List of substrates found:


Substrate: CD28 (Involved in T cell activation)
Seq-ID: P10747 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding,
SH3/SH2 adaptor activity,
coreceptor activity		 external side of plasma membrane,
cytosol,
integral to plasma membrane		 regulatory T cell differentiation,
humoral immune response,
positive regulation of anti-apoptosis,
regulation of defense response to virus by virus,
positive regulation of interleukin-2 biosynthetic process,
positive regulation of viral genome replication,
cell surface receptor linked signaling pathway,
cytokine biosynthetic process,
positive regulation of mitosis,
positive regulation of T cell proliferation,
positive regulation of translation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 191 SKRSRLLHSDYMNMTPRRPGP ITK 8992971
LTP
0.95
 GRAP2 SH2;
GRB2 SH2;
ITK SH2;
PIK3R1 SH2		 -
0.44
 - medium
Y 209 PGPTRKHYQPYAPPRDFAAYR ITK 8992971
LTP
1.00
 - -
0.36
 - medium
Y 218 PYAPPRDFAAYRS         ITK 8992971
LTP
0.36
 - -
0.18
 - medium

Substrate: ITK (Tyrosine kinase)
Seq-ID: Q08881 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-59473   LCP2_HUMAN
MINT-61278   G3BP1_HUMAN
MINT-74558   ERBB2_HUMAN
MINT-74559   ERBB3_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
metal ion binding,
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
protein binding		 plasma membrane,
cytosol		 protein amino acid phosphorylation,
signal transduction,
cellular defense response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 180 EPEETVVIALYDYQTNDPQEL ITK 12573241
LTP
1.00
 - SH3
0.36
 --

Substrate: SIGLEC10 (cell adhesion molecule)
Seq-ID: Q96LC7 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sugar binding plasma membrane,
extracellular region,
integral to membrane		 cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 597 RFSRHSTILDYINVVPTAGPL ITK 11733002
LTP
0.17
 - -
0.39
 - low
Y 667 ESQESQEELHYATLNFPGVRP ITK 11733002
LTP
1.00
 PTPN6 SH2 -
0.78
 - low

Substrate: Tec (Tyrosine-protein kinase Tec (from PhosphoBase))
Seq-ID: P42680 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-74777   ERBB2_HUMAN
MINT-7145675   ASAP1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
metal ion binding,
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
protein binding		 cytoplasm protein amino acid phosphorylation,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 206 HDLRLERGQEYLILEKNDVHW ITK 12573241
LTP
0.97
 - SH3
0.28
 - medium

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