List of substrates found:


Substrate: ADAM 15 (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15)
Seq-ID: Q13444 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-2792372   LYN_HUMAN
MINT-2792392   YES_HUMAN
MINT-2792412   FYN_HUMAN
MINT-2792521   PACN3_HUMAN
MINT-2792601   ARHG7_HUMAN
MINT-2792621   ARHG6_HUMAN
MINT-2792641   NCK1_HUMAN
MINT-2792681   SRBS1_HUMAN
MINT-2792701   SH3R3_HUMAN
MINT-2792950   SNX33_HUMAN
MINT-2792970   SPD2A_HUMAN
MINT-2793013   SRC_HUMAN
MINT-7218089   HCK_HUMAN
MINT-7218109   LCK_HUMAN
MINT-7218139   GRB2_HUMAN
MINT-7218198   ABL1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
metalloendopeptidase activity,
zinc ion binding		 acrosomal vesicle,
integral to membrane,
flagellum,
adherens junction,
endomembrane system		 proteolysis,
angiogenesis,
cell-matrix adhesion,
collagen catabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 715 LLVLVMLGASYWYRARLHQRL HCK 11741929
LTP
0.30
 - TRANS
0.06
 - medium

Substrate: Bcr (Breakpoint cluster region protein)
Seq-ID: P11274 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-69534   AT2B1_HUMAN
MINT-69536   CLH1_HUMAN
MINT-69537   CFTR_HUMAN
MINT-69540   ZO2_HUMAN
MINT-69542   RGS12_HUMAN
MINT-4961172   AFAD_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Rho guanyl-nucleotide exchange factor activity,
protein serine/threonine kinase activity,
ATP binding,
GTPase activator activity		 intracellular protein amino acid phosphorylation,
signal transduction,
regulation of Rho protein signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 177 QPGADAEKPFYVNVEFHHERG HCK 16912036
LTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium

Substrate: C3G protein (Guanine nucleotide exchange factor)
Seq-ID: Q13905 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14744   GRB2_HUMAN
MINT-7244206   ABL1_HUMAN
MINT-7245754   SRC_HUMAN
MINT-7247374   FYN_HUMAN
MINT-7250842   NCK1_HUMAN
MINT-7252342   P85A_HUMAN
MINT-7254430   CRK_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
guanyl-nucleotide exchange factor activity,
SH3 domain binding		 endosome,
cytosol		 regulation of small GTPase mediated signal transduction,
transmembrane receptor protein tyrosine kinase signaling pathway,
small GTPase mediated signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 504 QSTAPIPSVPYAPFAAILPFQ HCK 14551197
LTP
0.23
 - -
0.42
 - low
Y 504 QSTAPIPSVPYAPFAAILPFQ HCK 15320955
LTP
0.23
 - -
0.42
 - low

Substrate: HCK (Tyrosine-protein kinase Hck (hemopoietic cell kinase) (from PhosphoBase))
Seq-ID: P08103 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 caveola protein amino acid phosphorylation,
defense response to Gram-positive bacterium,
phagocytosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 50 EPSANQKGPVYVPDPTSSSKL HCK 10934191
LTP
0.63
 - -
0.75
 - medium
Y 409 GLARIIEDNEYTAREGAKFPI HCK 10934191
LTP
0.89
 - TyrKc
0.17
 - medium

Substrate: HCK (Tyrosine-protein kinase Hck (hemopoietic cell kinase) (from PhosphoBase))
Seq-ID: P08631 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-74550   ERBB3_HUMAN
MINT-2792779   PAK2_HUMAN
MINT-7051501   KHDR1_HUMAN
MINT-7051548   SOS1_HUMAN
MINT-7145752   ASAP1_HUMAN
MINT-7218089   ADA15_HUMAN
MINT-7232904   ABL1_HUMAN
MINT-7302799   RUFY1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
protein binding		 cytoplasm,
caveola		 protein amino acid phosphorylation,
mesoderm development,
interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 209 KIRTLDNGGFYISPRSTFSTL HCK 10644735
LTP
0.95
 - SH2
0.25
 1QCF 11.35%
Y 411 GLARVIEDNEYTAREGAKFPI HCK 10644735
LTP
0.83
 - TyrKc
0.19
 1QCF 7.42%
Y 522 DDFYTATESQYQQQP       HCK 10644735
LTP
0.92
 - -
0.47
 1QCF 13.10%
Y 522 DDFYTATESQYQQQP       HCK 10644735
LTP
0.92
 - -
0.47
 1QCF 13.10%

Substrate: LAMP (Unclassified)
Seq-ID: Q91GT2 [Human herpesvirus 8]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 480 QAATQPTDDLYEEVLFPRN   HCK 12915550
LTP
 - - Herpes_LAMP2
0.68
 - low

Substrate: STAT 5B (Transcription factor)
Seq-ID: P51692 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-58270   STAP2_HUMAN
MINT-61490   EGFR_HUMAN
MINT-61524   ERBB4_HUMAN
MINT-6794005   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
glucocorticoid receptor binding,
calcium ion binding,
sequence-specific DNA binding transcription factor activity		 nucleus valine metabolic process,
oxaloacetate metabolic process,
creatinine metabolic process,
isoleucine metabolic process,
taurine metabolic process,
response to estradiol stimulus,
allantoin metabolic process,
fatty acid metabolic process,
citrate metabolic process,
JAK-STAT cascade involved in growth hormone signaling pathway,
2-oxoglutarate metabolic process,
succinate metabolic process,
creatine metabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 699 ESATAKAVDGYVKPQIKQVVP HCK 12411494
LTP
0.05
 STAT5 SH2 SH2
0.32
 - medium

Substrate: WASP (Downstream effector molecule)
Seq-ID: P42768 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-13728   FGR_HUMAN
MINT-14050   ARC1B_HUMAN
MINT-14451   NCK1_HUMAN
MINT-14847   FYN_HUMAN
MINT-25018   CDC42_HUMAN
MINT-50148   PPIP1_HUMAN
MINT-50152   PTN12_HUMAN
MINT-73063   WBP4_HUMAN
MINT-7212499   LCK_HUMAN
MINT-7218827   SNX33_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding,
small GTPase regulator activity		 cytosol,
actin cytoskeleton		 epidermis development,
blood coagulation,
immune response,
defense response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 291 LTDAETSKLIYDFIEDQGGLE HCK 12235133
LTP
1.00
 - PBD
0.68
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