List of substrates found:


Substrate: Aurora kinase A (Serine/threonine kinase)
Seq-ID: O14965 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
protein kinase binding,
ATP binding		 spindle microtubule,
nucleus,
spindle pole centrosome		 protein amino acid phosphorylation,
cell division,
phosphoinositide-mediated signaling,
mitosis,
spindle organization,
regulation of protein stability
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 10  MDRSKENCISGPVKATAPVG Aurora A 16083426
LTP
0.45
 - -
0.75
 --
T 16 ENCISGPVKATAPVGGPKRVL Aurora A 16083426
LTP
0.13
 - -
0.65
 --
S 41 FPCQNPLPVNSGQAQRVLCPS Aurora A 16083426
LTP
0.21
 - -
0.61
 --
S 67 VPLQAQKLVSSHKPVQNQKQK Aurora A 16083426
LTP
0.06
 - -
0.70
 --
S 83 NQKQKQLQATSVPHPVSRPLN Aurora A 16083426
LTP
0.45
 - -
0.79
 --
S 98 VSRPLNNTQKSKQPLPSAPEN Aurora A 16083426
LTP
0.46
 - -
0.90
 --
S 104 NTQKSKQPLPSAPENNPEEEL Aurora A 16083426
LTP
0.27
 - -
0.89
 --
S 226 GTVYRELQKLSKFDEQRTATY Aurora A 16083426
LTP
0.08
 - S_TKc
0.21
 1MQ4 66.39%
S 266 DIKPENLLLGSAGELKIADFG Aurora A 16083426
LTP
0.30
 - S_TKc
0.13
 1MQ4 81.15%
S 278 GELKIADFGWSVHAPSSRRTT Aurora A 16083426
LTP
1.00
 - S_TKc
0.20
 1MQ4 0.00%
T 287 WSVHAPSSRRTTLCGTLDYLP Aurora A 16083426
LTP
0.35
 - S_TKc
0.25
 2J4Z 50.68%
T 288 SVHAPSSRRTTLCGTLDYLPP Aurora A 16083426
LTP
1.00
 MOD_PKA_1
 - S_TKc
0.28
 1MQ4 33.56%
S 342 NTYQETYKRISRVEFTFPDFV Aurora A 16083426
LTP
0.49
 - S_TKc
0.23
 1MQ4 23.77%
S 391 PWITANSSKPSNCQNKESASK Aurora A 16083426
LTP
0.04
 - -
0.62
 2BMC 40.98%

Substrate: Aurora kinase A (Serine/threonine kinase)
Seq-ID: Q91820 [Xenopus laevis]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
microtubule binding,
kinesin binding		 centrosome,
spindle microtubule,
spindle pole		 cell division,
peptidyl-serine phosphorylation,
protein amino acid autophosphorylation,
mitosis,
spindle assembly involved in mitosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 295 SVHAPSSRRTTLCGTLDYLPP Aurora A 14701852
LTP
1.00
 - S_TKc
0.27
 - medium

Substrate: BRCA1 (Breast cancer type 1 susceptibility protein)
Seq-ID: P38398 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13705   JAK2_HUMAN
MINT-13786   ESR1_HUMAN
MINT-14573   SMC1A_HUMAN
MINT-16089   BRAP_HUMAN
MINT-16161   P53_HUMAN
MINT-16217   CREB1_HUMAN
MINT-16582   JAK1_HUMAN
MINT-19473   FACD2_HUMAN
MINT-19477   FANCA_HUMAN
MINT-25055   BARD1_HUMAN
MINT-77954   VE7_HPV16
MINT-2490745   H4_HUMAN
MINT-2791487   RD23B_HUMAN
MINT-5115454   FANCJ_HUMAN
MINT-7213847   ABL1_HUMAN
MINT-7250578   NCK1_HUMAN
MINT-7251658   P85A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
identical protein binding,
ubiquitin protein ligase binding,
androgen receptor binding,
RNA binding,
transcription coactivator activity,
zinc ion binding,
tubulin binding,
ubiquitin-protein ligase activity		 ribonucleoprotein complex,
gamma-tubulin ring complex,
nucleoplasm,
BRCA1-BARD1 complex,
BRCA1-A complex		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
negative regulation of centriole replication,
response to estrogen stimulus,
apoptosis,
chromosome segregation,
cellular response to indole-3-methanol,
fatty acid biosynthetic process,
regulation of transcription from RNA polymerase III promoter,
cell cycle,
postreplication repair,
G2/M transition DNA damage checkpoint,
positive regulation of protein ubiquitination,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
negative regulation of transcription,
positive regulation of DNA repair,
negative regulation of fatty acid biosynthetic process,
androgen receptor signaling pathway,
regulation of cell proliferation,
protein K6-linked ubiquitination,
DNA damage response, signal transduction resulting in induction of apoptosis,
double-strand break repair via homologous recombination,
response to ionizing radiation,
protein autoubiquitination
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 308 NVEKAEFCNKSKQPGLARSQH Aurora A 14990569
LTP
1.00
 - -
0.61
 --

Substrate: cdc25B (Dual specificity phosphatase)
Seq-ID: P30305 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19329   1433Z_HUMAN
MINT-19330   1433F_HUMAN
MINT-25122   1433B_HUMAN
MINT-51069   1433S_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein tyrosine phosphatase activity,
protein binding		 cytosol,
microtubule organizing center,
nucleoplasm		 positive regulation of cell proliferation,
cell division,
protein amino acid dephosphorylation,
mitosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 353 DTPVQNKRRRSVTPPEEQQEA Aurora A 15128871
LTP
1.00
 - M-inducer_phosp
0.89
 - medium

Substrate: Centromeric protein a (DNA binding protein)
Seq-ID: P49450 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-7243462   ABL1_HUMAN
MINT-7245910   FYN_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
chromatin binding,
protein binding		 condensed nuclear chromosome kinetochore,
nucleosome		 nucleosome assembly,
kinetochore assembly,
establishment of mitotic spindle orientation,
protein localization to chromosome, centromeric region,
interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 7     MGPRRRSRKPEAPRRRS Aurora A 14667408
LTP
0.00
 - -
0.94
 - medium

Substrate: CPE-binding protein 1 (mRNA binding)
Seq-ID: P70166 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-24746   KIF1B_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
mRNA binding,
protein binding		 membrane fraction,
cell junction,
postsynaptic membrane,
cytoplasmic mRNA processing body,
postsynaptic density		 mRNA processing,
synaptonemal complex assembly,
regulation of neuronal synaptic plasticity,
regulation of translation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 171 APSVRGSRLDTRPILDSRSSS Aurora A 12815066
LTP
0.17
 - -
0.66
 - medium
T 171 APSVRGSRLDTRPILDSRSSS Aurora A 16314516
LTP
0.17
 - -
0.66
 - medium

Substrate: Cytoplasmic polyadenylation element binding protein (Unclassified)
Seq-ID: Q91572 [Xenopus laevis]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
RNA binding,
protein binding		 ribonucleoprotein complex,
spindle pole,
microtubule organizing center,
protein complex,
membrane		 mRNA processing,
regulation of translation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 174 TPLLRSSRLDSRSILDSRSSS Aurora A 14724178
LTP
0.19
 - -
0.48
 - medium

Substrate: Histone H3.1 (Histone H3)
Seq-ID: P68431 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50057   UHRF1_MOUSE
MINT-61561   GRB2_HUMAN
MINT-2829033   CBX1_HUMAN
MINT-2829698   KDM4A_HUMAN
MINT-2830038   CDYL1_HUMAN
MINT-2830062   PHF20_HUMAN
MINT-2830088   TP53B_HUMAN
MINT-2830965   CBX5_HUMAN
MINT-2831013   CBX3_HUMAN
MINT-6665460   BRD7_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
protein binding		 nucleus,
nucleosome		 nucleosome assembly
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 11 MARTKQTARKSTGGKAPRKQL Aurora A 15108802
LTP
0.87
 - -
0.78
 - medium

Substrate: Histone H3.3 (DNA binding protein)
Seq-ID: P84244 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding nucleus,
nucleosome		 nucleosome assembly
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 11 MARTKQTARKSTGGKAPRKQL Aurora A 11784863
LTP
0.76
 - -
0.79
 - low

Substrate: Methyl-CpG binding protein 3 (Transcription regulatory protein)
Seq-ID: O95983 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
protein binding		 NuRD complex transcription
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 24 GWEREEVPRRSGLSAGHRDVF Aurora A 12354758
LTP
1.00
 - MBD
0.53
 - low

Substrate: p53 (Cellular tumor antigen p53)
Seq-ID: P04637 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13742   CHK2_HUMAN
MINT-15878   UBP7_HUMAN
MINT-16161   BRCA1_HUMAN
MINT-16977   PARP1_HUMAN
MINT-19990   PIN1_HUMAN
MINT-24859   ASPP2_HUMAN
MINT-45889   CEBPZ_HUMAN
MINT-49767   ATM_HUMAN
MINT-50577   SAE1_HUMAN
MINT-56524   SP1_HUMAN
MINT-58470   MED1_HUMAN
MINT-58672   HNRL1_HUMAN
MINT-60094   HIPK2_HUMAN
MINT-61312   MK08_HUMAN
MINT-61317   WWOX_HUMAN
MINT-62206   PP1A_HUMAN
MINT-63290   ARI2_HUMAN
MINT-63365   KITH_HUMAN
MINT-63497   ZNF24_HUMAN
MINT-63537   IF2B_HUMAN
MINT-63547   RAB4A_HUMAN
MINT-63559   SAT1_HUMAN
MINT-64119   STX5_HUMAN
MINT-64188   MD2BP_HUMAN
MINT-64748   K0087_HUMAN
MINT-65132   HSPB1_HUMAN
MINT-65272   MPH6_HUMAN
MINT-68565   BMX_HUMAN
MINT-74886   NPM_HUMAN
MINT-74925   1433Z_HUMAN
MINT-1795431   NMT1_HUMAN
MINT-1891378   CDN1A_HUMAN
MINT-1958329   CHK1_HUMAN
MINT-2634790   RGRF1_HUMAN
MINT-2858243   DVL2_HUMAN
MINT-2866927   SCAM1_HUMAN
MINT-3390028   KC1D_RAT
MINT-3979604   P53_MOUSE
MINT-4049689   NR4A1_HUMAN
MINT-4052116   SYVN1_HUMAN
MINT-4052873   GRP78_HUMAN
MINT-4302642   HS71L_HUMAN
MINT-4303978   XPO1_HUMAN
MINT-4329805   TOPRS_HUMAN
MINT-4793180   EGR1_HUMAN
MINT-4793253   GSK3B_HUMAN
MINT-4793489   PML_HUMAN
MINT-5114724   ZN363_HUMAN
MINT-5207405   HDAC8_HUMAN
MINT-6540866   PSME3_HUMAN
MINT-6540889   MDM2_HUMAN
MINT-6628692   LT_SV40
MINT-6665320   CBP_HUMAN
MINT-6701342   MAP1B_HUMAN
MINT-7013631   PA1_HUMAN
MINT-7013916   RYBP_HUMAN
MINT-7103733   ANDR_HUMAN
MINT-7144912   TOE1_HUMAN
MINT-7222784   FRAP_HUMAN
MINT-7263630   EP300_HUMAN
MINT-7266250   PLK1_HUMAN
MINT-7294020   FAK1_HUMAN
MINT-7295816   IKKB_HUMAN
MINT-7557644   GRP75_HUMAN
MINT-7711943   1433S_HUMAN
MINT-7717378   PHB_HUMAN
MINT-7718917   SNAI1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription activator activity,
protease binding,
DNA strand annealing activity,
chromatin binding,
copper ion binding,
ATP binding,
transcription factor binding,
chaperone binding,
zinc ion binding,
histone acetyltransferase binding,
promoter binding,
sequence-specific DNA binding transcription factor activity,
protein N-terminus binding,
protein heterodimerization activity,
protein phosphatase 2A binding,
protein kinase binding,
ubiquitin protein ligase binding		 nucleolus,
nuclear matrix,
insoluble fraction,
protein complex,
endoplasmic reticulum,
PML body,
mitochondrion		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
senescence,
mitotic cell cycle G1/S DNA damage checkpoint,
cell cycle arrest,
regulation of mitochondrial membrane permeability,
response to gamma radiation,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
response to tumor cell,
ER overload response,
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis,
interspecies interaction between organisms,
Ras protein signal transduction,
nucleotide-excision repair,
protein tetramerization,
cellular response to glucose starvation,
negative regulation of helicase activity,
negative regulation of cell growth,
base-excision repair,
activation of caspase activity by cytochrome c,
cell aging
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 215 YLDDRNTFRHSVVVPYEPPEV Aurora A 15469940
LTP
1.00
 - P53
0.47
 3D08 6.56%
S 315 KRALPNNTSSSPQPKKKPLDG Aurora A 14702041
LTP
0.95
 PIN1 WW -
0.84
 --

Substrate: Serine/threonine-protein kinase LATS2 (Ser/Thr protein kinase family)
Seq-ID: Q9NRM7 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
MINT-1778030   JUB_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
metal ion binding,
ATP binding,
protein binding		 spindle pole,
microtubule organizing center,
nucleus		 negative regulation of cyclin-dependent protein kinase activity,
protein amino acid phosphorylation,
cell division,
G1/S transition of mitotic cell cycle,
hippo signaling cascade,
negative regulation of canonical Wnt receptor signaling pathway,
mitosis,
hormone-mediated signaling pathway,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 83 YQKALREIRYSLLPFANESGT Aurora A 15147269
LTP
0.73
 - -
0.41
 - low

Substrate: Targeting protein for Xklp2 (Cell cycle control protein)
Seq-ID: Q6NUF4 [Xenopus laevis]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding cytoplasm,
spindle pole,
nucleus,
microtubule		 cell division,
mitosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 48 ENIPPDQRRLSETSVNTEQNS Aurora A 14701852
LTP
0.07
 - Aurora-A_bind
0.88
 - low
S 90 CDVKSQSKRSSRRMSKKHRQK Aurora A 14701852
LTP
0.47
 - -
0.78
 - low
S 94 SQSKRSSRRMSKKHRQKLLVK Aurora A 14701852
LTP
0.58
 - -
0.78
 - low

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