a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

Substrate:	ErbB2 (Receptor tyrosine kinase)
Seq-ID:	P04626 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-61505   P85B_HUMAN MINT-74429   ABL1_HUMAN MINT-74444   ABL2_HUMAN MINT-74462   ANS1A_HUMAN MINT-74470   APBB1_HUMAN MINT-74486   BLNK_HUMAN MINT-74488   BMX_HUMAN MINT-74498   CRK_HUMAN MINT-74502   CRKL_HUMAN MINT-74508   DAB1_HUMAN MINT-74512   DOK1_HUMAN MINT-74521   SPT6H_HUMAN MINT-74533   FER_HUMAN MINT-74538   FGR_HUMAN MINT-74540   GRAP2_HUMAN MINT-74542   GRB2_HUMAN MINT-74544   GRB7_HUMAN MINT-74553   IRS1_HUMAN MINT-74556   IRS4_HUMAN MINT-74558   ITK_HUMAN MINT-74561   JAK1_HUMAN MINT-74567   SH2B3_HUMAN MINT-74575   JIP1_HUMAN MINT-74582   MATK_HUMAN MINT-74590   NCK2_HUMAN MINT-74610   P85A_HUMAN MINT-74664   P55G_HUMAN MINT-74680   PLCG1_HUMAN MINT-74686   PLCG2_HUMAN MINT-74691   PTN11_HUMAN MINT-74712   RASA1_HUMAN MINT-74713   RIN1_HUMAN MINT-74722   SH22A_HUMAN MINT-74723   SH23A_HUMAN MINT-74724   3BP2_HUMAN MINT-74737   SHC1_HUMAN MINT-74747   SLAP1_HUMAN MINT-74755   STAT1_HUMAN MINT-74756   STAT3_HUMAN MINT-74769   KSYK_HUMAN MINT-74777   TEC_HUMAN MINT-74781   TENC1_HUMAN MINT-74786   TENS3_HUMAN MINT-74793   TLN1_HUMAN MINT-74794   TXK_HUMAN MINT-74802   VAV2_HUMAN MINT-1788719   EGFR_HUMAN MINT-1901925   LAP2_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process epidermal growth factor receptor activity, ErbB-3 class receptor binding, protein heterodimerization activity, DNA binding, protein C-terminus binding, identical protein binding, receptor signaling protein tyrosine kinase activity, ATP binding, protein phosphatase binding receptor complex, integral to membrane, nucleus, perinuclear region of cytoplasm regulation of angiogenesis, transcription, regulation of transcription, phosphoinositide 3-kinase cascade, phosphoinositide-mediated signaling, heart development, positive regulation of cell adhesion, protein amino acid autophosphorylation, positive regulation of epithelial cell proliferation, wound healing, positive regulation of MAP kinase activity, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1139	APLTCSPQPEYVNQPDVRPQP	ErbB2	11500516	LTP	1.00		GRB2 SH2; GRB7 SH2; Src SH2; STAT3 SH2	-	0.85	-	low
Y	1196	AFGGAVENPEYLTPQGGAAPQ	ErbB2	11500516	LTP	1.00		-	YLP	0.78	-	low
Y	1221	PAFSPAFDNLYYWDQDPPERG	ErbB2	11500516	LTP	0.19		GRB2 SH2; SHC1 SH2; SHC_group SH2	-	0.67	-	low
Y	1222	AFSPAFDNLYYWDQDPPERGA	ErbB2	11500516	LTP	1.00		SHC_group SH2; STAT3 SH2	-	0.68	-	low
Y	1248	KGTPTAENPEYLGLDVPV	ErbB2	11500516	LTP	1.00		MATK SH2	-	0.69	-	low