Substrate: MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1))
Seq-ID: P29678 [Oryctolagus cuniculus]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
protein tyrosine kinase activity,
protein binding
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 218 DFGVSGQLIDSMANSFVGTRS RAF1 8157000
LTP
1.00
 - S_TKc
0.20
 3EQC 29.51%
S 222 SGQLIDSMANSFVGTRSYMSP RAF1 8157000
LTP
1.00
 - S_TKc
0.28
 --

Substrate: MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1))
Seq-ID: P31938 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
MINT-16657   BRAF_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
MAP kinase kinase activity,
ATP binding,
protein tyrosine kinase activity,
receptor signaling protein tyrosine phosphatase activity		 placenta blood vessel development,
positive regulation of cell differentiation,
cell motility,
keratinocyte differentiation,
labyrinthine layer development,
activation of MAPK activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 218 DFGVSGQLIDSMANSFVGTRS - 15665076
LTP
1.00
 - S_TKc
0.19
 3EQC 29.51%
S 218 DFGVSGQLIDSMANSFVGTRS - 14963034
LTP
1.00
 - S_TKc
0.19
 3EQC 29.51%
S 218 DFGVSGQLIDSMANSFVGTRS - 12181353
LTP
1.00
 - S_TKc
0.19
 3EQC 29.51%
S 218 DFGVSGQLIDSMANSFVGTRS - 12032835
LTP
1.00
 - S_TKc
0.19
 3EQC 29.51%
S 218 DFGVSGQLIDSMANSFVGTRS - 12604616
LTP
1.00
 - S_TKc
0.19
 3EQC 29.51%
S 222 SGQLIDSMANSFVGTRSYMSP - 15665076
LTP
1.00
 - S_TKc
0.28
 --
S 222 SGQLIDSMANSFVGTRSYMSP - 14963034
LTP
1.00
 - S_TKc
0.28
 --
S 222 SGQLIDSMANSFVGTRSYMSP - 12181353
LTP
1.00
 - S_TKc
0.28
 --
S 222 SGQLIDSMANSFVGTRSYMSP - 12032835
LTP
1.00
 - S_TKc
0.28
 --
S 222 SGQLIDSMANSFVGTRSYMSP - 12604616
LTP
1.00
 - S_TKc
0.28
 --
T 286 GCHVEGDAAETPPRPRTPGRP CDK5 11684694
LTP
0.12
 MOD_CDK_SPxK_1
 - S_TKc
0.70
 --
T 286 GCHVEGDAAETPPRPRTPGRP CDK5 15665076
LTP
0.12
 MOD_CDK_SPxK_1
 - S_TKc
0.70
 --
T 292 DAAETPPRPRTPGRPLSSYGM MAP3K1 8019005
LTP
0.12
 - S_TKc
0.78
 --

Substrate: MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1))
Seq-ID: Q02750 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16002   KSR1_MOUSE
MINT-3391583   M3K1_HUMAN
MINT-4300484   MK01_HUMAN
MINT-7014370   RAF1_HUMAN
MINT-7014390   MK03_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
MAP kinase kinase activity,
ATP binding,
protein tyrosine kinase activity		 cytosol senescence,
negative regulation of cell proliferation,
cell cycle arrest,
chemotaxis,
Ras protein signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 23 PAPDGSAVNGTSSAETNLEAL MAP2K_group 7873542
LTP
0.17
 - COIL
0.69
 --
S 24 APDGSAVNGTSSAETNLEALQ MAP2K_group 7873542
LTP
0.44
 - COIL
0.65
 --
S 25 PDGSAVNGTSSAETNLEALQK MAP2K_group 7873542
LTP
0.02
 - COIL
0.63
 --
S 212 GEIKLCDFGVSGQLIDSMANS - 12506122
LTP
1.00
 - S_TKc
0.16
 3EQC 3.28%
S 218 DFGVSGQLIDSMANSFVGTRS MAP2K_group 7873542
LTP
1.00
 - S_TKc
0.20
 3EQC 29.51%
S 218 DFGVSGQLIDSMANSFVGTRS - 7936666
LTP
1.00
 - S_TKc
0.20
 3EQC 29.51%
S 218 DFGVSGQLIDSMANSFVGTRS MAP3K_group 7624324
LTP
1.00
 - S_TKc
0.20
 3EQC 29.51%
S 218 DFGVSGQLIDSMANSFVGTRS MAP3K8 15466476
LTP
1.00
 - S_TKc
0.20
 3EQC 29.51%
S 218 DFGVSGQLIDSMANSFVGTRS MAP3K_group 15466476
LTP
1.00
 - S_TKc
0.20
 3EQC 29.51%
S 218 DFGVSGQLIDSMANSFVGTRS RAF1 8131746
LTP
1.00
 - S_TKc
0.20
 3EQC 29.51%
S 222 SGQLIDSMANSFVGTRSYMSP PDK-1 15175348
LTP
1.00
 - S_TKc
0.28
 --
S 222 SGQLIDSMANSFVGTRSYMSP MAP3K_group 7624324
LTP
1.00
 - S_TKc
0.28
 --
S 222 SGQLIDSMANSFVGTRSYMSP - 8039496
LTP
1.00
 - S_TKc
0.28
 --
S 222 SGQLIDSMANSFVGTRSYMSP MAP3K8 15466476
LTP
1.00
 - S_TKc
0.28
 --
S 222 SGQLIDSMANSFVGTRSYMSP MAP3K_group 15466476
LTP
1.00
 - S_TKc
0.28
 --
S 222 SGQLIDSMANSFVGTRSYMSP RAF1 8131746
LTP
1.00
 - S_TKc
0.28
 --
S 222 SGQLIDSMANSFVGTRSYMSP - 17192257
HTP
1.00
 - S_TKc
0.28
 --
T 286 GCQVEGDAAETPPRPRTPGRP CDK_group 11684694
LTP
0.12
 MOD_CDK_SPxK_1
 - S_TKc
0.74
 --
T 286 GCQVEGDAAETPPRPRTPGRP CDK1 11684694
LTP
0.12
 MOD_CDK_SPxK_1
 - S_TKc
0.74
 --
T 286 GCQVEGDAAETPPRPRTPGRP - 12609978
LTP
0.12
 MOD_CDK_SPxK_1
 - S_TKc
0.74
 --
T 292 DAAETPPRPRTPGRPLSSYGM MAPK1 10567369
LTP
0.12
 MOD_ProDKin_1
 - S_TKc
0.78
 --
T 292 DAAETPPRPRTPGRPLSSYGM - 9351825
LTP
0.12
 MOD_ProDKin_1
 - S_TKc
0.78
 --
S 298 PRPRTPGRPLSSYGMDSRPPM MAP2K_group 7873542
LTP
0.74
 - S_TKc
0.69
 --
S 298 PRPRTPGRPLSSYGMDSRPPM PAK1 12876277
LTP
0.74
 - S_TKc
0.69
 --
S 298 PRPRTPGRPLSSYGMDSRPPM PAK1 9351825
LTP
0.74
 - S_TKc
0.69
 --
S 298 PRPRTPGRPLSSYGMDSRPPM PAK1 16129686
LTP
0.74
 - S_TKc
0.69
 --
S 298 PRPRTPGRPLSSYGMDSRPPM PAK1 14993270
LTP
0.74
 - S_TKc
0.69
 --
T 386 CSTIGLNQPSTPTHAAGV    MAPK1 10567369
LTP
0.71
 MOD_ProDKin_1
 - -
0.48
 --

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