List of substrates found:

MS4A2  SH3 domain-binding protein 2  CBL E3 ubiquitin protein ligase  Band 3 anion transport protein  Epo-R  FCGR2B  LckBP1  PKC delta 


Substrate: MS4A2 (calcium channel activity)
Seq-ID: Q01362 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium channel activity integral to plasma membrane humoral immune response,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 219 KGNKVPEDRVYEELNIYSATY - 15339926
LTP
0.12
 FES SH2;
Lyn SH2;
SHC1 SH2;
SYK SH2		 -
0.21
 - medium

Substrate: SH3 domain-binding protein 2 (Adaptor molecule)
Seq-ID: Q06649 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 446 DTGEEDSDEDYEKVPLPNSVF - 12709437
LTP
1.00
 Lck SH2;
Lyn SH2;
VAV1 SH2		 -
0.70
 - low

Substrate: CBL E3 ubiquitin protein ligase (Adaptor molecule)
Seq-ID: P22681 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15516   LCK_HUMAN
MINT-15716   CRK_HUMAN
MINT-16022   CD2AP_HUMAN
MINT-16347   LYN_HUMAN
MINT-16846   LCP2_HUMAN
MINT-17062   FCGR1_HUMAN
MINT-17932   NCK1_HUMAN
MINT-50666   FYN_HUMAN
MINT-50717   ABL1_HUMAN
MINT-50722   CRKL_HUMAN
MINT-58331   ITCH_HUMAN
MINT-60970   RET_HUMAN
MINT-60973   EGFR_HUMAN
MINT-60978   SHC1_HUMAN
MINT-68500   P85A_HUMAN
MINT-2837344   PLCG1_BOVIN
MINT-4299918   ASAP1_HUMAN
MINT-6169713   SPY1_HUMAN
MINT-6170244   SH3G2_HUMAN
MINT-6538940   SPY4_HUMAN
MINT-6538977   KSYK_HUMAN
MINT-6539587   MET_HUMAN
MINT-6539601   SPY2_HUMAN
MINT-6539646   VGFR1_HUMAN
MINT-6539679   RON_HUMAN
MINT-6539730   SRC_HUMAN
MINT-7040249   GRB2_HUMAN
MINT-7046364   ITSN1_HUMAN
MINT-7103623   MK08_HUMAN
MINT-7211864   ARHG7_HUMAN
MINT-7214822   FYN_MOUSE
MINT-7218352   SH3K1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
calcium ion binding,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
signal transducer activity,
ubiquitin-protein ligase activity		 cytosol,
nucleus		 epidermal growth factor receptor signaling pathway,
positive regulation of receptor-mediated endocytosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9525940
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA SYK 9525940
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA Yes 9525940
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA - 10934191
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9890970
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA - 12604776
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA - 15922744
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --

Substrate: Band 3 anion transport protein (Anion exchange protein 1)
Seq-ID: P02730 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-58445   CD2A1_HUMAN
MINT-6793324   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
inorganic anion exchanger activity,
protein homodimerization activity,
protein anchor,
ankyrin binding		 cortical cytoskeleton,
basolateral plasma membrane,
integral to plasma membrane		 cellular ion homeostasis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 8    MEELQDDYEDMMEENLEQ Lyn 10942405
LTP
0.00
 Lyn SH2 -
0.80
 --
Y 8    MEELQDDYEDMMEENLEQ SYK 10942405
LTP
0.00
 Lyn SH2 -
0.80
 --
Y 21 MMEENLEQEEYEDPDIPESQM Lyn 10942405
LTP
0.79
 Lyn SH2 -
0.89
 --
Y 21 MMEENLEQEEYEDPDIPESQM SYK 10942405
LTP
0.79
 Lyn SH2 -
0.89
 --

Substrate: Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID: P19235 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-73504   PTN6_HUMAN
MINT-74896   PTN6_MOUSE
MINT-6794748   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
erythropoietin receptor activity extracellular region,
integral to plasma membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 489 GLSDGPYSNPYENSLIPAAEP - 10579919
LTP
1.00
 Lyn SH2 -
0.58
 - low
Y 489 GLSDGPYSNPYENSLIPAAEP - 9573010
LTP
1.00
 Lyn SH2 -
0.58
 - low
Y 504 IPAAEPLPPSYVACS       - 10579919
LTP
0.67
 INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2		 -
0.34
 - low
Y 504 IPAAEPLPPSYVACS       - 7559499
LTP
0.67
 INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2		 -
0.34
 - low
Y 504 IPAAEPLPPSYVACS       - 9573010
LTP
0.67
 INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2		 -
0.34
 - low

Substrate: FCGR2B (protein binding)
Seq-ID: P31994 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-74919   PTN6_HUMAN
MINT-74920   SHIP1_HUMAN
MINT-7245214   SRC_HUMAN
MINT-7247446   FYN_HUMAN
MINT-7251178   NCK1_HUMAN
MINT-7252786   PLCG1_HUMAN
MINT-7254142   CRK_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor activity,
IgG binding		 plasma membrane,
integral to membrane		 immune response,
interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 292 DKVGAENTITYSLLMHPDALE Lyn 8756631
LTP
1.00
 INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2		 -
0.42
 - low
Y 292 DKVGAENTITYSLLMHPDALE BLK 8756631
LTP
1.00
 INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2		 -
0.42
 - low

Substrate: LckBP1 (Hematopoietic cell-specific LYN substrate 1)
Seq-ID: P14317 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-61343   LYN_HUMAN
MINT-67768   SH24A_HUMAN
MINT-7971786   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sequence-specific DNA binding transcription factor activity mitochondrion,
nucleus,
membrane		 intracellular signaling pathway,
positive regulation of cell proliferation,
response to hormone stimulus,
erythrocyte differentiation,
positive regulation of tyrosine phosphorylation of STAT protein,
regulation of transcription, DNA-dependent
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 378 PEPEPEPENDYEDVEEMDRHE - 8578591
LTP
0.18
 Lyn SH2 -
0.98
 - medium
Y 378 PEPEPEPENDYEDVEEMDRHE Lyn 9104825
LTP
0.18
 Lyn SH2 -
0.98
 - medium
Y 378 PEPEPEPENDYEDVEEMDRHE SYK 9104825
LTP
0.18
 Lyn SH2 -
0.98
 - medium
Y 397 HEQEDEPEGDYEEVLEPEDSS - 8578591
LTP
0.80
 Lyn SH2 -
0.95
 - medium
Y 397 HEQEDEPEGDYEEVLEPEDSS Fgr 9183008
LTP
0.80
 Lyn SH2 -
0.95
 - medium
Y 397 HEQEDEPEGDYEEVLEPEDSS Lyn 9104825
LTP
0.80
 Lyn SH2 -
0.95
 - medium
Y 397 HEQEDEPEGDYEEVLEPEDSS SYK 9104825
LTP
0.80
 Lyn SH2 -
0.95
 - medium

Substrate: PKC delta (Protein kinase C, delta)
Seq-ID: Q05655 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-62336   CDCP1_HUMAN
MINT-62340   SRC_HUMAN
MINT-1955124   ABL1_HUMAN
MINT-3973536   NCF1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
enzyme activator activity,
protein C-terminus binding,
metal ion binding,
insulin receptor substrate binding,
calcium-independent protein kinase C activity,
ATP binding,
enzyme binding		 plasma membrane,
cytosol,
nucleus,
endoplasmic reticulum		 protein stabilization,
protein amino acid phosphorylation,
senescence,
negative regulation of insulin receptor signaling pathway,
negative regulation of peptidyl-tyrosine phosphorylation,
signal transduction,
regulation of receptor activity,
negative regulation of protein binding
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 52 KTLVQKKPTMYPEWKSTFDAH - 15302935
HTP
0.95
 Lyn SH2 C2
0.32
 1YRK 62.01%

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