Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

p21 (Cyclin-dependent kinase inhibitor 1 (p21))

Seq-ID:

P38936 [Homo sapiens]

Download:

Interaction Network(s):

STRING

NetworKIN

External Source(s):

Phosida

MINT Interaction(s):

[show]

MINT-50392   CC45L_HUMAN
MINT-50407   CDC6_HUMAN
MINT-50418   CDK4_HUMAN
MINT-50421   CDK6_HUMAN
MINT-50432   CCNB2_HUMAN
MINT-50437   CCND1_HUMAN
MINT-50441   CCND3_HUMAN
MINT-50445   GEMI_HUMAN
MINT-50660   CCNB1_HUMAN
MINT-73322   VE7_HPV16
MINT-73323   CDK2_HUMAN
MINT-1774121   SKP2_HUMAN
MINT-1780042   MCM7_HUMAN
MINT-1891378   P53_HUMAN
MINT-2635177   CCNE1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cyclin-dependent protein kinase inhibitor activity, metal ion binding	cytosol, cyclin-dependent protein kinase holoenzyme complex, nucleoplasm, PCNA-p21 complex	cellular response to extracellular stimulus, positive regulation of fibroblast proliferation, senescence, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, negative regulation of cell proliferation, negative regulation of cell growth, cell cycle arrest, G1/S transition of mitotic cell cycle, induction of apoptosis by intracellular signals, Ras protein signal transduction, G2/M transition of mitotic cell cycle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	57	ERWNFDFVTETPLEGDFAWER	MAPK_group	12058028	LTP	1.00	MOD_ProDKin_1	-	CDI	0.36	-	medium
T	57	ERWNFDFVTETPLEGDFAWER	GSK-3_beta	11779850	LTP	1.00	MOD_ProDKin_1	-	CDI	0.36	-	medium
T	57	ERWNFDFVTETPLEGDFAWER	MAPK1	19364816	LTP	1.00	MOD_ProDKin_1	-	CDI	0.36	-	medium
S	98	ELGGGRRPGTSPALLQGTAEE	MAP3K5	17325029	LTP	0.13		-	-	0.78	-	medium
S	114	GTAEEDHVDLSLSCTLVPRSG	GSK-3_beta	17283049	LTP	0.04	MOD_GSK3_1	-	-	0.49	-	medium
S	130	VPRSGEQAEGSPGGPGDSQGR	MAPK_group	12058028	LTP	0.03	MOD_ProDKin_1	-	-	0.91	-	medium
S	130	VPRSGEQAEGSPGGPGDSQGR	CDK2	12730199	LTP	0.03	MOD_ProDKin_1	-	-	0.91	-	medium
S	130	VPRSGEQAEGSPGGPGDSQGR	-	16964243	HTP	0.03	MOD_ProDKin_1	-	-	0.91	-	medium
S	130	VPRSGEQAEGSPGGPGDSQGR	CDK2	15964852	LTP	0.03	MOD_ProDKin_1	-	-	0.91	-	medium
T	145	GDSQGRKRRQTSMTDFYHSKR	PKB_group	11756412	LTP	0.19	MOD_PKB_1	-	-	0.69	-	medium
T	145	GDSQGRKRRQTSMTDFYHSKR	PKC_alpha	15001356	LTP	0.19	MOD_PKB_1	-	-	0.69	-	medium
T	145	GDSQGRKRRQTSMTDFYHSKR	PIM-1	17855660	LTP	0.19	MOD_PKB_1	-	-	0.69	-	medium
T	145	GDSQGRKRRQTSMTDFYHSKR	PKB_group	16982699	LTP	0.19	MOD_PKB_1	-	-	0.69	-	medium
T	145	GDSQGRKRRQTSMTDFYHSKR	PKB_group	11463845	LTP	0.19	MOD_PKB_1	-	-	0.69	-	medium
S	146	DSQGRKRRQTSMTDFYHSKRR	PKB_group	11756412	LTP	0.03	MOD_PKB_1	-	-	0.65	-	medium
S	146	DSQGRKRRQTSMTDFYHSKRR	PKC_alpha	10753973	LTP	0.03	MOD_PKB_1	-	-	0.65	-	medium
S	146	DSQGRKRRQTSMTDFYHSKRR	PIM-1	17855660	LTP	0.03	MOD_PKB_1	-	-	0.65	-	medium
S	153	RQTSMTDFYHSKRRLIFSKRK	DYRK1B	15851482	LTP	0.21		-	-	0.50	-	medium