List of substrates found:

FCER1G  MS4A2  C-Fes  CD3 epsilon  CD3 delta  CD79A  Epo-R  Integrin beta 3  LCK  CD3 zeta  CD3 gamma 


Substrate: FCER1G (FceRI gamma)
Seq-ID: P30273 [Homo sapiens]
Download:fasta csv
Interaction Network(s):
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 65 ITSYEKSDGVYTGLSTRNQET - 18088087
HTP
1.00
FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.29
- low
Y 65 ITSYEKSDGVYTGLSTRNQET - 18083107
HTP
1.00
FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.29
- low
Y 76 TGLSTRNQETYETLKHEKPPQ - 18088087
HTP
1.00
FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.54
- low
Y 76 TGLSTRNQETYETLKHEKPPQ - 18083107
HTP
1.00
FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.54
- low

Substrate: MS4A2 (calcium channel activity)
Seq-ID: Q01362 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 219 KGNKVPEDRVYEELNIYSATY - 15339926
LTP
0.12
FES SH2;
Lyn SH2;
SHC1 SH2;
SYK SH2
-
0.21
- medium

Substrate: C-Fes (Cytoplasmic tyrosine kinase)
Seq-ID: P07332 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 811 PGQRPSFSTIYQELQSIRKRH Fes 7687763
LTP
0.23
SYK SH2 TyrKc
0.34
3BKB 31.44%

Substrate: CD3 epsilon (T cell surface glycoprotein)
Seq-ID: P07766 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 188 ERPPPVPNPDYEPIRKGQRDL - 15592455
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.67
- medium
Y 188 ERPPPVPNPDYEPIRKGQRDL - 16094384
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.67
- medium
Y 188 ERPPPVPNPDYEPIRKGQRDL - 15659558
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.67
- medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 12522270
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.40
- medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 15144186
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.40
- medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 15592455
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.40
- medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 16094384
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.40
- medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 15659558
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.40
- medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 18083107
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.40
- medium

Substrate: CD3 delta (T cell surface glycoprotein)
Seq-ID: P04234 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 149 TQALLRNDQVYQPLRDRDDAQ - 12522270
HTP
1.00
Lck SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.36
- low
Y 149 TQALLRNDQVYQPLRDRDDAQ - 15144186
HTP
1.00
Lck SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.36
- low
Y 149 TQALLRNDQVYQPLRDRDDAQ - 15592455
HTP
1.00
Lck SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.36
- low
Y 149 TQALLRNDQVYQPLRDRDDAQ - 16094384
HTP
1.00
Lck SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.36
- low
Y 149 TQALLRNDQVYQPLRDRDDAQ - 15659558
HTP
1.00
Lck SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.36
- low
Y 160 QPLRDRDDAQYSHLGGNWARN - 12522270
HTP
1.00
SYK SH2;
ZAP70 SH2
ITAM
0.38
- low
Y 160 QPLRDRDDAQYSHLGGNWARN - 15592455
HTP
1.00
SYK SH2;
ZAP70 SH2
ITAM
0.38
- low
Y 160 QPLRDRDDAQYSHLGGNWARN - 16094384
HTP
1.00
SYK SH2;
ZAP70 SH2
ITAM
0.38
- low
Y 160 QPLRDRDDAQYSHLGGNWARN - 15659558
HTP
1.00
SYK SH2;
ZAP70 SH2
ITAM
0.38
- low

Substrate: CD79A (B cell antigen receptor)
Seq-ID: P11912 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 188 AGDEYEDENLYEGLNLDDCSM Lyn 9531288
LTP
1.00
LIG_TYR_ITAM
BLK SH2;
SHC1 SH2;
SYK SH2
ITAM
0.35
- low

Substrate: Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID: P19235 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
erythropoietin receptor activity extracellular region,
integral to plasma membrane
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 368 PVGSEHAQDTYLVLDKWLLPR Lyn 10579919
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
STAT5 SH2;
SYK SH2
-
0.32
- low
Y 368 PVGSEHAQDTYLVLDKWLLPR JAK2 10579919
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
STAT5 SH2;
SYK SH2
-
0.32
- low
Y 426 PEGASAASFEYTILDPSSQLL - 10579919
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 426 PEGASAASFEYTILDPSSQLL - 12027890
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 426 PEGASAASFEYTILDPSSQLL - 12441334
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 426 PEGASAASFEYTILDPSSQLL - 10660611
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 454 ELPPTPPHLKYLYLVVSDSGI - 10579919
LTP
0.96
CISH SH2;
PTPN6 SH2;
SOCS3 SH2;
STAT5 SH2;
SYK SH2
-
0.37
- low
Y 454 ELPPTPPHLKYLYLVVSDSGI - 12027890
LTP
0.96
CISH SH2;
PTPN6 SH2;
SOCS3 SH2;
STAT5 SH2;
SYK SH2
-
0.37
- low

Substrate: Integrin beta 3 (Platelet membrane glycoprotein IIIa)
Seq-ID: P05106 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 785 EATSTFTNITYRGT        SYK 8631894
LTP
0.98
PTPN11 SH2;
SHC1 PTB;
SYK SH2
Integrin_b_cyt
0.26
--
Y 785 EATSTFTNITYRGT        SRC 8631894
LTP
0.98
PTPN11 SH2;
SHC1 PTB;
SYK SH2
Integrin_b_cyt
0.26
--
Y 785 EATSTFTNITYRGT        - 18088087
HTP
0.98
PTPN11 SH2;
SHC1 PTB;
SYK SH2
Integrin_b_cyt
0.26
--

Substrate: LCK (proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase))
Seq-ID: P06239 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 505 EDFFTATEGQYQPQP       - 3265417
LTP
0.96
Lck SH2;
Src SH2;
SYK SH2
-
0.49
--
Y 505 EDFFTATEGQYQPQP       - 15592455
HTP
0.96
Lck SH2;
Src SH2;
SYK SH2
-
0.49
--
Y 505 EDFFTATEGQYQPQP       Lck 8945479
LTP
0.96
Lck SH2;
Src SH2;
SYK SH2
-
0.49
--
Y 505 EDFFTATEGQYQPQP       - 17192257
HTP
0.96
Lck SH2;
Src SH2;
SYK SH2
-
0.49
--
Y 505 EDFFTATEGQYQPQP       - 18083107
HTP
0.96
Lck SH2;
Src SH2;
SYK SH2
-
0.49
--

Substrate: CD3 zeta (T-cell surface glycoprotein CD3 zeta chain precursor (from PhosphoBase))
Seq-ID: P20963 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 72 PAYQQGQNQLYNELNLGRREE - 15144186
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.44
- medium
Y 72 PAYQQGQNQLYNELNLGRREE - 15592455
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.44
- medium
Y 72 PAYQQGQNQLYNELNLGRREE - 16094384
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.44
- medium
Y 72 PAYQQGQNQLYNELNLGRREE - 15659558
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.44
- medium
Y 83 NELNLGRREEYDVLDKRRGRD - 12522270
HTP
1.00
Fyn SH2;
Lck SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.47
- medium
Y 83 NELNLGRREEYDVLDKRRGRD - 15592455
HTP
1.00
Fyn SH2;
Lck SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.47
- medium
Y 83 NELNLGRREEYDVLDKRRGRD - 16094384
HTP
1.00
Fyn SH2;
Lck SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.47
- medium
Y 83 NELNLGRREEYDVLDKRRGRD - 15659558
HTP
1.00
Fyn SH2;
Lck SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.47
- medium
Y 111 QRRKNPQEGLYNELQKDKMAE Fyn 8578591
LTP
1.00
LIG_TYR_ITAM
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.63
- medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 12522270
HTP
1.00
LIG_TYR_ITAM
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.63
- medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 15144186
HTP
1.00
LIG_TYR_ITAM
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.63
- medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 15592455
HTP
1.00
LIG_TYR_ITAM
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.63
- medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 16094384
HTP
1.00
LIG_TYR_ITAM
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.63
- medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 15659558
HTP
1.00
LIG_TYR_ITAM
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.63
- medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 18083107
HTP
1.00
LIG_TYR_ITAM
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.63
- medium
Y 123 ELQKDKMAEAYSEIGMKGERR Fyn 8578591
LTP
1.00
LIG_TYR_ITAM
Lck SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.49
- medium
Y 123 ELQKDKMAEAYSEIGMKGERR - 12522270
HTP
1.00
LIG_TYR_ITAM
Lck SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.49
- medium
Y 123 ELQKDKMAEAYSEIGMKGERR - 16094384
HTP
1.00
LIG_TYR_ITAM
Lck SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.49
- medium
Y 123 ELQKDKMAEAYSEIGMKGERR - 15659558
HTP
1.00
LIG_TYR_ITAM
Lck SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.49
- medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 12522270
HTP
1.00
Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.65
- medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 15592455
HTP
1.00
Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.65
- medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 16094384
HTP
1.00
Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.65
- medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 15659558
HTP
1.00
Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.65
- medium
Y 153 QGLSTATKDTYDALHMQALPP - 16094384
HTP
0.90
Fyn SH2;
Lck SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.65
- medium
Y 153 QGLSTATKDTYDALHMQALPP - 15659558
HTP
0.90
Fyn SH2;
Lck SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.65
- medium

Substrate: CD3 gamma (T-cell surface glycoprotein CD3 gamma chain (T3 gamma chain) (from PhosphoBase))
Seq-ID: P09693 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 160 KQTLLPNDQLYQPLKDREDDQ - 16094384
HTP
0.95
Lck SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.48
- low
Y 171 QPLKDREDDQYSHLQGNQLRR - 16094384
HTP
1.00
SYK SH2;
ZAP70 SH2
ITAM
0.54
- low


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