Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q13480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-58395   GRB2_HUMAN
MINT-58403   GRAP2_HUMAN
MINT-58404   MET_HUMAN
MINT-68564   BMX_HUMAN
MINT-1893011   P85A_HUMAN
MINT-6169406   PTN11_HUMAN
MINT-6169502   PAXI_HUMAN
MINT-7971128   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity cytosol epidermal growth factor receptor signaling pathway,
insulin receptor signaling pathway,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 242 MNGFFQQQMIYDSPPSRAPSA INSR 10978177
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2		 -
0.65
 - low
Y 259 APSASVDSSLYNLPRSYSHDV - 12522270
HTP
0.15
 CRKL SH2;
CRK SH2		 -
0.59
 - low
S 266 SSLYNLPRSYSHDVLPKVSPS - 12522270
HTP
0.19
 - -
0.58
 - low
Y 285 PSSTEADGELYVFNTPSGTSS - 10978177
LTP
0.93
 - -
0.71
 - low
Y 285 PSSTEADGELYVFNTPSGTSS EGFR 9890893
LTP
0.93
 - -
0.71
 - low
Y 285 PSSTEADGELYVFNTPSGTSS Met 10734310
LTP
0.93
 - -
0.71
 - low
Y 307 ETQMRHVSISYDIPPTPGNTY Met 10734310
LTP
0.12
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2		 -
0.70
 - low
Y 307 ETQMRHVSISYDIPPTPGNTY EGFR 10734310
LTP
0.12
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2		 -
0.70
 - low
Y 317 YDIPPTPGNTYQIPRTFPEGT - 16497976
HTP
0.24
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
RASA_group SH2		 -
0.74
 - low
Y 373 PRTASDTDSSYCIPTAGMSPS INSR 10978177
LTP
0.08
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.66
 - low
Y 373 PRTASDTDSSYCIPTAGMSPS EGFR 9890893
LTP
0.08
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.66
 - low
Y 373 PRTASDTDSSYCIPTAGMSPS - 10753869
LTP
0.08
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.66
 - low
Y 373 PRTASDTDSSYCIPTAGMSPS Met 10734310
LTP
0.08
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.66
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR EGFR 9890893
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR - 10753869
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR Met 10734310
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR - 18083107
HTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low
Y 447 SVSSEELDENYVPMNPNSPPR INSR 10978177
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2		 -
0.83
 - low
Y 447 SVSSEELDENYVPMNPNSPPR EGFR 9890893
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2		 -
0.83
 - low
Y 447 SVSSEELDENYVPMNPNSPPR Met 10734310
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2		 -
0.83
 - low
Y 472 SFTEPIQEANYVPMTPGTFDF INSR 10978177
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2		 -
0.54
 - low
Y 472 SFTEPIQEANYVPMTPGTFDF EGFR 9890893
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2		 -
0.54
 - low
Y 472 SFTEPIQEANYVPMTPGTFDF Met 10734310
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2		 -
0.54
 - low
T 476 PIQEANYVPMTPGTFDFSSFG MAPK1 15379552
LTP
0.18
 MOD_ProDKin_1
 - -
0.50
 - low
Y 589 SSDSHDSEENYVPMNPNLSSE INSR 10978177
LTP
1.00
 PIK3R1 SH2;
PTPN11 SH2		 -
0.89
 - low
Y 589 SSDSHDSEENYVPMNPNLSSE EGFR 9890893
LTP
1.00
 PIK3R1 SH2;
PTPN11 SH2		 -
0.89
 - low
Y 589 SSDSHDSEENYVPMNPNLSSE Met 10734310
LTP
1.00
 PIK3R1 SH2;
PTPN11 SH2		 -
0.89
 - low
Y 627 IKPKGDKQVEYLDLDLDSGKS INSR 10978177
LTP
1.00
 PTPN11 SH2 -
0.72
 - low
Y 627 IKPKGDKQVEYLDLDLDSGKS EGFR 9890893
LTP
1.00
 PTPN11 SH2 -
0.72
 - low
Y 627 IKPKGDKQVEYLDLDLDSGKS Met 10734310
LTP
1.00
 PTPN11 SH2 -
0.72
 - low
Y 627 IKPKGDKQVEYLDLDLDSGKS - 18083107
HTP
1.00
 PTPN11 SH2 -
0.72
 - low
Y 659 GSSVADERVDYVVVDQQKTLA - 10978177
LTP
1.00
 PTPN11 SH2 -
0.61
 - low
Y 659 GSSVADERVDYVVVDQQKTLA EGFR 9890893
LTP
1.00
 PTPN11 SH2 -
0.61
 - low
Y 659 GSSVADERVDYVVVDQQKTLA Met 10734310
LTP
1.00
 PTPN11 SH2 -
0.61
 - low
Y 659 GSSVADERVDYVVVDQQKTLA - 18083107
HTP
1.00
 PTPN11 SH2 -
0.61
 - low
Y 659 GSSVADERVDYVVVDQQKTLA - 18669648
HTP
1.00
 PTPN11 SH2 -
0.61
 - low

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