Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

SYK (Spleen tyrosine kinase )

Seq-ID:

P43405 [Homo sapiens]

Download:

Interaction Network(s):

STRING

NetworKIN

External Source(s):

Phosida

Phosida

MINT Interaction(s):

[show]

MINT-56730   LCK_HUMAN
MINT-56732   P85A_HUMAN
MINT-56739   FGR_HUMAN
MINT-56749   P85B_HUMAN
MINT-74763   EGFR_HUMAN
MINT-74769   ERBB2_HUMAN
MINT-74775   ERBB3_HUMAN
MINT-74776   ERBB4_HUMAN
MINT-6538977   CBL_HUMAN
MINT-6621148   BLNK_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
non-membrane spanning protein tyrosine kinase activity, ATP binding, integrin binding	cytoplasm, T cell receptor complex	protein complex assembly, organ morphogenesis, integrin-mediated signaling pathway, neutrophil chemotaxis, interspecies interaction between organisms, cell proliferation, leukocyte cell-cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	296	AGGIISRIKSYSFPKPGHRKS	-	18083107	HTP	-		-	-	0.41	-	-
S	297	GGIISRIKSYSFPKPGHRKSS	-	18088087	HTP	-		-	-	0.44	-	-
Y	323	RQESTVSFNPYEPELAPWAAD	-	16497976	HTP	0.80		CBLB SH2; CBL PTB; PIK3R1 SH2	-	0.51	-	-
Y	323	RQESTVSFNPYEPELAPWAAD	-	18083107	HTP	0.80		CBLB SH2; CBL PTB; PIK3R1 SH2	-	0.51	-	-
Y	348	REALPMDTEVYESPYADPEEI	SYK	8657103	LTP	0.93		FGR SH2; Lck SH2; PLCG1 SH2; VAV1 SH2	-	0.59	-	-
Y	348	REALPMDTEVYESPYADPEEI	-	12522270	HTP	0.93		FGR SH2; Lck SH2; PLCG1 SH2; VAV1 SH2	-	0.59	-	-
Y	348	REALPMDTEVYESPYADPEEI	-	18083107	HTP	0.93		FGR SH2; Lck SH2; PLCG1 SH2; VAV1 SH2	-	0.59	-	-
Y	352	PMDTEVYESPYADPEEIRPKE	SYK	8657103	LTP	1.00		FGR SH2; Lck SH2; PLCG1 SH2; VAV1 SH2	-	0.53	-	-
Y	352	PMDTEVYESPYADPEEIRPKE	-	12522270	HTP	1.00		FGR SH2; Lck SH2; PLCG1 SH2; VAV1 SH2	-	0.53	-	-
Y	352	PMDTEVYESPYADPEEIRPKE	-	18083107	HTP	1.00		FGR SH2; Lck SH2; PLCG1 SH2; VAV1 SH2	-	0.53	-	-
Y	525	LSKALRADENYYKAQTHGKWP	SYK	8657103	LTP	1.00		CBL PTB; Lck SH2	TyrKc	0.19	1XBA	41.92%
Y	526	SKALRADENYYKAQTHGKWPV	SYK	8657103	LTP	1.00		CBL PTB; Lck SH2	TyrKc	0.17	1XBA	30.57%
Y	526	SKALRADENYYKAQTHGKWPV	-	18083107	HTP	1.00		CBL PTB; Lck SH2	TyrKc	0.17	1XBA	30.57%