List of substrates found:

CD28  CSFR-1  Shc  LAT 


Substrate: CD28 (Involved in T cell activation)
Seq-ID: P10747 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding,
SH3/SH2 adaptor activity,
coreceptor activity		 external side of plasma membrane,
cytosol,
integral to plasma membrane		 regulatory T cell differentiation,
humoral immune response,
positive regulation of anti-apoptosis,
regulation of defense response to virus by virus,
positive regulation of interleukin-2 biosynthetic process,
positive regulation of viral genome replication,
cell surface receptor linked signaling pathway,
cytokine biosynthetic process,
positive regulation of mitosis,
positive regulation of T cell proliferation,
positive regulation of translation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 191 SKRSRLLHSDYMNMTPRRPGP Lck 8992971
LTP
0.95
 GRAP2 SH2;
GRB2 SH2;
ITK SH2;
PIK3R1 SH2		 -
0.44
 - medium
Y 191 SKRSRLLHSDYMNMTPRRPGP ITK 8992971
LTP
0.95
 GRAP2 SH2;
GRB2 SH2;
ITK SH2;
PIK3R1 SH2		 -
0.44
 - medium
Y 191 SKRSRLLHSDYMNMTPRRPGP - 16094384
HTP
0.95
 GRAP2 SH2;
GRB2 SH2;
ITK SH2;
PIK3R1 SH2		 -
0.44
 - medium

Substrate: CSFR-1 (Macrophage colony stimulating factor I receptor)
Seq-ID: P07333 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
macrophage colony-stimulating factor receptor activity,
protein homodimerization activity,
ATP binding,
cytokine binding		 receptor complex,
integral to plasma membrane		 protein amino acid phosphorylation,
transmembrane receptor protein tyrosine kinase signaling pathway,
multicellular organismal development,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 699 PGQDPEGGVDYKNIHLEKKYV - N.N.
LTP
1.00
 GRAP2 SH2;
GRB2 SH2		 TyrKc
0.45
 - low

Substrate: Shc ( Adaptor molecule)
Seq-ID: P29353 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13959   DDR2_HUMAN
MINT-14688   GAB2_HUMAN
MINT-15243   LYN_HUMAN
MINT-15425   FYN_HUMAN
MINT-15946   FCGR1_HUMAN
MINT-16179   SHIP1_HUMAN
MINT-16513   LCP2_HUMAN
MINT-17269   SRC_CHICK
MINT-17501   P85A_HUMAN
MINT-49636   CADH5_HUMAN
MINT-49637   VGFR2_HUMAN
MINT-49660   A4_HUMAN
MINT-60978   CBL_HUMAN
MINT-60980   ZAP70_HUMAN
MINT-60981   RET_HUMAN
MINT-61536   ERBB4_HUMAN
MINT-61537   GRB2_HUMAN
MINT-74732   EGFR_HUMAN
MINT-74737   ERBB2_HUMAN
MINT-74738   ERBB3_HUMAN
MINT-1782423   SOS1_HUMAN
MINT-2738306   JAK2_MOUSE
MINT-7714840   IQGA1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor binding,
insulin-like growth factor receptor binding,
insulin receptor binding,
phospholipid binding,
transmembrane receptor protein tyrosine kinase adaptor protein activity		 mitochondrial matrix,
Shc-EGFR complex,
cytosol		 positive regulation of DNA replication,
positive regulation of cell proliferation,
regulation of growth,
regulation of epidermal growth factor receptor activity,
epidermal growth factor receptor signaling pathway,
activation of MAPK activity,
Ras protein signal transduction,
insulin receptor signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 349 EEEEEPPDHQYYNDFPGKEPP - 11075717
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.86
 --
Y 349 EEEEEPPDHQYYNDFPGKEPP - 9121430
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.86
 --
Y 349 EEEEEPPDHQYYNDFPGKEPP SYK 9710204
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.86
 --
Y 349 EEEEEPPDHQYYNDFPGKEPP ZAP70 9710204
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.86
 --
Y 349 EEEEEPPDHQYYNDFPGKEPP - 10891441
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.86
 --
Y 349 EEEEEPPDHQYYNDFPGKEPP - 11687594
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.86
 --
Y 349 EEEEEPPDHQYYNDFPGKEPP - 15592455
HTP
1.00
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.86
 --
Y 349 EEEEEPPDHQYYNDFPGKEPP FLT4 9927207
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.86
 --
Y 427 PGRELFDDPSYVNVQNLDKAR - 11075717
LTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --
Y 427 PGRELFDDPSYVNVQNLDKAR SYK 9710204
LTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --
Y 427 PGRELFDDPSYVNVQNLDKAR ZAP70 9710204
LTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --
Y 427 PGRELFDDPSYVNVQNLDKAR - 8610109
LTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --
Y 427 PGRELFDDPSYVNVQNLDKAR - 9741627
LTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --
Y 427 PGRELFDDPSYVNVQNLDKAR - 12522270
HTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --
Y 427 PGRELFDDPSYVNVQNLDKAR - 15592455
HTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --
Y 427 PGRELFDDPSYVNVQNLDKAR FLT4 9927207
LTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --
Y 427 PGRELFDDPSYVNVQNLDKAR - 18083107
HTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --
Y 427 PGRELFDDPSYVNVQNLDKAR - 18669648
HTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --

Substrate: LAT (Adaptor molecule involved in the TCR signal pathway)
Seq-ID: O43561 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-3382436   GRB2_HUMAN
MINT-3382457   SOS1_MOUSE
MINT-3382488   ZAP70_HUMAN
MINT-6794135   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity immunological synapse,
integral to membrane,
membrane raft		 calcium-mediated signaling,
integrin-mediated signaling pathway,
mast cell degranulation,
regulation of T cell activation,
Ras protein signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 220 AEASLDGSREYVNVSQELHPG - 15659558
HTP
1.00
 GRAP2 SH2;
GRB2 SH2;
PIK3R1 SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.71
 - medium

Substrate: LAT (Adaptor molecule involved in the TCR signal pathway)
Seq-ID: O54957 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity,
receptor signaling protein activity		 integral to plasma membrane,
immunological synapse		 calcium-mediated signaling,
integrin-mediated signaling pathway,
gene expression,
cellular defense response,
inflammatory response,
mast cell degranulation,
regulation of T cell activation,
Ras protein signal transduction,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 175 SAFSVESCEDYVNVPESEESA - 10811803
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
VAV_group SH2		 -
0.71
 - low
Y 175 SAFSVESCEDYVNVPESEESA ZAP70 11368773
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
VAV_group SH2		 -
0.71
 - low
Y 195 AEASLDGSREYVNVSPEQQPV - 10811803
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
VAV_group SH2		 -
0.83
 - low
Y 195 AEASLDGSREYVNVSPEQQPV ZAP70 11368773
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
VAV_group SH2		 -
0.83
 - low

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