Substrate: MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1))
Seq-ID: Q02750 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16002   KSR1_MOUSE
MINT-3391583   M3K1_HUMAN
MINT-4300484   MK01_HUMAN
MINT-7014370   RAF1_HUMAN
MINT-7014390   MK03_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
MAP kinase kinase activity,
ATP binding,
protein tyrosine kinase activity		 cytosol senescence,
negative regulation of cell proliferation,
cell cycle arrest,
chemotaxis,
Ras protein signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 23 PAPDGSAVNGTSSAETNLEAL MAP2K_group 7873542
LTP
0.17
 - COIL
0.69
 --
S 24 APDGSAVNGTSSAETNLEALQ MAP2K_group 7873542
LTP
0.44
 - COIL
0.65
 --
S 25 PDGSAVNGTSSAETNLEALQK MAP2K_group 7873542
LTP
0.02
 - COIL
0.63
 --
S 212 GEIKLCDFGVSGQLIDSMANS - 12506122
LTP
1.00
 - S_TKc
0.16
 3EQC 3.28%
S 218 DFGVSGQLIDSMANSFVGTRS MAP2K_group 7873542
LTP
1.00
 - S_TKc
0.20
 3EQC 29.51%
S 218 DFGVSGQLIDSMANSFVGTRS - 7936666
LTP
1.00
 - S_TKc
0.20
 3EQC 29.51%
S 218 DFGVSGQLIDSMANSFVGTRS MAP3K_group 7624324
LTP
1.00
 - S_TKc
0.20
 3EQC 29.51%
S 218 DFGVSGQLIDSMANSFVGTRS MAP3K8 15466476
LTP
1.00
 - S_TKc
0.20
 3EQC 29.51%
S 218 DFGVSGQLIDSMANSFVGTRS MAP3K_group 15466476
LTP
1.00
 - S_TKc
0.20
 3EQC 29.51%
S 218 DFGVSGQLIDSMANSFVGTRS RAF1 8131746
LTP
1.00
 - S_TKc
0.20
 3EQC 29.51%
S 222 SGQLIDSMANSFVGTRSYMSP PDK-1 15175348
LTP
1.00
 - S_TKc
0.28
 --
S 222 SGQLIDSMANSFVGTRSYMSP MAP3K_group 7624324
LTP
1.00
 - S_TKc
0.28
 --
S 222 SGQLIDSMANSFVGTRSYMSP - 8039496
LTP
1.00
 - S_TKc
0.28
 --
S 222 SGQLIDSMANSFVGTRSYMSP MAP3K8 15466476
LTP
1.00
 - S_TKc
0.28
 --
S 222 SGQLIDSMANSFVGTRSYMSP MAP3K_group 15466476
LTP
1.00
 - S_TKc
0.28
 --
S 222 SGQLIDSMANSFVGTRSYMSP RAF1 8131746
LTP
1.00
 - S_TKc
0.28
 --
S 222 SGQLIDSMANSFVGTRSYMSP - 17192257
HTP
1.00
 - S_TKc
0.28
 --
T 286 GCQVEGDAAETPPRPRTPGRP CDK_group 11684694
LTP
0.12
 MOD_CDK_SPxK_1
 - S_TKc
0.74
 --
T 286 GCQVEGDAAETPPRPRTPGRP CDK1 11684694
LTP
0.12
 MOD_CDK_SPxK_1
 - S_TKc
0.74
 --
T 286 GCQVEGDAAETPPRPRTPGRP - 12609978
LTP
0.12
 MOD_CDK_SPxK_1
 - S_TKc
0.74
 --
T 292 DAAETPPRPRTPGRPLSSYGM MAPK1 10567369
LTP
0.12
 MOD_ProDKin_1
 - S_TKc
0.78
 --
T 292 DAAETPPRPRTPGRPLSSYGM - 9351825
LTP
0.12
 MOD_ProDKin_1
 - S_TKc
0.78
 --
S 298 PRPRTPGRPLSSYGMDSRPPM MAP2K_group 7873542
LTP
0.74
 - S_TKc
0.69
 --
S 298 PRPRTPGRPLSSYGMDSRPPM PAK1 12876277
LTP
0.74
 - S_TKc
0.69
 --
S 298 PRPRTPGRPLSSYGMDSRPPM PAK1 9351825
LTP
0.74
 - S_TKc
0.69
 --
S 298 PRPRTPGRPLSSYGMDSRPPM PAK1 16129686
LTP
0.74
 - S_TKc
0.69
 --
S 298 PRPRTPGRPLSSYGMDSRPPM PAK1 14993270
LTP
0.74
 - S_TKc
0.69
 --
T 386 CSTIGLNQPSTPTHAAGV    MAPK1 10567369
LTP
0.71
 MOD_ProDKin_1
 - -
0.48
 --

Valid HTML 4.01 Transitional