List of substrates found:


Substrate: Cyclin D1 (Cyclin D1)
Seq-ID: P25322 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
MINT-7033488   CDK4_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cyclin-dependent protein kinase regulator activity,
protein kinase binding,
protein kinase activity		 cytosol,
cyclin-dependent protein kinase holoenzyme complex,
nucleoplasm		 protein amino acid phosphorylation,
fat cell differentiation,
cell division,
mitotic cell cycle G1/S DNA damage checkpoint,
mammary gland epithelial cell proliferation,
G1/S transition of mitotic cell cycle,
negative regulation of epithelial cell differentiation,
negative regulation of Wnt receptor signaling pathway,
canonical Wnt receptor signaling pathway,
lactation,
re-entry into mitotic cell cycle,
endoplasmic reticulum unfolded protein response,
mammary gland alveolus development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 288 EEEAGLACTPTDVRDVDI    DYRK1B 15075324
LTP
1.00
 - -
0.39
 - medium

Substrate: Cyclin dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1))
Seq-ID: P46414 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cyclin-dependent protein kinase inhibitor activity cytosol,
nucleus		 negative regulation of cyclin-dependent protein kinase activity,
positive regulation of cell proliferation,
negative regulation of apoptosis,
cell cycle arrest,
cellular response to antibiotic,
cellular response to organic cyclic substance,
sensory perception of sound,
potassium ion transport,
positive regulation of microtubule polymerization,
negative regulation of cellular component movement,
negative regulation of epithelial cell proliferation involved in prostate gland development,
inner ear development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 10  MSNVRVSNGSPSLERMDARQ DYRK1B 15010468
LTP
1.00
 - -
0.74
 - medium

Substrate: DYRK1B (Dual specificity kinase)
Seq-ID: Q9Y463 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-2790102   E1A_ADE05
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
protein tyrosine kinase activity,
transcription coactivator activity		 nucleus protein amino acid phosphorylation,
positive regulation of transcription, DNA-dependent
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 271 GSSCQLGQRIYQYIQSRFYRS DYRK1B 10910078
LTP
1.00
 MOD_TYR_DYR
 - S_TKc
0.05
 - low
Y 273 SCQLGQRIYQYIQSRFYRSPE DYRK1B 10910078
LTP
1.00
 MOD_TYR_DYR
 - S_TKc
0.06
 - low

Substrate: p21 (Cyclin-dependent kinase inhibitor 1 (p21))
Seq-ID: P38936 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-50392   CC45L_HUMAN
MINT-50407   CDC6_HUMAN
MINT-50418   CDK4_HUMAN
MINT-50421   CDK6_HUMAN
MINT-50432   CCNB2_HUMAN
MINT-50437   CCND1_HUMAN
MINT-50441   CCND3_HUMAN
MINT-50445   GEMI_HUMAN
MINT-50660   CCNB1_HUMAN
MINT-73322   VE7_HPV16
MINT-73323   CDK2_HUMAN
MINT-1774121   SKP2_HUMAN
MINT-1780042   MCM7_HUMAN
MINT-1891378   P53_HUMAN
MINT-2635177   CCNE1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cyclin-dependent protein kinase inhibitor activity,
metal ion binding		 cytosol,
cyclin-dependent protein kinase holoenzyme complex,
nucleoplasm,
PCNA-p21 complex		 cellular response to extracellular stimulus,
positive regulation of fibroblast proliferation,
senescence,
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest,
negative regulation of cell proliferation,
negative regulation of cell growth,
cell cycle arrest,
G1/S transition of mitotic cell cycle,
induction of apoptosis by intracellular signals,
Ras protein signal transduction,
G2/M transition of mitotic cell cycle
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 153 RQTSMTDFYHSKRRLIFSKRK DYRK1B 15851482
LTP
0.21
 - -
0.50
 - medium

Substrate: Splicing factor 3B subunit 1 (Ribonucleoprotein)
Seq-ID: O75533 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-61826   SMAD5_HUMAN
MINT-61997   SMAD1_HUMAN
MINT-62081   SMAD9_HUMAN
MINT-62164   SNIP1_HUMAN
MINT-72780   WWOX_HUMAN
MINT-73049   WBP4_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding spliceosomal complex,
nuclear speck		 nuclear mRNA splicing, via spliceosome
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 434 IRTPARKLTATPTPLGGMTGF DYRK1B 16512921
LTP
1.00
 - SF3b1
0.68
 - medium

Substrate: TCF1 (protein binding, RNA polymerase II transcription factor acti...)
Seq-ID: P20823 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
protein homodimerization activity,
promoter binding,
sequence-specific DNA binding transcription factor activity		 cytoplasm,
nucleus		 regulation of gene-specific transcription from RNA polymerase II promoter,
glucose homeostasis,
positive regulation of transcription, DNA-dependent,
insulin secretion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 249 AECIQRGVSPSQAQGLGSNLV DYRK1B 11980910
LTP
1.00
 - HOX
0.57
 1IC8 59.84%

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