a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

INF-alpha REC  STAT 2  IL-6R (gp130)  INF gamma R  c-kit  STAT 1 

Substrate:	INF-alpha REC (Interferon receptor)
Seq-ID:	P17181 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-73134   TYK2_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process type I interferon receptor activity integral to plasma membrane blood coagulation, JAK-STAT cascade, response to virus
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	466	AAKVFLRCINYVFFPSLKPSS	Tyk2	8605876	LTP	1.00		STAT1 SH2; STAT2 SH2; STAT3 SH2; TYK2 SH2	-	0.03	-	low
Y	466	AAKVFLRCINYVFFPSLKPSS	Tyk2	8700538	LTP	1.00		STAT1 SH2; STAT2 SH2; STAT3 SH2; TYK2 SH2	-	0.03	-	low

Substrate:	STAT 2 (Transcription factor)
Seq-ID:	P52630 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-7264052   CBP_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process calcium ion binding, hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity, sequence-specific DNA binding transcription factor activity, protein binding cytoplasm, nucleus transcription, regulation of transcription from RNA polymerase II promoter, JAK-STAT cascade, interspecies interaction between organisms, response to virus
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	690	EKVNLQERRKYLKHRLIVVSN	JAK_group	7532278	LTP	1.00		STAT1 SH2; STAT2 SH2	-	0.19	-	medium

Substrate:	IL-6R (gp130) (gp130 is shared by members of the IL-6 family)
Seq-ID:	P40189 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process ciliary neurotrophic factor receptor activity, protein homodimerization activity, interleukin-27 receptor activity, ciliary neurotrophic factor receptor binding extracellular region, oncostatin-M receptor complex, interleukin-6 receptor complex, extracellular space, ciliary neurotrophic factor receptor complex positive regulation vascular endothelial growth factor production, positive regulation of tyrosine phosphorylation of Stat3 protein, positive regulation of anti-apoptosis, leukemia inhibitory factor signaling pathway, response to cytokine stimulus, negative regulation of interleukin-6-mediated signaling pathway, positive regulation of tyrosine phosphorylation of Stat1 protein, positive regulation of adaptive immune response, ciliary neurotrophic factor-mediated signaling pathway, positive regulation of T cell proliferation, positive regulation of osteoblast differentiation, interleukin-27-mediated signaling pathway, positive regulation of acute inflammatory response, positive regulation of cardiac muscle hypertrophy
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	905	AATDEGMPKSYLPQTVRQGGY	-	8612579	LTP	1.00		STAT1 SH2; STAT3 SH2	-	0.70	-	medium
Y	905	AATDEGMPKSYLPQTVRQGGY	-	10661409	LTP	1.00		STAT1 SH2; STAT3 SH2	-	0.70	-	medium
Y	915	YLPQTVRQGGYMPQ	-	8612579	LTP	1.00		STAT1 SH2; STAT3 SH2	-	0.64	-	medium
Y	915	YLPQTVRQGGYMPQ	-	10661409	LTP	1.00		STAT1 SH2; STAT3 SH2	-	0.64	-	medium

Substrate:	INF gamma R (Interferon receptor)
Seq-ID:	P15260 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process interferon-gamma receptor activity integral to plasma membrane blood coagulation, response to virus
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	457	TVIKAPTSFGYDKPHVLVDLL	JAK1	8156998	LTP	1.00		STAT1 SH2	IFNGR1	0.37	-	low

Substrate:	c-kit (Receptor tyrosine kinase)
Seq-ID:	P10721 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process receptor signaling protein tyrosine kinase activity, ATP binding, protein binding integral to membrane, extracellular space male gonad development, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	823	LARDIKNDSNYVVKGNARLPV	-	N.N.	LTP	1.00		STAT1 SH2	TyrKc	0.18	1T46	3.93%

Substrate:	STAT 1 (Transcription factor)
Seq-ID:	P42224 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-74755   ERBB2_HUMAN MINT-7264037   CBP_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process calcium ion binding, hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity, sequence-specific DNA binding transcription factor activity, protein binding cytoplasm, nucleolus transcription from RNA polymerase II promoter, activation of caspase activity, I-kappaB kinase/NF-kappaB cascade, interspecies interaction between organisms, regulation of transcription, DNA-dependent, response to virus, tyrosine phosphorylation of STAT protein
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	701	MELDGPKGTGYIKTELISVSE	-	7592750	LTP	1.00		STAT1 SH2; STAT2 SH2	-	0.47	1BF5	139.74%
Y	701	MELDGPKGTGYIKTELISVSE	-	15322115	LTP	1.00		STAT1 SH2; STAT2 SH2	-	0.47	1BF5	139.74%
Y	701	MELDGPKGTGYIKTELISVSE	JAK2	11438544	LTP	1.00		STAT1 SH2; STAT2 SH2	-	0.47	1BF5	139.74%
Y	701	MELDGPKGTGYIKTELISVSE	JAK1	11438544	LTP	1.00		STAT1 SH2; STAT2 SH2	-	0.47	1BF5	139.74%
Y	701	MELDGPKGTGYIKTELISVSE	-	10748192	LTP	1.00		STAT1 SH2; STAT2 SH2	-	0.47	1BF5	139.74%
Y	701	MELDGPKGTGYIKTELISVSE	SRC	14978237	LTP	1.00		STAT1 SH2; STAT2 SH2	-	0.47	1BF5	139.74%
Y	701	MELDGPKGTGYIKTELISVSE	JAK2	14978237	LTP	1.00		STAT1 SH2; STAT2 SH2	-	0.47	1BF5	139.74%
Y	701	MELDGPKGTGYIKTELISVSE	JAK1	14978237	LTP	1.00		STAT1 SH2; STAT2 SH2	-	0.47	1BF5	139.74%