Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q13480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-58395   GRB2_HUMAN
MINT-58403   GRAP2_HUMAN
MINT-58404   MET_HUMAN
MINT-68564   BMX_HUMAN
MINT-1893011   P85A_HUMAN
MINT-6169406   PTN11_HUMAN
MINT-6169502   PAXI_HUMAN
MINT-7971128   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity cytosol epidermal growth factor receptor signaling pathway,
insulin receptor signaling pathway,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 242 MNGFFQQQMIYDSPPSRAPSA INSR 10978177
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2		 -
0.65
 - low
Y 259 APSASVDSSLYNLPRSYSHDV - 12522270
HTP
0.15
 CRKL SH2;
CRK SH2		 -
0.59
 - low
S 266 SSLYNLPRSYSHDVLPKVSPS - 12522270
HTP
0.19
 - -
0.58
 - low
Y 285 PSSTEADGELYVFNTPSGTSS - 10978177
LTP
0.93
 - -
0.71
 - low
Y 285 PSSTEADGELYVFNTPSGTSS EGFR 9890893
LTP
0.93
 - -
0.71
 - low
Y 285 PSSTEADGELYVFNTPSGTSS Met 10734310
LTP
0.93
 - -
0.71
 - low
Y 307 ETQMRHVSISYDIPPTPGNTY Met 10734310
LTP
0.12
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2		 -
0.70
 - low
Y 307 ETQMRHVSISYDIPPTPGNTY EGFR 10734310
LTP
0.12
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2		 -
0.70
 - low
Y 317 YDIPPTPGNTYQIPRTFPEGT - 16497976
HTP
0.24
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
RASA_group SH2		 -
0.74
 - low
Y 373 PRTASDTDSSYCIPTAGMSPS INSR 10978177
LTP
0.08
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.66
 - low
Y 373 PRTASDTDSSYCIPTAGMSPS EGFR 9890893
LTP
0.08
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.66
 - low
Y 373 PRTASDTDSSYCIPTAGMSPS - 10753869
LTP
0.08
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.66
 - low
Y 373 PRTASDTDSSYCIPTAGMSPS Met 10734310
LTP
0.08
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.66
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR EGFR 9890893
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR - 10753869
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR Met 10734310
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR - 18083107
HTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low
Y 447 SVSSEELDENYVPMNPNSPPR INSR 10978177
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2		 -
0.83
 - low
Y 447 SVSSEELDENYVPMNPNSPPR EGFR 9890893
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2		 -
0.83
 - low
Y 447 SVSSEELDENYVPMNPNSPPR Met 10734310
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2		 -
0.83
 - low
Y 472 SFTEPIQEANYVPMTPGTFDF INSR 10978177
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2		 -
0.54
 - low
Y 472 SFTEPIQEANYVPMTPGTFDF EGFR 9890893
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2		 -
0.54
 - low
Y 472 SFTEPIQEANYVPMTPGTFDF Met 10734310
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2		 -
0.54
 - low
T 476 PIQEANYVPMTPGTFDFSSFG MAPK1 15379552
LTP
0.18
 MOD_ProDKin_1
 - -
0.50
 - low
Y 589 SSDSHDSEENYVPMNPNLSSE INSR 10978177
LTP
1.00
 PIK3R1 SH2;
PTPN11 SH2		 -
0.89
 - low
Y 589 SSDSHDSEENYVPMNPNLSSE EGFR 9890893
LTP
1.00
 PIK3R1 SH2;
PTPN11 SH2		 -
0.89
 - low
Y 589 SSDSHDSEENYVPMNPNLSSE Met 10734310
LTP
1.00
 PIK3R1 SH2;
PTPN11 SH2		 -
0.89
 - low
Y 627 IKPKGDKQVEYLDLDLDSGKS INSR 10978177
LTP
1.00
 PTPN11 SH2 -
0.72
 - low
Y 627 IKPKGDKQVEYLDLDLDSGKS EGFR 9890893
LTP
1.00
 PTPN11 SH2 -
0.72
 - low
Y 627 IKPKGDKQVEYLDLDLDSGKS Met 10734310
LTP
1.00
 PTPN11 SH2 -
0.72
 - low
Y 627 IKPKGDKQVEYLDLDLDSGKS - 18083107
HTP
1.00
 PTPN11 SH2 -
0.72
 - low
Y 659 GSSVADERVDYVVVDQQKTLA - 10978177
LTP
1.00
 PTPN11 SH2 -
0.61
 - low
Y 659 GSSVADERVDYVVVDQQKTLA EGFR 9890893
LTP
1.00
 PTPN11 SH2 -
0.61
 - low
Y 659 GSSVADERVDYVVVDQQKTLA Met 10734310
LTP
1.00
 PTPN11 SH2 -
0.61
 - low
Y 659 GSSVADERVDYVVVDQQKTLA - 18083107
HTP
1.00
 PTPN11 SH2 -
0.61
 - low
Y 659 GSSVADERVDYVVVDQQKTLA - 18669648
HTP
1.00
 PTPN11 SH2 -
0.61
 - low

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q9QYY0 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-58371   MET_MOUSE
MINT-58374   MET_HUMAN
MINT-58378   PLCG1_MOUSE
MINT-58379   SHC1_MOUSE
MINT-58385   SHIP2_HUMAN
MINT-58390   CRKL_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
signal transducer activity,
protein binding		 cytoplasm epidermis development,
interleukin-6-mediated signaling pathway,
positive regulation of MAPKKK cascade,
regulation of cell migration,
response to oxidative stress,
activation of JUN kinase activity,
epidermal growth factor receptor signaling pathway,
heart development,
labyrinthine layer development,
platelet-derived growth factor receptor signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 285 PSSTEADGELYTFNTPSGTAG Met 10734310
LTP
0.93
 - -
0.77
 - medium
Y 285 PSSTEADGELYTFNTPSGTAG EGFR 10734310
LTP
0.93
 - -
0.77
 - medium
Y 307 ETQMRHVSISYDIPPTPGNTY Met 10734310
LTP
0.12
 - -
0.71
 - medium
Y 307 ETQMRHVSISYDIPPTPGNTY EGFR 10734310
LTP
0.12
 - -
0.71
 - medium
Y 373 PRTASDTDSSYCIPPPAGMTP Met 10734310
LTP
0.08
 - -
0.75
 - medium
Y 373 PRTASDTDSSYCIPPPAGMTP EGFR 10734310
LTP
0.08
 - -
0.75
 - medium
Y 407 LRKDASSQDCYDIPRTFPSDR Met 10734310
LTP
1.00
 - -
0.66
 - medium
Y 407 LRKDASSQDCYDIPRTFPSDR EGFR 10734310
LTP
1.00
 - -
0.66
 - medium
Y 448 GVSGEELDENYVPMNPNSPPR Met 10734310
LTP
1.00
 - -
0.87
 - medium
Y 448 GVSGEELDENYVPMNPNSPPR EGFR 10734310
LTP
1.00
 - -
0.87
 - medium
Y 473 SFTEPIQEPNYVPMTPGTFDF Met 10734310
LTP
1.00
 - -
0.61
 - medium
Y 473 SFTEPIQEPNYVPMTPGTFDF EGFR 10734310
LTP
1.00
 - -
0.61
 - medium
Y 473 SFTEPIQEPNYVPMTPGTFDF - 11896055
LTP
1.00
 - -
0.61
 - medium
T 477 PIQEPNYVPMTPGTFDFSSFG - 11896055
LTP
0.17
 - -
0.56
 - medium
T 504 AHMGFRSSPKTPPRRPVPVAD - 17242355
HTP
1.00
 - -
0.81
 - medium
Y 590 SSDSHDSEENYVPMNPNLSGE Met 10734310
LTP
1.00
 - -
0.90
 - medium
Y 590 SSDSHDSEENYVPMNPNLSGE EGFR 10734310
LTP
1.00
 - -
0.90
 - medium
Y 628 NKPKGDKQVEYLDLDLDSGKS Met 10734310
LTP
1.00
 - -
0.78
 - medium
Y 628 NKPKGDKQVEYLDLDLDSGKS EGFR 10734310
LTP
1.00
 - -
0.78
 - medium
Y 660 GSSMADERVDYVVVDQQKTLA Met 10734310
LTP
1.00
 - -
0.68
 - medium
Y 660 GSSMADERVDYVVVDQQKTLA EGFR 10734310
LTP
1.00
 - -
0.68
 - medium

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