Substrate: SYK (Spleen tyrosine kinase )
Seq-ID: P48025 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-56734   P85A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor signaling protein tyrosine kinase activity,
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 B cell receptor complex,
cytoplasm		 positive regulation of peptidyl-tyrosine phosphorylation,
positive regulation of interleukin-3 biosynthetic process,
B cell receptor signaling pathway,
serotonin secretion,
positive regulation of alpha-beta T cell proliferation,
positive regulation of calcium-mediated signaling,
positive regulation of B cell differentiation,
activation of JUN kinase activity,
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process,
beta selection,
positive regulation of gamma-delta T cell differentiation,
positive regulation of mast cell degranulation,
leukotriene biosynthetic process,
protein amino acid autophosphorylation,
enzyme linked receptor protein signaling pathway,
peptidyl-tyrosine phosphorylation,
positive regulation of alpha-beta T cell differentiation,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 130 EDLKENLIREYVKQTWNLQGQ Lyn 9820500
LTP
1.00
 - -
0.28
 --
Y 130 EDLKENLIREYVKQTWNLQGQ SYK 9820500
LTP
1.00
 - -
0.28
 --
Y 317 RPESTVSFNPYEPTGGPWGPD - 9857068
LTP
1.00
 CBL SH2 -
0.69
 --
Y 317 RPESTVSFNPYEPTGGPWGPD Lyn 9820500
LTP
1.00
 CBL SH2 -
0.69
 --
Y 342 REALPMDTEVYESPYADPEEI SYK 8657103
LTP
1.00
 PLCG_group SH2;
VAV1 SH2		 -
0.58
 --
Y 342 REALPMDTEVYESPYADPEEI Lyn 9820500
LTP
1.00
 PLCG_group SH2;
VAV1 SH2		 -
0.58
 --
Y 346 PMDTEVYESPYADPEEIRPKE SYK 8657103
LTP
1.00
 PLCG_group SH2 -
0.54
 --
Y 346 PMDTEVYESPYADPEEIRPKE Lyn 9820500
LTP
1.00
 PLCG_group SH2 -
0.54
 --
Y 358 DPEEIRPKEVYLDRSLLTLED SYK 8657103
LTP
0.16
 - -
0.44
 1XBA 68.12%
Y 519 LSKALRADENYYKAQTHGKWP SYK 8657103
LTP
1.00
 - TyrKc
0.19
 1XBA 41.92%
Y 520 SKALRADENYYKAQTHGKWPV SYK 8657103
LTP
1.00
 - TyrKc
0.17
 1XBA 30.57%

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