List of substrates found:


Substrate: BMX (Tyrosine kinase)
Seq-ID: P51813 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-68564   GAB1_HUMAN
MINT-68565   P53_HUMAN
MINT-74487   EGFR_HUMAN
MINT-74488   ERBB2_HUMAN
MINT-7254948   CRK_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
metal ion binding,
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
signal transducer activity,
protein binding		 cytosol protein amino acid phosphorylation,
mesoderm development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 216 PPSSSTSLAQYDSNSKKIYGS BTK 12573241
LTP
 - - -
0.53
 - medium
Y 224 AQYDSNSKKIYGSQPNFNMQY BTK 12573241
LTP
 - STAT3 SH2 -
0.44
 - medium

Substrate: BTK (Bruton's tyrosine kinase)
Seq-ID: Q06187 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-49799   IBTK_HUMAN
MINT-59463   BLNK_MOUSE
MINT-59465   BLNK_HUMAN
MINT-7230913   ARI3A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphatidylinositol-3,4,5-trisphosphate binding,
identical protein binding,
metal ion binding,
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 plasma membrane,
cytosol,
nucleus,
membrane raft		 induction of apoptosis by extracellular signals,
calcium-mediated signaling,
mesoderm development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 223 TSELKKVVALYDYMPMNANDL BTK 8630736
LTP
1.00
 - SH3
0.28
 --
Y 551 GLSRYVLDDEYTSSVGSKFPV BTK 8630736
LTP
1.00
 - TyrKc
0.10
 1K2P 8.73%

Substrate: General transcription factor II-I (General transcription factor II-I)
Seq-ID: P78347 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-48759   NFKB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
general RNA polymerase II transcription factor activity,
sequence-specific DNA binding transcription factor activity		 cytoplasm,
nucleus		 signal transduction,
transcription initiation from RNA polymerase II promoter
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 248 TVKEESEDPDYYQYNIQAGPS BTK 11373296
LTP
0.29
 - -
0.74
 --
Y 398 PLFQSHVEDLYVEGLPEGIPF BTK 11373296
LTP
 - - GTF2I
0.29
 --
Y 503 QKFEAHPNDLYVEGLPENIPF BTK 11373296
LTP
0.16
 - GTF2I
0.31
 --

Substrate: ITK (Tyrosine kinase)
Seq-ID: Q08881 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-59473   LCP2_HUMAN
MINT-61278   G3BP1_HUMAN
MINT-74558   ERBB2_HUMAN
MINT-74559   ERBB3_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
metal ion binding,
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
protein binding		 plasma membrane,
cytosol		 protein amino acid phosphorylation,
signal transduction,
cellular defense response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 180 EPEETVVIALYDYQTNDPQEL BTK 12573241
LTP
1.00
 - SH3
0.36
 --

Substrate: PLC gamma 2 (Involved in transmembrane signaling)
Seq-ID: P16885 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-60791   Z512B_HUMAN
MINT-74685   EGFR_HUMAN
MINT-74686   ERBB2_HUMAN
MINT-7252126   P85A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide phospholipase C activity,
signal transducer activity,
protein binding		 plasma membrane phospholipid catabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 753 YNMERDINSLYDVSRMYVDPS BTK 11606584
LTP
0.37
 PLCG2 SH2 -
0.26
 - medium
Y 759 INSLYDVSRMYVDPSEINPSM BTK 11606584
LTP
0.98
 PLCG2 SH2 -
0.33
 - medium
Y 759 INSLYDVSRMYVDPSEINPSM BTK 14656219
LTP
0.98
 PLCG2 SH2 -
0.33
 - medium
Y 1197 RPVLESEEELYSSCRQLRRRQ BTK 11507089
LTP
1.00
 - -
0.33
 - medium
Y 1217 QEELNNQLFLYDTHQNLRNAN BTK 11507089
LTP
1.00
 - -
0.35
 - medium
Y 1217 QEELNNQLFLYDTHQNLRNAN BTK 17239630
LTP
1.00
 - -
0.35
 - medium

Substrate: PLC gamma 2 (Involved in transmembrane signaling)
Seq-ID: P24135 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide phospholipase C activity,
signal transducer activity,
protein binding		 membrane fraction response to magnesium ion,
response to ATP,
phospholipid catabolic process,
elevation of cytosolic calcium ion concentration
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 753 YNMERDINSLYDVSRMYVDPS BTK 11507089
LTP
0.37
 - -
0.26
 - low
Y 753 YNMERDINSLYDVSRMYVDPS BTK 11606584
LTP
0.37
 - -
0.26
 - low
Y 759 INSLYDVSRMYVDPSEINPSM BTK 11507089
LTP
0.98
 - -
0.34
 - low
Y 759 INSLYDVSRMYVDPSEINPSM BTK 11606584
LTP
0.98
 - -
0.34
 - low
Y 1197 RPVLESEEELYSSCRQLRRRQ BTK 11507089
LTP
1.00
 - -
0.33
 - low
Y 1217 QEELNNQLFLYDTHQNLRGAN BTK 11507089
LTP
1.00
 - -
0.33
 - low

Substrate: Tec (Tyrosine-protein kinase Tec (from PhosphoBase))
Seq-ID: P42680 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-74777   ERBB2_HUMAN
MINT-7145675   ASAP1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
metal ion binding,
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
protein binding		 cytoplasm protein amino acid phosphorylation,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 206 HDLRLERGQEYLILEKNDVHW BTK 12573241
LTP
0.97
 - SH3
0.28
 - medium

Substrate: WASP (Downstream effector molecule)
Seq-ID: P42768 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-13728   FGR_HUMAN
MINT-14050   ARC1B_HUMAN
MINT-14451   NCK1_HUMAN
MINT-14847   FYN_HUMAN
MINT-25018   CDC42_HUMAN
MINT-50148   PPIP1_HUMAN
MINT-50152   PTN12_HUMAN
MINT-73063   WBP4_HUMAN
MINT-7212499   LCK_HUMAN
MINT-7218827   SNX33_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding,
small GTPase regulator activity		 cytosol,
actin cytoskeleton		 epidermis development,
blood coagulation,
immune response,
defense response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 291 LTDAETSKLIYDFIEDQGGLE BTK 10068673
LTP
1.00
 - PBD
0.68
 --

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