List of substrates found:


Substrate: BACE1 (aspartic-type endopeptidase activity, beta-aspartyl-peptidase activity)
Seq-ID: P56817 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
beta-aspartyl-peptidase activity,
aspartic-type endopeptidase activity,
protein binding		 endosome,
integral to plasma membrane,
trans-Golgi network,
cell surface,
endoplasmic reticulum		 beta-amyloid metabolic process,
membrane protein ectodomain proteolysis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 498 QQHDDFADDISLLK        CK1_delta 11278841
LTP
0.98
 - -
0.09
 - medium

Substrate: Connexin 43 (Intercellular channel)
Seq-ID: P08050 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
MINT-1791070   ZO1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
gap junction channel activity,
PDZ domain binding		 connexon complex,
Golgi-associated vesicle membrane,
early endosome,
integral to plasma membrane,
lysosome,
fascia adherens,
mitochondrial outer membrane,
endoplasmic reticulum membrane,
multivesicular body,
membrane raft		 positive regulation of protein catabolic process,
ATP transport,
response to pH,
negative regulation of cell proliferation,
apoptosis,
vascular transport,
gap junction assembly,
protein oligomerization,
cell-cell signaling,
neuron projection morphogenesis,
regulation of calcium ion transport,
response to peptide hormone stimulus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 325 AEQNRMGQAGSTISNSHAQPF CK1_delta 12270943
LTP
0.15
 MOD_CK1_1
 - -
0.75
 --
S 328 NRMGQAGSTISNSHAQPFDFP CK1_delta 12270943
LTP
1.00
 MOD_CK1_1
 - -
0.75
 --
S 330 MGQAGSTISNSHAQPFDFPDD CK1_delta 12270943
LTP
0.22
 MOD_CK1_1
 - -
0.76
 --

Substrate: E-cadherin (Epithelial-cadherin precursor (E-cadherin) (Uvomorulin) (Cadherin-1) (CAM 120/80))
Seq-ID: P12830 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-46005   CTNB1_HUMAN
MINT-49819   PSN1_HUMAN
MINT-5224658   PVR_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription activator activity,
beta-catenin binding,
cell adhesion molecule binding,
gamma-catenin binding		 cell-cell adherens junction,
apical junction complex,
catenin complex,
lateral plasma membrane,
integral to membrane,
perinuclear region of cytoplasm,
actin cytoskeleton		 cellular response to indole-3-methanol,
positive regulation of transcription factor import into nucleus,
cellular response to lithium ion,
homophilic cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 844 DYEGSGSEAASLSSLNSSESD CK1_delta 17353278
LTP
0.98
 MOD_CK1_1
 - Cadherin_C
0.71
 - low

Substrate: Mdm2 (Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2. -) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2))
Seq-ID: P23804 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19799   ARRB1_HUMAN
MINT-7266318   PLK1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
p53 binding,
ubiquitin-protein ligase activity		 cytoplasm,
nucleolus		 traversing start control point of mitotic cell cycle,
positive regulation of cell cycle
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 238 EHSGDCLDQDSVSDQFSVEFE CK1_delta 15610030
LTP
1.00
 - -
0.51
 - medium
S 240 SGDCLDQDSVSDQFSVEFEVE CK1_delta 16055726
LTP
1.00
 MOD_GSK3_1
 - -
0.48
 - medium
S 244 LDQDSVSDQFSVEFEVESLDS CK1_delta 15610030
LTP
1.00
 - -
0.52
 - medium
S 244 LDQDSVSDQFSVEFEVESLDS CK1_delta 16055726
LTP
1.00
 - -
0.52
 - medium

Substrate: Presenilin 2 (Integral membrane protein)
Seq-ID: P49810 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13995   FLNA_HUMAN
MINT-14380   FLNB_HUMAN
MINT-14946   B2CL1_HUMAN
MINT-16271   FHL2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding centrosome,
Golgi membrane,
nuclear inner membrane,
integral to plasma membrane,
kinetochore,
endoplasmic reticulum membrane		 induction of apoptosis by extracellular signals,
membrane protein ectodomain proteolysis,
apoptosis,
Notch receptor processing,
membrane protein intracellular domain proteolysis,
positive regulation of catalytic activity,
Notch signaling pathway,
amyloid precursor protein catabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 327 LPYDPEMEEDSYDSFGEPSYP CK1_delta 9558331
LTP
0.05
 MOD_CK1_1
 - PSN
0.37
 - medium
S 330 DPEMEEDSYDSFGEPSYPEVF CK1_delta 9558331
LTP
0.14
 MOD_CK1_1
 - PSN
0.39
 - medium

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