List of substrates found:

FCER1G  MS4A2  Bcr  P130Cas 


Substrate: FCER1G (FceRI gamma)
Seq-ID: P30273 [Homo sapiens]
Download:fasta csv
Interaction Network(s):
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
IgE binding,
transmembrane receptor activity		 integral to plasma membrane cell surface receptor linked signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 65 ITSYEKSDGVYTGLSTRNQET - 18088087
HTP
1.00
 FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.29
 - low
Y 65 ITSYEKSDGVYTGLSTRNQET - 18083107
HTP
1.00
 FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.29
 - low
Y 76 TGLSTRNQETYETLKHEKPPQ - 18088087
HTP
1.00
 FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.54
 - low
Y 76 TGLSTRNQETYETLKHEKPPQ - 18083107
HTP
1.00
 FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.54
 - low

Substrate: MS4A2 (calcium channel activity)
Seq-ID: Q01362 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium channel activity integral to plasma membrane humoral immune response,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 219 KGNKVPEDRVYEELNIYSATY - 15339926
LTP
0.12
 FES SH2;
Lyn SH2;
SHC1 SH2;
SYK SH2		 -
0.21
 - medium

Substrate: Bcr (Breakpoint cluster region protein)
Seq-ID: P11274 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-69534   AT2B1_HUMAN
MINT-69536   CLH1_HUMAN
MINT-69537   CFTR_HUMAN
MINT-69540   ZO2_HUMAN
MINT-69542   RGS12_HUMAN
MINT-4961172   AFAD_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Rho guanyl-nucleotide exchange factor activity,
protein serine/threonine kinase activity,
ATP binding,
GTPase activator activity		 intracellular protein amino acid phosphorylation,
signal transduction,
regulation of Rho protein signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 177 QPGADAEKPFYVNVEFHHERG Fes 8955135
LTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium
Y 177 QPGADAEKPFYVNVEFHHERG Fes 10405761
LTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium
Y 177 QPGADAEKPFYVNVEFHHERG - 12522270
HTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium
Y 177 QPGADAEKPFYVNVEFHHERG - 9178913
LTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium
Y 177 QPGADAEKPFYVNVEFHHERG - 12124177
LTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium
Y 177 QPGADAEKPFYVNVEFHHERG - 9407116
LTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium
Y 177 QPGADAEKPFYVNVEFHHERG Abl 16912036
LTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium
Y 177 QPGADAEKPFYVNVEFHHERG HCK 16912036
LTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium
Y 177 QPGADAEKPFYVNVEFHHERG - 18083107
HTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium

Substrate: P130Cas (Adaptor molecule. Contain 15 YxxP motifs. )
Seq-ID: P56945 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-74936   PTN12_HUMAN
MINT-74938   FAK1_HUMAN
MINT-3974941   1433S_HUMAN
MINT-6174734   ACTB_HUMAN
MINT-6763936   CRK_HUMAN
MINT-6793484   PTN1_HUMAN
MINT-7104353   CDC42_HUMAN
MINT-7104422   SRC_HUMAN
MINT-7104436   ACK1_HUMAN
MINT-7247002   FYN_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
protein kinase binding,
protein phosphatase binding,
signal transducer activity		 focal adhesion,
membrane fraction,
cytosol,
ruffle		 regulation of cell growth,
B cell receptor signaling pathway,
cell division,
positive regulation of cell migration,
nerve growth factor receptor signaling pathway,
cell migration,
integrin-mediated signaling pathway,
epidermal growth factor receptor signaling pathway,
actin filament organization,
regulation of apoptosis,
platelet-derived growth factor receptor signaling pathway,
T cell receptor signaling pathway,
cell adhesion,
insulin receptor signaling pathway,
cell proliferation,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 664 ENSEGGWMEDYDYVHLQGKEE - 8621540
LTP
1.00
 FES SH2;
Fyn SH2;
Lck SH2;
Src SH2		 -
0.49
 - medium
Y 664 ENSEGGWMEDYDYVHLQGKEE - 11604500
LTP
1.00
 FES SH2;
Fyn SH2;
Lck SH2;
Src SH2		 -
0.49
 - medium

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