List of substrates found:


Substrate: CD45 (Receptor tyrosine phosphatase)
Seq-ID: P08575 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase binding,
transmembrane receptor protein tyrosine phosphatase activity		 focal adhesion,
integral to plasma membrane,
membrane raft		 positive regulation of B cell proliferation,
B cell receptor signaling pathway,
regulation of S phase,
immunoglobulin biosynthetic process,
defense response to virus,
protein amino acid dephosphorylation,
positive regulation of antigen receptor-mediated signaling pathway,
release of sequestered calcium ion into cytosol,
negative regulation of T cell mediated cytotoxicity,
T cell receptor signaling pathway,
negative regulation of protein kinase activity,
B cell proliferation,
negative regulation of cytokine-mediated signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1216 RPGMVSTFEQYQFLYDVIAST Csk 7507203
LTP
1.00
 Lck SH2 PTPc
0.26
 - medium

Substrate: Fgr (Tyrosine kinase)
Seq-ID: P09769 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13728   WASP_HUMAN
MINT-56739   KSYK_HUMAN
MINT-74538   ERBB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 protein amino acid phosphorylation,
response to virus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 523 EDYFTSAEPQYQPGDQT     Csk 7515063
LTP
0.99
 MOD_TYR_CSK
 - -
0.55
 - low

Substrate: FYN (Cytoplasmic tyrosine kinase)
Seq-ID: P06241 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14847   WASP_HUMAN
MINT-15132   HNRPK_RAT
MINT-15408   KHDR1_HUMAN
MINT-15425   SHC1_HUMAN
MINT-16566   FYB_HUMAN
MINT-46000   CTNB1_MOUSE
MINT-50377   RASH_HUMAN
MINT-50652   MAP2_HUMAN
MINT-50666   CBL_HUMAN
MINT-61277   G3BP1_HUMAN
MINT-61574   CTNB1_RAT
MINT-2792095   PAK2_HUMAN
MINT-2792412   ADA15_HUMAN
MINT-2859062   ATX1_HUMAN
MINT-3381335   VGFR2_HUMAN
MINT-3381360   SRC_HUMAN
MINT-3381384   NCK1_HUMAN
MINT-4085360   TNR6_HUMAN
MINT-7214580   5HT6R_HUMAN
MINT-7245838   TRI39_HUMAN
MINT-7245886   ORC1_HUMAN
MINT-7245898   AKAP6_HUMAN
MINT-7245910   CENPA_HUMAN
MINT-7245922   LRBA_HUMAN
MINT-7245934   TRAIP_HUMAN
MINT-7245958   RPP38_HUMAN
MINT-7245970   HCN2_HUMAN
MINT-7246030   ASAP2_HUMAN
MINT-7246102   SYNJ2_HUMAN
MINT-7246150   RIMS1_HUMAN
MINT-7246210   DLGP4_HUMAN
MINT-7246222   LAP2B_HUMAN
MINT-7246246   TGON2_HUMAN
MINT-7246270   EPS15_HUMAN
MINT-7246306   CD2AP_HUMAN
MINT-7246318   MLL4_HUMAN
MINT-7246402   ARHGB_HUMAN
MINT-7246426   FLNC_HUMAN
MINT-7246450   SP1_HUMAN
MINT-7246474   RIMS2_HUMAN
MINT-7246522   ABL1_HUMAN
MINT-7246534   SNX12_HUMAN
MINT-7246558   M4K1_HUMAN
MINT-7246570   PRIC3_HUMAN
MINT-7246594   WNK2_HUMAN
MINT-7246630   RTN4_HUMAN
MINT-7246666   SF3B4_HUMAN
MINT-7246678   NFASC_HUMAN
MINT-7246714   GCF_HUMAN
MINT-7246726   PPR3D_HUMAN
MINT-7246750   BAZ2A_HUMAN
MINT-7246774   KI67_HUMAN
MINT-7246798   DDX41_HUMAN
MINT-7246810   DPOD1_HUMAN
MINT-7246834   FLNA_HUMAN
MINT-7246846   CDC27_HUMAN
MINT-7246870   SNX8_HUMAN
MINT-7246882   ABL2_HUMAN
MINT-7246918   ASAP1_HUMAN
MINT-7246930   MED14_HUMAN
MINT-7246954   WIPF1_HUMAN
MINT-7246978   E41L3_HUMAN
MINT-7247002   BCAR1_HUMAN
MINT-7247014   MYPT1_HUMAN
MINT-7247038   CAF1A_HUMAN
MINT-7247050   SHRM2_HUMAN
MINT-7247074   VP13A_HUMAN
MINT-7247086   CDKL5_HUMAN
MINT-7247098   ICAL_HUMAN
MINT-7247122   RRAS_HUMAN
MINT-7247134   NELFB_HUMAN
MINT-7247146   SPN90_HUMAN
MINT-7247158   CKAP5_HUMAN
MINT-7247170   FANCA_HUMAN
MINT-7247182   HDAC6_HUMAN
MINT-7247194   SNX3_HUMAN
MINT-7247206   BRPF3_HUMAN
MINT-7247230   XRCC1_HUMAN
MINT-7247242   DAB2_HUMAN
MINT-7247254   M4K5_HUMAN
MINT-7247290   STF1_HUMAN
MINT-7247302   DOCK1_HUMAN
MINT-7247350   BRCA2_HUMAN
MINT-7247374   RPGF1_HUMAN
MINT-7247422   DAG1_HUMAN
MINT-7247434   SUV92_HUMAN
MINT-7247446   FCG2B_HUMAN
MINT-7247458   FCG2C_HUMAN
MINT-7247482   CELR3_HUMAN
MINT-7247530   SOS1_HUMAN
MINT-7247554   MOS_HUMAN
MINT-7247566   SNX17_HUMAN
MINT-7306611   LCP2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding,
metal ion binding,
glycoprotein binding,
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 plasma membrane,
endosome,
cytosol		 learning,
feeding behavior,
calcium ion transport,
interspecies interaction between organisms,
T cell receptor signaling pathway,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 531 EDYFTATEPQYQPGENL     Csk 1985196
LTP
0.94
 MOD_TYR_CSK
 Fyn SH2;
Src SH2		 -
0.42
 --

Substrate: Src (Proto-oncogene tyrosine-protein kinase Src)
Seq-ID: P12931 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14765   DDR2_HUMAN
MINT-15459   CAV1_HUMAN
MINT-46002   CTNB1_MOUSE
MINT-50376   RASH_HUMAN
MINT-62340   KPCD_HUMAN
MINT-62342   CDCP1_HUMAN
MINT-65953   DYN1_HUMAN
MINT-65954   DYN2_HUMAN
MINT-68512   PDC6I_HUMAN
MINT-74753   ERBB3_HUMAN
MINT-2792760   PAK2_HUMAN
MINT-2793013   ADA15_HUMAN
MINT-2840132   TLR3_HUMAN
MINT-3381308   FAK1_HUMAN
MINT-3381360   FYN_HUMAN
MINT-4051815   ADRB2_HUMAN
MINT-4961196   AFAD_HUMAN
MINT-4980122   SNIP_MOUSE
MINT-5210599   SNIP_HUMAN
MINT-6539730   CBL_HUMAN
MINT-6771405   FAK1_MOUSE
MINT-6794909   ACTS_HUMAN
MINT-6795322   ACTN1_HUMAN
MINT-6795447   PTN1_HUMAN
MINT-7035260   HNRPK_HUMAN
MINT-7040283   CBLB_HUMAN
MINT-7104422   BCAR1_HUMAN
MINT-7145938   RL10_HUMAN
MINT-7244986   ASAP1_HUMAN
MINT-7244998   FANCA_HUMAN
MINT-7245022   PHAR2_HUMAN
MINT-7245034   ABL1_HUMAN
MINT-7245058   DLGP4_HUMAN
MINT-7245070   SNX17_HUMAN
MINT-7245106   RTN4_HUMAN
MINT-7245118   ASAP2_HUMAN
MINT-7245142   E41L3_HUMAN
MINT-7245154   ICAL_HUMAN
MINT-7245214   FCG2B_HUMAN
MINT-7245226   FCG2C_HUMAN
MINT-7245334   SHAN2_HUMAN
MINT-7245346   SHRM2_HUMAN
MINT-7245358   DNLI3_HUMAN
MINT-7245370   EIF3D_HUMAN
MINT-7245406   HCN2_HUMAN
MINT-7245490   CKAP5_HUMAN
MINT-7245502   M4K1_HUMAN
MINT-7245538   RPP38_HUMAN
MINT-7245562   SP1_HUMAN
MINT-7245574   DOCK1_HUMAN
MINT-7245586   RLGPB_HUMAN
MINT-7245598   ABL2_HUMAN
MINT-7245610   CELR2_HUMAN
MINT-7245622   SOS1_HUMAN
MINT-7245634   AKAP6_HUMAN
MINT-7245670   DPOD1_HUMAN
MINT-7245682   DAG1_HUMAN
MINT-7245694   SNX3_HUMAN
MINT-7245730   KI67_HUMAN
MINT-7245742   CD97_HUMAN
MINT-7245754   RPGF1_HUMAN
MINT-7245778   ACAP1_HUMAN
MINT-7245790   PRIC3_HUMAN
MINT-7245814   AKAP2_HUMAN
MINT-7245826   RRAS_HUMAN
MINT-7296136   P85A_HUMAN
MINT-7296149   ACTB_HUMAN
MINT-7306598   LCP2_HUMAN
MINT-7552515   PTPRA_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity,
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
integrin binding,
SH2 domain binding		 caveola,
cytosol		 protein amino acid phosphorylation,
regulation of bone resorption,
signal complex assembly,
regulation of vascular permeability,
response to interleukin-1,
interspecies interaction between organisms,
Ras protein signal transduction,
positive regulation of integrin activation,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 530 EDYFTSTEPQYQPGENL     Csk 12468645
LTP
0.94
 MOD_TYR_CSK
 Csk SH2;
Fyn SH2;
Lck SH2;
PIK3R1 SH2;
Src SH2		 -
0.46
 1FMK 18.34%

Substrate: Tyrosine-protein kinase Lyn (Tyr protein kinase family)
Seq-ID: P07948 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15243   SHC1_HUMAN
MINT-15994   HNRPK_RAT
MINT-16347   CBL_HUMAN
MINT-17535   KHDR1_HUMAN
MINT-17602   FAK1_HUMAN
MINT-48486   M3K3_HUMAN
MINT-50926   CIP4_HUMAN
MINT-61343   HCLS1_HUMAN
MINT-62784   CSK2B_HUMAN
MINT-2792057   PAK2_HUMAN
MINT-2792372   ADA15_HUMAN
MINT-7384444   ITB3_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor signaling protein tyrosine kinase activity,
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
protein binding		 plasma membrane,
cytosol,
Golgi apparatus,
nucleus,
perinuclear region of cytoplasm,
membrane raft		 positive regulation of cell proliferation,
response to hormone stimulus,
positive regulation of cellular component movement,
positive regulation of stress-activated protein kinase signaling cascade,
erythrocyte differentiation,
positive regulation of tyrosine phosphorylation of STAT protein,
interspecies interaction between organisms,
response to DNA damage stimulus,
peptidyl-tyrosine phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 508 DDFYTATEGQYQQQP       Csk 9171348
LTP
0.99
 MOD_TYR_CSK
 - -
0.41
 - medium

Substrate: Tyrosine-protein kinase Lyn (Tyr protein kinase family)
Seq-ID: P25911 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-58750   SKAP2_MOUSE
MINT-58751   FYB_MOUSE
MINT-58757   SRC8_MOUSE
MINT-58758   HCLS1_MOUSE
MINT-58759   BCAR1_MOUSE
MINT-58760   EFS_MOUSE
MINT-58761   IRS2_MOUSE
MINT-58762   DBNL_MOUSE
MINT-58763   DOK2_MOUSE
MINT-7137863   CRKL_HUMAN
MINT-7214337   PLCG2_MOUSE
MINT-7214388   P85A_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
erythropoietin receptor binding,
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 Golgi apparatus,
nucleus,
perinuclear region of cytoplasm		 intracellular signaling pathway,
B cell receptor signaling pathway,
hemoglobin biosynthetic process,
signal transduction,
neuron projection development,
erythrocyte differentiation,
positive regulation of tyrosine phosphorylation of STAT protein,
protein amino acid autophosphorylation,
peptidyl-tyrosine phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 508 DDFYTATEGQYQQQP       Csk 10415030
LTP
0.99
 MOD_TYR_CSK
 - -
0.42
 --

Valid HTML 4.01 Transitional