a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

JAK3  Insulin R  RET  JAK2 

Substrate:	JAK3 (Cytoplasmic tyrosine kinase)
Seq-ID:	P52333 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-74564   ERBB3_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process non-membrane spanning protein tyrosine kinase activity, ATP binding, protein binding cytoskeleton, membrane, endomembrane system
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	785	RDLNSLISSDYELLSDPTPGA	-	15592455	HTP	1.00		SH2B1 SH2	-	0.28	-	-
Y	785	RDLNSLISSDYELLSDPTPGA	JAK3	15121872	LTP	1.00		SH2B1 SH2	-	0.28	-	-

Substrate:	Insulin R (Receptor tyrosine kinase)
Seq-ID:	P06213 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-16516   GRB10_HUMAN MINT-16842   MD2L1_HUMAN MINT-18199   IRS2_HUMAN MINT-19010   IRS1_HUMAN MINT-73466   GRB10_MOUSE MINT-6793537   INSR_RAT MINT-6794075   IRS1_MOUSE MINT-6794090   INSR_MOUSE MINT-6794946   PTN1_HUMAN MINT-6795115   IRS1_RAT
GO-Terms:	[show] Molecular Function Cellular Component Biological Process insulin-like growth factor receptor binding, insulin binding, PTB domain binding, GTP binding, metal ion binding, insulin receptor substrate binding, ATP binding, insulin-like growth factor I binding, insulin receptor activity, SH2 domain binding, phosphoinositide 3-kinase binding, insulin-like growth factor II binding, receptor signaling protein tyrosine kinase activity microsome, caveola, insulin receptor complex, endosome membrane positive regulation of glycolysis, positive regulation of MAPKKK cascade, positive regulation of developmental growth, regulation of embryonic development, heart morphogenesis, positive regulation of cell migration, carbohydrate metabolic process, protein heterotetramerization, positive regulation of protein kinase B signaling cascade, protein amino acid autophosphorylation, activation of MAPK activity, positive regulation of glycogen biosynthetic process, positive regulation of mitosis, peptidyl-tyrosine phosphorylation, positive regulation of glucose import, positive regulation of respiratory burst, activation of protein kinase B activity, G-protein coupled receptor protein signaling pathway, positive regulation of DNA replication, positive regulation of protein amino acid phosphorylation, positive regulation of cell proliferation, glucose homeostasis, positive regulation of nitric oxide biosynthetic process, transformation of host cell by virus, regulation of gene-specific transcription
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1185	IGDFGMTRDIYETDYYRKGGK	INSR	7806540	LTP	1.00		GRB10 SH2; GRB14 SH2; PTPN11 SH2; SH2B1 SH2; SH2B2 SH2	TyrKc	0.19	1IR3	100.87%
Y	1185	IGDFGMTRDIYETDYYRKGGK	-	18083107	HTP	1.00		GRB10 SH2; GRB14 SH2; PTPN11 SH2; SH2B1 SH2; SH2B2 SH2	TyrKc	0.19	1IR3	100.87%
Y	1189	GMTRDIYETDYYRKGGKGLLP	INSR	7806540	LTP	1.00		GRB10 SH2; GRB14 SH2; PTPN11 SH2; SH2B1 SH2; SH2B2 SH2	TyrKc	0.19	1IR3	67.69%
Y	1189	GMTRDIYETDYYRKGGKGLLP	-	9506989	LTP	1.00		GRB10 SH2; GRB14 SH2; PTPN11 SH2; SH2B1 SH2; SH2B2 SH2	TyrKc	0.19	1IR3	67.69%
Y	1189	GMTRDIYETDYYRKGGKGLLP	-	18083107	HTP	1.00		GRB10 SH2; GRB14 SH2; PTPN11 SH2; SH2B1 SH2; SH2B2 SH2	TyrKc	0.19	1IR3	67.69%
Y	1190	MTRDIYETDYYRKGGKGLLPV	INSR	7806540	LTP	1.00		GRB10 SH2; PTPN11 SH2; SH2B1 SH2	TyrKc	0.17	1IR3	44.54%
Y	1190	MTRDIYETDYYRKGGKGLLPV	-	9506989	LTP	1.00		GRB10 SH2; PTPN11 SH2; SH2B1 SH2	TyrKc	0.17	1IR3	44.54%
Y	1190	MTRDIYETDYYRKGGKGLLPV	-	18083107	HTP	1.00		GRB10 SH2; PTPN11 SH2; SH2B1 SH2	TyrKc	0.17	1IR3	44.54%

Substrate:	RET (Probable receptor with tyrosine-protein kinase activity; important for development.)
Seq-ID:	P07949 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-60970   CBL_HUMAN MINT-60975   GRB2_HUMAN MINT-60981   SHC1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process calcium ion binding, transmembrane receptor protein tyrosine kinase activity, ATP binding integral to membrane protein amino acid phosphorylation, posterior midgut development, homophilic cell adhesion
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	981	ERPDNCSEEMYRLMLQCWKQE	RET	14711813	LTP	1.00		SH2B1 SH2	TyrKc	0.34	2IVS	19.65%
Y	981	ERPDNCSEEMYRLMLQCWKQE	RET	14766744	LTP	1.00		SH2B1 SH2	TyrKc	0.34	2IVS	19.65%

Substrate:	JAK2 (Cytoplasmic tyrosine kinase)
Seq-ID:	O60674 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-13705   BRCA1_HUMAN MINT-61281   G3BP1_HUMAN MINT-74562   EGFR_HUMAN MINT-74563   ERBB3_HUMAN MINT-6764602   PTN1_HUMAN MINT-7250518   NCK1_HUMAN MINT-7251766   P85A_HUMAN MINT-7252666   PLCG1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process histone binding, Janus kinase activity, histone kinase activity (H3-Y41 specific), non-membrane spanning protein tyrosine kinase activity, ATP binding, growth hormone receptor binding, SH2 domain binding cytoskeleton, endomembrane system activation of JAK2 kinase activity, cytokine-mediated signaling pathway, cellular component movement, mesoderm development, positive regulation of tyrosine phosphorylation of Stat3 protein, positive regulation of tyrosine phosphorylation of Stat5 protein, erythrocyte differentiation, protein amino acid autophosphorylation, JAK-STAT cascade involved in growth hormone signaling pathway, response to antibiotic
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	813	RDLNSLFTPDYELLTENDMLP	-	15767667	LTP	0.95		SH2B1 SH2	-	0.28	-	-