Substrate: BRCA1 (Breast cancer type 1 susceptibility protein)
Seq-ID: P38398 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13705   JAK2_HUMAN
MINT-13786   ESR1_HUMAN
MINT-14573   SMC1A_HUMAN
MINT-16089   BRAP_HUMAN
MINT-16161   P53_HUMAN
MINT-16217   CREB1_HUMAN
MINT-16582   JAK1_HUMAN
MINT-19473   FACD2_HUMAN
MINT-19477   FANCA_HUMAN
MINT-25055   BARD1_HUMAN
MINT-77954   VE7_HPV16
MINT-2490745   H4_HUMAN
MINT-2791487   RD23B_HUMAN
MINT-5115454   FANCJ_HUMAN
MINT-7213847   ABL1_HUMAN
MINT-7250578   NCK1_HUMAN
MINT-7251658   P85A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
identical protein binding,
ubiquitin protein ligase binding,
androgen receptor binding,
RNA binding,
transcription coactivator activity,
zinc ion binding,
tubulin binding,
ubiquitin-protein ligase activity		 ribonucleoprotein complex,
gamma-tubulin ring complex,
nucleoplasm,
BRCA1-BARD1 complex,
BRCA1-A complex		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
negative regulation of centriole replication,
response to estrogen stimulus,
apoptosis,
chromosome segregation,
cellular response to indole-3-methanol,
fatty acid biosynthetic process,
regulation of transcription from RNA polymerase III promoter,
cell cycle,
postreplication repair,
G2/M transition DNA damage checkpoint,
positive regulation of protein ubiquitination,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
negative regulation of transcription,
positive regulation of DNA repair,
negative regulation of fatty acid biosynthetic process,
androgen receptor signaling pathway,
regulation of cell proliferation,
protein K6-linked ubiquitination,
DNA damage response, signal transduction resulting in induction of apoptosis,
double-strand break repair via homologous recombination,
response to ionizing radiation,
protein autoubiquitination
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 308 NVEKAEFCNKSKQPGLARSQH Aurora A 14990569
LTP
1.00
 - -
0.61
 --
S 395 WFSRSDELLGSDDSHDGESES - 18669648
HTP
1.00
 - -
0.63
 --
S 398 RSDELLGSDDSHDGESESNAK - 18669648
HTP
1.00
 - -
0.68
 --
S 403 LGSDDSHDGESESNAKVADVL - 18669648
HTP
1.00
 - -
0.64
 --
S 405 SDDSHDGESESNAKVADVLDV - 18669648
HTP
0.83
 - -
0.60
 --
T 509 TNKLKRKRRPTSGLHPEDFIK PKB_group 10542266
LTP
1.00
 MOD_PKB_1
 - -
0.65
 --
S 753 NAEDPKDLMLSGERVLQTERS - 18669648
HTP
0.84
 - -
0.72
 --
S 988 YRIPPLFPIKSFVKTKCKKNL CHK2 12111733
LTP
1.00
 - -
0.34
 --
S 988 YRIPPLFPIKSFVKTKCKKNL CHK2 14701743
LTP
1.00
 - -
0.34
 --
S 1189 KSVQKGELSRSPSPFTHTHLA - 10550055
LTP
1.00
 - -
0.59
 --
S 1211 GYRRGAKKLESSEENLSSEDE - 18669648
HTP
1.00
 - -
0.68
 --
S 1212 YRRGAKKLESSEENLSSEDEE - 18669648
HTP
0.89
 - -
0.67
 --
S 1217 KKLESSEENLSSEDEELPCFQ - 18669648
HTP
1.00
 - -
0.53
 --
S 1218 KLESSEENLSSEDEELPCFQH - 18669648
HTP
1.00
 - -
0.50
 --
S 1239 LLFGKVNNIPSQSTRHSTVAT - 17525332
HTP
1.00
 - -
0.48
 --
S 1245 NNIPSQSTRHSTVATECLSKN - 17525332
HTP
0.53
 - -
0.59
 --
S 1330 SSKQMRHQSESQGVGLSDKEL ATM 10550055
LTP
0.35
 MOD_PIKK_1
 - -
0.71
 --
S 1330 SSKQMRHQSESQGVGLSDKEL - 17525332
HTP
0.35
 MOD_PIKK_1
 - -
0.71
 --
S 1336 HQSESQGVGLSDKELVSDDEE - 17081983
HTP
0.53
 - -
0.78
 --
S 1336 HQSESQGVGLSDKELVSDDEE - 17525332
HTP
0.53
 - -
0.78
 --
S 1342 GVGLSDKELVSDDEERGTGLE - 17525332
HTP
1.00
 - -
0.77
 --
S 1387 SVSEDCSGLSSQSDILTTQQR ATM 12183412
LTP
1.00
 MOD_PIKK_1
 - -
0.67
 --
S 1423 ELEAVLEQHGSQPSNSYPSII ATM 10550055
LTP
1.00
 MOD_PIKK_1
 - COIL
0.74
 --
S 1423 ELEAVLEQHGSQPSNSYPSII ATM 11278964
LTP
1.00
 MOD_PIKK_1
 - COIL
0.74
 --
S 1423 ELEAVLEQHGSQPSNSYPSII ATR 11278964
LTP
1.00
 MOD_PIKK_1
 - COIL
0.74
 --
S 1423 ELEAVLEQHGSQPSNSYPSII ATR 11114888
LTP
1.00
 MOD_PIKK_1
 - COIL
0.74
 --
S 1457 QSTSEKAVLTSQKSSEYPISQ ATM 10550055
LTP
1.00
 MOD_PIKK_1
 - -
0.74
 --
S 1457 QSTSEKAVLTSQKSSEYPISQ ATM 11278964
LTP
1.00
 MOD_PIKK_1
 - -
0.74
 --
S 1457 QSTSEKAVLTSQKSSEYPISQ ATR 11278964
LTP
1.00
 MOD_PIKK_1
 - -
0.74
 --
S 1457 QSTSEKAVLTSQKSSEYPISQ - 17525332
HTP
1.00
 MOD_PIKK_1
 - -
0.74
 --
S 1466 TSQKSSEYPISQNPEGLSADK ATM 10550055
LTP
0.91
 MOD_PIKK_1
 - -
0.70
 --
S 1466 TSQKSSEYPISQNPEGLSADK - 17525332
HTP
0.91
 MOD_PIKK_1
 - -
0.70
 --
S 1497 KNKEPGVERSSPSKCPSLDDR ATM 10550055
LTP
1.00
 MOD_CDK_SPxK_1
 - -
0.76
 --
S 1497 KNKEPGVERSSPSKCPSLDDR CDK2 10373534
LTP
1.00
 MOD_CDK_SPxK_1
 - -
0.76
 --
S 1499 KEPGVERSSPSKCPSLDDRWY - 17081983
HTP
1.00
 - -
0.69
 --
S 1524 SGSLQNRNYPSQEELIKVVDV ATM 10550055
LTP
1.00
 MOD_PIKK_1
 - -
0.62
 --
S 1524 SGSLQNRNYPSQEELIKVVDV ATM 11278964
LTP
1.00
 MOD_PIKK_1
 - -
0.62
 --
S 1524 SGSLQNRNYPSQEELIKVVDV ATR 11278964
LTP
1.00
 MOD_PIKK_1
 - -
0.62
 --
S 1524 SGSLQNRNYPSQEELIKVVDV - 17525332
HTP
1.00
 MOD_PIKK_1
 - -
0.62
 --
S 1542 VDVEEQQLEESGPHDLTETSY - 10550055
LTP
0.65
 - -
0.83
 --
S 1542 VDVEEQQLEESGPHDLTETSY - 18220336
HTP
0.65
 - -
0.83
 --
T 1700 KTDAEFVCERTLKYFLGIAGG - 17525332
HTP
1.00
 - BRCT
0.09
 1JNX 27.40%
T 1720 GKWVVSYFWVTQSIKERKMLN - 17525332
HTP
1.00
 - BRCT
0.10
 1JNX 20.55%

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