List of substrates found:

ZAP70  SH3 domain-binding protein 2  CBL E3 ubiquitin protein ligase  SLP-76  LAT  CD19 


Substrate: ZAP70 (Cytoplasmic tyrosine kinase)
Seq-ID: P43403 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-59476   LCK_HUMAN
MINT-60980   SHC1_HUMAN
MINT-74806   ERBB3_HUMAN
MINT-74807   EGFR_HUMAN
MINT-3374106   HS90A_HUMAN
MINT-3382488   LAT_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 cytosol,
T cell receptor complex		 positive thymic T cell selection,
immune response,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 11828374
LTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 7798261
LTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 12522270
HTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 15592455
HTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 16094384
HTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 10037717
LTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%

Substrate: SH3 domain-binding protein 2 (Adaptor molecule)
Seq-ID: P78314 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-17097   1433T_HUMAN
MINT-74724   ERBB2_HUMAN
MINT-4549720   VAV_HUMAN
MINT-4563345   DBNL_HUMAN
MINT-4563367   SH3K1_HUMAN
MINT-7301276   VAV2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
SH3/SH2 adaptor activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 183 DYEHDDEDDSYLEPDSPEPGR - 11390470
LTP
1.00
 PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV2 SH2;
VAV_group SH2		 -
0.89
 - medium

Substrate: CBL E3 ubiquitin protein ligase (Adaptor molecule)
Seq-ID: P22681 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15516   LCK_HUMAN
MINT-15716   CRK_HUMAN
MINT-16022   CD2AP_HUMAN
MINT-16347   LYN_HUMAN
MINT-16846   LCP2_HUMAN
MINT-17062   FCGR1_HUMAN
MINT-17932   NCK1_HUMAN
MINT-50666   FYN_HUMAN
MINT-50717   ABL1_HUMAN
MINT-50722   CRKL_HUMAN
MINT-58331   ITCH_HUMAN
MINT-60970   RET_HUMAN
MINT-60973   EGFR_HUMAN
MINT-60978   SHC1_HUMAN
MINT-68500   P85A_HUMAN
MINT-2837344   PLCG1_BOVIN
MINT-4299918   ASAP1_HUMAN
MINT-6169713   SPY1_HUMAN
MINT-6170244   SH3G2_HUMAN
MINT-6538940   SPY4_HUMAN
MINT-6538977   KSYK_HUMAN
MINT-6539587   MET_HUMAN
MINT-6539601   SPY2_HUMAN
MINT-6539646   VGFR1_HUMAN
MINT-6539679   RON_HUMAN
MINT-6539730   SRC_HUMAN
MINT-7040249   GRB2_HUMAN
MINT-7046364   ITSN1_HUMAN
MINT-7103623   MK08_HUMAN
MINT-7211864   ARHG7_HUMAN
MINT-7214822   FYN_MOUSE
MINT-7218352   SH3K1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
calcium ion binding,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
signal transducer activity,
ubiquitin-protein ligase activity		 cytosol,
nucleus		 epidermal growth factor receptor signaling pathway,
positive regulation of receptor-mediated endocytosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 700 EQCEGEEDTEYMTPSSRPLRP Fyn 9525940
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP SYK 9525940
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP Yes 9525940
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP - 9102067
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP - 12522270
HTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP INSR 11997497
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP - 10829062
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP - 15922744
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --

Substrate: SLP-76 (Adaptor molecule; involved in T cell AG receptor mediate signaling)
Seq-ID: Q13094 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-15244   FYB_HUMAN
MINT-16513   SHC1_HUMAN
MINT-16846   CBL_HUMAN
MINT-17488   FCGR1_HUMAN
MINT-59471   ITK_MOUSE
MINT-59473   ITK_HUMAN
MINT-59474   LCK_HUMAN
MINT-2837400   PLCG1_BOVIN
MINT-4302560   STAM1_HUMAN
MINT-4302608   STAM2_HUMAN
MINT-7041321   GRAP2_HUMAN
MINT-7306527   NCK1_HUMAN
MINT-7306585   SRC_CHICK
MINT-7306598   SRC_HUMAN
MINT-7306611   FYN_HUMAN
MINT-7306624   P85A_HUMAN
MINT-7306637   PLCG1_HUMAN
MINT-7306657   GRB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding cytosol immune response,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 113 GGWSSFEEDDYESPNDDQDGE - 8892604
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 9047237
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE SYK 15388330
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 12817019
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE Lck 8702662
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 8702662
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP - 8892604
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 9047237
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP SYK 15388330
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 12817019
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP Lck 8702662
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 8702662
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium

Substrate: LAT (Adaptor molecule involved in the TCR signal pathway)
Seq-ID: O54957 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity,
receptor signaling protein activity		 integral to plasma membrane,
immunological synapse		 calcium-mediated signaling,
integrin-mediated signaling pathway,
gene expression,
cellular defense response,
inflammatory response,
mast cell degranulation,
regulation of T cell activation,
Ras protein signal transduction,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 175 SAFSVESCEDYVNVPESEESA - 10811803
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
VAV_group SH2		 -
0.71
 - low
Y 175 SAFSVESCEDYVNVPESEESA ZAP70 11368773
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
VAV_group SH2		 -
0.71
 - low
Y 195 AEASLDGSREYVNVSPEQQPV - 10811803
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
VAV_group SH2		 -
0.83
 - low
Y 195 AEASLDGSREYVNVSPEQQPV ZAP70 11368773
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
VAV_group SH2		 -
0.83
 - low
Y 235 EGVDGEEAPDYENLQELN    - 10811803
LTP
1.00
 GRB2 SH2;
VAV_group SH2		 -
0.90
 - low
Y 235 EGVDGEEAPDYENLQELN    ZAP70 11368773
LTP
1.00
 GRB2 SH2;
VAV_group SH2		 -
0.90
 - low

Substrate: CD19 (Antigen of human B-lymphocytes)
Seq-ID: P15391 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor signaling protein activity,
protein binding		 integral to plasma membrane cellular defense response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 378 AAGLGGTAPSYGNPSSDVQAD - 10706702
LTP
1.00
 GRB2 SH2;
VAV_group SH2		 -
0.71
 - medium
Y 409 VGPEEEEGEGYEEPDSEEDSE - 10706702
LTP
1.00
 PLCG2 SH2;
VAV1 SH2;
VAV2 SH2;
VAV_group SH2		 -
0.97
 - medium
Y 439 QDQLSQDGSGYENPEDEPLGP - 10706702
LTP
1.00
 PLCG2 SH2;
VAV_group SH2		 -
0.97
 - medium

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