a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

Substrate:	SYK (Spleen tyrosine kinase )
Seq-ID:	P43405 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-56730   LCK_HUMAN MINT-56732   P85A_HUMAN MINT-56739   FGR_HUMAN MINT-56749   P85B_HUMAN MINT-74763   EGFR_HUMAN MINT-74769   ERBB2_HUMAN MINT-74775   ERBB3_HUMAN MINT-74776   ERBB4_HUMAN MINT-6538977   CBL_HUMAN MINT-6621148   BLNK_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process non-membrane spanning protein tyrosine kinase activity, ATP binding, integrin binding cytoplasm, T cell receptor complex protein complex assembly, organ morphogenesis, integrin-mediated signaling pathway, neutrophil chemotaxis, interspecies interaction between organisms, cell proliferation, leukocyte cell-cell adhesion
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	323	RQESTVSFNPYEPELAPWAAD	-	16497976	HTP	0.80		CBLB SH2; CBL PTB; PIK3R1 SH2	-	0.51	-	-
Y	323	RQESTVSFNPYEPELAPWAAD	-	18083107	HTP	0.80		CBLB SH2; CBL PTB; PIK3R1 SH2	-	0.51	-	-
Y	525	LSKALRADENYYKAQTHGKWP	SYK	8657103	LTP	1.00		CBL PTB; Lck SH2	TyrKc	0.19	1XBA	41.92%
Y	526	SKALRADENYYKAQTHGKWPV	SYK	8657103	LTP	1.00		CBL PTB; Lck SH2	TyrKc	0.17	1XBA	30.57%
Y	526	SKALRADENYYKAQTHGKWPV	-	18083107	HTP	1.00		CBL PTB; Lck SH2	TyrKc	0.17	1XBA	30.57%

Substrate:	ZAP70 (Cytoplasmic tyrosine kinase)
Seq-ID:	P43403 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-59476   LCK_HUMAN MINT-60980   SHC1_HUMAN MINT-74806   ERBB3_HUMAN MINT-74807   EGFR_HUMAN MINT-3374106   HS90A_HUMAN MINT-3382488   LAT_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process non-membrane spanning protein tyrosine kinase activity, ATP binding cytosol, T cell receptor complex positive thymic T cell selection, immune response, intracellular protein kinase cascade
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	292	RRIDTLNSDGYTPEPARITSP	Lck	8756661	LTP	1.00		CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-
Y	292	RRIDTLNSDGYTPEPARITSP	ZAP70	8756661	LTP	1.00		CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-
Y	292	RRIDTLNSDGYTPEPARITSP	Lck	7961936	LTP	1.00		CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-
Y	292	RRIDTLNSDGYTPEPARITSP	ZAP70	7961936	LTP	1.00		CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-
Y	292	RRIDTLNSDGYTPEPARITSP	-	15144186	HTP	1.00		CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-
Y	292	RRIDTLNSDGYTPEPARITSP	-	15592455	HTP	1.00		CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-
Y	292	RRIDTLNSDGYTPEPARITSP	-	16094384	HTP	1.00		CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-
Y	292	RRIDTLNSDGYTPEPARITSP	-	15659558	HTP	1.00		CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-
Y	292	RRIDTLNSDGYTPEPARITSP	-	17192257	HTP	1.00		CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-

Substrate:	Src (Proto-oncogene tyrosine-protein kinase Src)
Seq-ID:	P12931 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-14765   DDR2_HUMAN MINT-15459   CAV1_HUMAN MINT-46002   CTNB1_MOUSE MINT-50376   RASH_HUMAN MINT-62340   KPCD_HUMAN MINT-62342   CDCP1_HUMAN MINT-65953   DYN1_HUMAN MINT-65954   DYN2_HUMAN MINT-68512   PDC6I_HUMAN MINT-74753   ERBB3_HUMAN MINT-2792760   PAK2_HUMAN MINT-2793013   ADA15_HUMAN MINT-2840132   TLR3_HUMAN MINT-3381308   FAK1_HUMAN MINT-3381360   FYN_HUMAN MINT-4051815   ADRB2_HUMAN MINT-4961196   AFAD_HUMAN MINT-4980122   SNIP_MOUSE MINT-5210599   SNIP_HUMAN MINT-6539730   CBL_HUMAN MINT-6771405   FAK1_MOUSE MINT-6794909   ACTS_HUMAN MINT-6795322   ACTN1_HUMAN MINT-6795447   PTN1_HUMAN MINT-7035260   HNRPK_HUMAN MINT-7040283   CBLB_HUMAN MINT-7104422   BCAR1_HUMAN MINT-7145938   RL10_HUMAN MINT-7244986   ASAP1_HUMAN MINT-7244998   FANCA_HUMAN MINT-7245022   PHAR2_HUMAN MINT-7245034   ABL1_HUMAN MINT-7245058   DLGP4_HUMAN MINT-7245070   SNX17_HUMAN MINT-7245106   RTN4_HUMAN MINT-7245118   ASAP2_HUMAN MINT-7245142   E41L3_HUMAN MINT-7245154   ICAL_HUMAN MINT-7245214   FCG2B_HUMAN MINT-7245226   FCG2C_HUMAN MINT-7245334   SHAN2_HUMAN MINT-7245346   SHRM2_HUMAN MINT-7245358   DNLI3_HUMAN MINT-7245370   EIF3D_HUMAN MINT-7245406   HCN2_HUMAN MINT-7245490   CKAP5_HUMAN MINT-7245502   M4K1_HUMAN MINT-7245538   RPP38_HUMAN MINT-7245562   SP1_HUMAN MINT-7245574   DOCK1_HUMAN MINT-7245586   RLGPB_HUMAN MINT-7245598   ABL2_HUMAN MINT-7245610   CELR2_HUMAN MINT-7245622   SOS1_HUMAN MINT-7245634   AKAP6_HUMAN MINT-7245670   DPOD1_HUMAN MINT-7245682   DAG1_HUMAN MINT-7245694   SNX3_HUMAN MINT-7245730   KI67_HUMAN MINT-7245742   CD97_HUMAN MINT-7245754   RPGF1_HUMAN MINT-7245778   ACAP1_HUMAN MINT-7245790   PRIC3_HUMAN MINT-7245814   AKAP2_HUMAN MINT-7245826   RRAS_HUMAN MINT-7296136   P85A_HUMAN MINT-7296149   ACTB_HUMAN MINT-7306598   LCP2_HUMAN MINT-7552515   PTPRA_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH3/SH2 adaptor activity, non-membrane spanning protein tyrosine kinase activity, ATP binding, integrin binding, SH2 domain binding caveola, cytosol protein amino acid phosphorylation, regulation of bone resorption, signal complex assembly, regulation of vascular permeability, response to interleukin-1, interspecies interaction between organisms, Ras protein signal transduction, positive regulation of integrin activation, intracellular protein kinase cascade
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	419	GLARLIEDNEYTARQGAKFPI	-	6273838	LTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	-	11278940	LTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	SRC	7578094	LTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	SRC	11804588	LTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	SRC	15489898	LTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	-	17081983	HTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	-	17192257	HTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%