 3CQU 71.92%
T 450 EEFTAQMITITPPDQDDSMEC - 12149249
LTP
0.96
 - S_TK_X
0.56
 --
S 473 SERRPHFPQFSYSASGTA    ILK 11313365
LTP
0.95
 - S_TK_X
0.52
 3CQU 51.66%
S 473 SERRPHFPQFSYSASGTA    PDK-1 10226025
LTP
0.95
 - S_TK_X
0.52
 3CQU 51.66%
Y 474 ERRPHFPQFSYSASGTA     - 12149249
LTP
0.94
 - S_TK_X
0.52
 3CQU 18.34%

Substrate: PKB-alpha (RAC-alpha serine/threonine kinase (EC 2.7.1.-) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT))
Seq-ID: P31750 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-4049581   PDE3A_MOUSE
MINT-6175057   STK4_HUMAN
MINT-6793722   PTN1_HUMAN
MINT-6978911   HS90A_MOUSE
MINT-6978941   UBIQ_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding		 plasma membrane,
spindle,
cytosol,
lamellipodium,
nucleus		 response to food,
glycogen cell development involved in embryonic placenta development,
protein ubiquitination,
regulation of neuron projection development,
maternal placenta development,
glycogen biosynthetic process,
apoptotic mitochondrial changes,
germ cell development,
inflammatory response,
insulin-like growth factor receptor signaling pathway,
peptidyl-serine phosphorylation,
positive regulation of proteasomal ubiquitin-dependent protein catabolic process,
anagen,
positive regulation of sodium ion transport,
regulation of translation,
labyrinthine layer blood vessel development,
protein catabolic process,
protein kinase B signaling cascade,
glucose transport,
insulin receptor signaling pathway,
regulation of survival gene product expression
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 124 EEETMDFRSGSPSDNSGAEEM - 17242355
HTP
0.89
 - -
0.72
 - medium
S 126 ETMDFRSGSPSDNSGAEEMEV - 17242355
HTP
0.42
 - -
0.65
 - medium
S 129 DFRSGSPSDNSGAEEMEVSLA - 17242355
HTP
0.53
 - -
0.62
 - medium
T 308 EGIKDGATMKTFCGTPEYLAP - 15364915
LTP
1.00
 - S_TKc
0.22
 - medium
T 308 EGIKDGATMKTFCGTPEYLAP PDK-1 12682057
LTP
1.00
 - S_TKc
0.22
 - medium
T 308 EGIKDGATMKTFCGTPEYLAP - 11087733
LTP
1.00
 - S_TKc
0.22
 - medium
T 308 EGIKDGATMKTFCGTPEYLAP PDK-1 19047061
LTP
1.00
 - S_TKc
0.22
 - medium
T 308 EGIKDGATMKTFCGTPEYLAP - 17141160
LTP
1.00
 - S_TKc
0.22
 - medium
Y 315 TMKTFCGTPEYLAPEVLEDND SRC 11445557
LTP
1.00
 - S_TKc
0.25
 - medium
Y 326 LAPEVLEDNDYGRAVDWWGLG SRC 11445557
LTP
1.00
 - S_TKc
0.10
 - medium
S 473 SERRPHFPQFSYSASGTA    mTOR 16221682
LTP
0.95
 - S_TK_X
0.53
 - medium
S 473 SERRPHFPQFSYSASGTA    - 15364915
LTP
0.95
 - S_TK_X
0.53
 - medium
S 473 SERRPHFPQFSYSASGTA    - 17141160
LTP
0.95
 - S_TK_X
0.53
 - medium

Substrate: PKB-alpha (RAC-alpha serine/threonine kinase (EC 2.7.1.-) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT))
Seq-ID: Q8INB9 [Drosophila melanogaster]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-7955052   ENA_DROME
MINT-7962908   FRY_DROME
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
phosphoinositide binding,
ATP binding,
protein binding		 plasma membrane,
cytosol,
cell surface		 intracellular signaling pathway,
protein amino acid phosphorylation,
positive regulation of cell growth,
positive regulation of organ growth,
apoptosis,
anti-apoptosis,
lipid storage,
regulation of cell shape,
positive regulation of multicellular organism growth,
regulation of dendrite development,
epithelial cell migration, open tracheal system,
insulin receptor signaling pathway,
chitin-based embryonic cuticle biosynthetic process,
regulation of protein import into nucleus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 30 APGSASRIPESPTTTGSNIIN - 18327897
HTP
 - - -
0.65
 - medium
S 30 APGSASRIPESPTTTGSNIIN - 18327897
HTP
 - - -
0.65
 - medium
S 586 IAEEPLFPQFSYQGDMASTLG - 15718470
LTP
1.00
 - S_TK_X
0.45
 - medium
S 586 IAEEPLFPQFSYQGDMASTLG - 10962553
LTP
1.00
 - S_TK_X
0.45
 - medium

Valid HTML 4.01 Transitional