List of substrates found:

FCER1G  MS4A2  C-Fes  CD3 epsilon  CD3 delta  CD79A  Epo-R  Integrin beta 3  LCK  CD3 zeta  CD3 gamma 


Substrate: FCER1G (FceRI gamma)
Seq-ID: P30273 [Homo sapiens]
Download:fasta csv
Interaction Network(s):
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
IgE binding,
transmembrane receptor activity		 integral to plasma membrane cell surface receptor linked signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 65 ITSYEKSDGVYTGLSTRNQET - 18088087
HTP
1.00
 FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.29
 - low
Y 65 ITSYEKSDGVYTGLSTRNQET - 18083107
HTP
1.00
 FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.29
 - low
Y 76 TGLSTRNQETYETLKHEKPPQ - 18088087
HTP
1.00
 FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.54
 - low
Y 76 TGLSTRNQETYETLKHEKPPQ - 18083107
HTP
1.00
 FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.54
 - low

Substrate: MS4A2 (calcium channel activity)
Seq-ID: Q01362 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium channel activity integral to plasma membrane humoral immune response,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 219 KGNKVPEDRVYEELNIYSATY - 15339926
LTP
0.12
 FES SH2;
Lyn SH2;
SHC1 SH2;
SYK SH2		 -
0.21
 - medium

Substrate: C-Fes (Cytoplasmic tyrosine kinase)
Seq-ID: P07332 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-74535   EGFR_HUMAN
MINT-6380786   EZRI_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
protein binding		 cytosol peptidyl-tyrosine phosphorylation,
multicellular organismal development,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 811 PGQRPSFSTIYQELQSIRKRH Fes 7687763
LTP
0.23
 SYK SH2 TyrKc
0.34
 3BKB 31.44%

Substrate: CD3 epsilon (T cell surface glycoprotein)
Seq-ID: P07766 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-7213943   NCK2_HUMAN
MINT-7214058   EPS8_HUMAN
MINT-7214076   ES8L2_HUMAN
MINT-7214253   ES8L1_HUMAN
MINT-7234008   NCK1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
T cell receptor binding,
protein heterodimerization activity,
protein kinase binding,
receptor signaling complex scaffold activity,
transmembrane receptor activity,
receptor signaling protein activity		 external side of plasma membrane,
integral to plasma membrane		 signal complex assembly,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 188 ERPPPVPNPDYEPIRKGQRDL - 15592455
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.67
 - medium
Y 188 ERPPPVPNPDYEPIRKGQRDL - 16094384
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.67
 - medium
Y 188 ERPPPVPNPDYEPIRKGQRDL - 15659558
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.67
 - medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 12522270
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.40
 - medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 15144186
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.40
 - medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 15592455
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.40
 - medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 16094384
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.40
 - medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 15659558
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.40
 - medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 18083107
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.40
 - medium

Substrate: CD3 delta (T cell surface glycoprotein)
Seq-ID: P04234 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-3374054   GCR_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
transmembrane receptor activity		 cytoplasm,
integral to membrane		 positive thymic T cell selection,
cell surface receptor linked signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 149 TQALLRNDQVYQPLRDRDDAQ - 12522270
HTP
1.00
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.36
 - low
Y 149 TQALLRNDQVYQPLRDRDDAQ - 15144186
HTP
1.00
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.36
 - low
Y 149 TQALLRNDQVYQPLRDRDDAQ - 15592455
HTP
1.00
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.36
 - low
Y 149 TQALLRNDQVYQPLRDRDDAQ - 16094384
HTP
1.00
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.36
 - low
Y 149 TQALLRNDQVYQPLRDRDDAQ - 15659558
HTP
1.00
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.36
 - low
Y 160 QPLRDRDDAQYSHLGGNWARN - 12522270
HTP
1.00
 SYK SH2;
ZAP70 SH2		 ITAM
0.38
 - low
Y 160 QPLRDRDDAQYSHLGGNWARN - 15592455
HTP
1.00
 SYK SH2;
ZAP70 SH2		 ITAM
0.38
 - low
Y 160 QPLRDRDDAQYSHLGGNWARN - 16094384
HTP
1.00
 SYK SH2;
ZAP70 SH2		 ITAM
0.38
 - low
Y 160 QPLRDRDDAQYSHLGGNWARN - 15659558
HTP
1.00
 SYK SH2;
ZAP70 SH2		 ITAM
0.38
 - low

Substrate: CD79A (B cell antigen receptor)
Seq-ID: P11912 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transmembrane receptor activity B cell receptor complex,
external side of plasma membrane,
integral to membrane,
multivesicular body,
membrane raft		 B cell differentiation,
B cell receptor signaling pathway,
B cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 188 AGDEYEDENLYEGLNLDDCSM Lyn 9531288
LTP
1.00
 LIG_TYR_ITAM
 BLK SH2;
SHC1 SH2;
SYK SH2		 ITAM
0.35
 - low

Substrate: Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID: P19235 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-73504   PTN6_HUMAN
MINT-74896   PTN6_MOUSE
MINT-6794748   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
erythropoietin receptor activity extracellular region,
integral to plasma membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 368 PVGSEHAQDTYLVLDKWLLPR Lyn 10579919
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
STAT5 SH2;
SYK SH2		 -
0.32
 - low
Y 368 PVGSEHAQDTYLVLDKWLLPR JAK2 10579919
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
STAT5 SH2;
SYK SH2		 -
0.32
 - low
Y 426 PEGASAASFEYTILDPSSQLL - 10579919
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 426 PEGASAASFEYTILDPSSQLL - 12027890
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 426 PEGASAASFEYTILDPSSQLL - 12441334
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 426 PEGASAASFEYTILDPSSQLL - 10660611
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 454 ELPPTPPHLKYLYLVVSDSGI - 10579919
LTP
0.96
 CISH SH2;
PTPN6 SH2;
SOCS3 SH2;
STAT5 SH2;
SYK SH2		 -
0.37
 - low
Y 454 ELPPTPPHLKYLYLVVSDSGI - 12027890
LTP
0.96
 CISH SH2;
PTPN6 SH2;
SOCS3 SH2;
STAT5 SH2;
SYK SH2		 -
0.37
 - low

Substrate: Integrin beta 3 (Platelet membrane glycoprotein IIIa)
Seq-ID: P05106 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-25081   ITAV_HUMAN
MINT-45900   EPS8_HUMAN
MINT-45905   RBGP1_HUMAN
MINT-45913   GULP1_HUMAN
MINT-45916   RGS12_HUMAN
MINT-45923   DAB1_MOUSE
MINT-45928   DAB2_MOUSE
MINT-45939   IRS1_RAT
MINT-45952   TLN1_MOUSE
MINT-45957   JIP1_HUMAN
MINT-45960   LIN10_CAEEL
MINT-61480   TENC1_HUMAN
MINT-61568   DOK1_MOUSE
MINT-61569   NUMB_MOUSE
MINT-1795026   TLN1_HUMAN
MINT-6794817   PTN1_HUMAN
MINT-7384376   SRC_MOUSE
MINT-7384444   LYN_HUMAN
MINT-7384460   YES_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor activity,
vascular endothelial growth factor receptor 2 binding,
identical protein binding,
platelet-derived growth factor receptor binding,
cell adhesion molecule binding		 integrin complex,
alphav-beta3 integrin-vitronectin complex,
platelet alpha granule membrane		 positive regulation of peptidyl-tyrosine phosphorylation,
positive regulation of endothelial cell proliferation,
regulation of bone resorption,
blood coagulation,
negative regulation of lipid transport,
tube development,
activation of protein kinase activity,
integrin-mediated signaling pathway,
positive regulation of vascular endothelial growth factor receptor signaling pathway,
negative regulation of lipid storage,
negative regulation of macrophage derived foam cell differentiation,
cell-matrix adhesion,
interspecies interaction between organisms,
smooth muscle cell migration,
negative regulation of lipoprotein metabolic process,
angiogenesis involved in wound healing,
positive regulation of endothelial cell migration,
negative regulation of low-density lipoprotein receptor biosynthetic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 785 EATSTFTNITYRGT        SYK 8631894
LTP
0.98
 PTPN11 SH2;
SHC1 PTB;
SYK SH2		 Integrin_b_cyt
0.26
 --
Y 785 EATSTFTNITYRGT        SRC 8631894
LTP
0.98
 PTPN11 SH2;
SHC1 PTB;
SYK SH2		 Integrin_b_cyt
0.26
 --
Y 785 EATSTFTNITYRGT        - 18088087
HTP
0.98
 PTPN11 SH2;
SHC1 PTB;
SYK SH2		 Integrin_b_cyt
0.26
 --

Substrate: LCK (proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase))
Seq-ID: P06239 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15516   CBL_HUMAN
MINT-56730   KSYK_HUMAN
MINT-59474   LCP2_HUMAN
MINT-59476   ZAP70_HUMAN
MINT-60779   MK01_HUMAN
MINT-60782   CD3Z_HUMAN
MINT-61276   G3BP1_HUMAN
MINT-66002   CD4_HUMAN
MINT-66003   P85A_HUMAN
MINT-68489   DLG1_HUMAN
MINT-3373863   HS90A_HUMAN
MINT-3373920   GCR_HUMAN
MINT-7135817   SH22A_HUMAN
MINT-7212471   KHDR1_HUMAN
MINT-7212499   WASP_HUMAN
MINT-7218109   ADA15_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
protein C-terminus binding,
protein kinase binding,
protein serine/threonine phosphatase activity,
glycoprotein binding,
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
CD8 receptor binding,
ATPase binding,
CD4 receptor binding,
SH2 domain binding		 plasma membrane,
cytosol,
Golgi apparatus,
membrane raft,
pericentriolar material		 protein amino acid phosphorylation,
T cell differentiation,
response to drug,
activation of caspase activity,
positive regulation of T cell activation,
positive regulation of T cell receptor signaling pathway,
release of sequestered calcium ion into cytosol,
interspecies interaction between organisms,
cellular zinc ion homeostasis,
induction of apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 505 EDFFTATEGQYQPQP       - 3265417
LTP
0.96
 Lck SH2;
Src SH2;
SYK SH2		 -
0.49
 --
Y 505 EDFFTATEGQYQPQP       - 15592455
HTP
0.96
 Lck SH2;
Src SH2;
SYK SH2		 -
0.49
 --
Y 505 EDFFTATEGQYQPQP       Lck 8945479
LTP
0.96
 Lck SH2;
Src SH2;
SYK SH2		 -
0.49
 --
Y 505 EDFFTATEGQYQPQP       - 17192257
HTP
0.96
 Lck SH2;
Src SH2;
SYK SH2		 -
0.49
 --
Y 505 EDFFTATEGQYQPQP       - 18083107
HTP
0.96
 Lck SH2;
Src SH2;
SYK SH2		 -
0.49
 --

Substrate: CD3 zeta (T-cell surface glycoprotein CD3 zeta chain precursor (from PhosphoBase))
Seq-ID: P20963 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-60782   LCK_HUMAN
MINT-7301967   NCK1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein homodimerization activity,
transmembrane receptor activity		 cytoplasm,
integral to membrane		 interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 72 PAYQQGQNQLYNELNLGRREE - 15144186
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.44
 - medium
Y 72 PAYQQGQNQLYNELNLGRREE - 15592455
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.44
 - medium
Y 72 PAYQQGQNQLYNELNLGRREE - 16094384
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.44
 - medium
Y 72 PAYQQGQNQLYNELNLGRREE - 15659558
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.44
 - medium
Y 83 NELNLGRREEYDVLDKRRGRD - 12522270
HTP
1.00
 Fyn SH2;
Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.47
 - medium
Y 83 NELNLGRREEYDVLDKRRGRD - 15592455
HTP
1.00
 Fyn SH2;
Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.47
 - medium
Y 83 NELNLGRREEYDVLDKRRGRD - 16094384
HTP
1.00
 Fyn SH2;
Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.47
 - medium
Y 83 NELNLGRREEYDVLDKRRGRD - 15659558
HTP
1.00
 Fyn SH2;
Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.47
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE Fyn 8578591
LTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 12522270
HTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 15144186
HTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 15592455
HTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 16094384
HTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 15659558
HTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 18083107
HTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 123 ELQKDKMAEAYSEIGMKGERR Fyn 8578591
LTP
1.00
 LIG_TYR_ITAM
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.49
 - medium
Y 123 ELQKDKMAEAYSEIGMKGERR - 12522270
HTP
1.00
 LIG_TYR_ITAM
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.49
 - medium
Y 123 ELQKDKMAEAYSEIGMKGERR - 16094384
HTP
1.00
 LIG_TYR_ITAM
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.49
 - medium
Y 123 ELQKDKMAEAYSEIGMKGERR - 15659558
HTP
1.00
 LIG_TYR_ITAM
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.49
 - medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 12522270
HTP
1.00
 Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.65
 - medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 15592455
HTP
1.00
 Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.65
 - medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 16094384
HTP
1.00
 Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.65
 - medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 15659558
HTP
1.00
 Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.65
 - medium
Y 153 QGLSTATKDTYDALHMQALPP - 16094384
HTP
0.90
 Fyn SH2;
Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.65
 - medium
Y 153 QGLSTATKDTYDALHMQALPP - 15659558
HTP
0.90
 Fyn SH2;
Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.65
 - medium

Substrate: CD3 gamma (T-cell surface glycoprotein CD3 gamma chain (T3 gamma chain) (from PhosphoBase))
Seq-ID: P09693 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
T cell receptor binding,
protein heterodimerization activity,
receptor signaling complex scaffold activity,
transmembrane receptor activity		 integral to plasma membrane protein complex assembly,
T cell activation,
protein transport,
establishment or maintenance of cell polarity,
regulation of apoptosis,
cell surface receptor linked signaling pathway
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 160 KQTLLPNDQLYQPLKDREDDQ - 16094384
HTP
0.95
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.48
 - low
Y 171 QPLKDREDDQYSHLQGNQLRR - 16094384
HTP
1.00
 SYK SH2;
ZAP70 SH2		 ITAM
0.54
 - low

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