List of substrates found:


Substrate: CBX4 (Enzyme: ligase)
Seq-ID: O00257 [Homo sapiens]
Download:fasta csv
Interaction Network(s):
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-4543739   CBX8_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription corepressor activity,
enzyme binding		 chromatin,
Golgi apparatus,
nucleus		 chromatin modification,
transcription,
anti-apoptosis,
chromatin assembly or disassembly
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 495 PPSSLQVKPETPASAAVAVAA HIPK2 17018294
LTP
0.00
 - -
0.60
 - medium

Substrate: p53 (Cellular tumor antigen p53)
Seq-ID: P04637 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13742   CHK2_HUMAN
MINT-15878   UBP7_HUMAN
MINT-16161   BRCA1_HUMAN
MINT-16977   PARP1_HUMAN
MINT-19990   PIN1_HUMAN
MINT-24859   ASPP2_HUMAN
MINT-45889   CEBPZ_HUMAN
MINT-49767   ATM_HUMAN
MINT-50577   SAE1_HUMAN
MINT-56524   SP1_HUMAN
MINT-58470   MED1_HUMAN
MINT-58672   HNRL1_HUMAN
MINT-60094   HIPK2_HUMAN
MINT-61312   MK08_HUMAN
MINT-61317   WWOX_HUMAN
MINT-62206   PP1A_HUMAN
MINT-63290   ARI2_HUMAN
MINT-63365   KITH_HUMAN
MINT-63497   ZNF24_HUMAN
MINT-63537   IF2B_HUMAN
MINT-63547   RAB4A_HUMAN
MINT-63559   SAT1_HUMAN
MINT-64119   STX5_HUMAN
MINT-64188   MD2BP_HUMAN
MINT-64748   K0087_HUMAN
MINT-65132   HSPB1_HUMAN
MINT-65272   MPH6_HUMAN
MINT-68565   BMX_HUMAN
MINT-74886   NPM_HUMAN
MINT-74925   1433Z_HUMAN
MINT-1795431   NMT1_HUMAN
MINT-1891378   CDN1A_HUMAN
MINT-1958329   CHK1_HUMAN
MINT-2634790   RGRF1_HUMAN
MINT-2858243   DVL2_HUMAN
MINT-2866927   SCAM1_HUMAN
MINT-3390028   KC1D_RAT
MINT-3979604   P53_MOUSE
MINT-4049689   NR4A1_HUMAN
MINT-4052116   SYVN1_HUMAN
MINT-4052873   GRP78_HUMAN
MINT-4302642   HS71L_HUMAN
MINT-4303978   XPO1_HUMAN
MINT-4329805   TOPRS_HUMAN
MINT-4793180   EGR1_HUMAN
MINT-4793253   GSK3B_HUMAN
MINT-4793489   PML_HUMAN
MINT-5114724   ZN363_HUMAN
MINT-5207405   HDAC8_HUMAN
MINT-6540866   PSME3_HUMAN
MINT-6540889   MDM2_HUMAN
MINT-6628692   LT_SV40
MINT-6665320   CBP_HUMAN
MINT-6701342   MAP1B_HUMAN
MINT-7013631   PA1_HUMAN
MINT-7013916   RYBP_HUMAN
MINT-7103733   ANDR_HUMAN
MINT-7144912   TOE1_HUMAN
MINT-7222784   FRAP_HUMAN
MINT-7263630   EP300_HUMAN
MINT-7266250   PLK1_HUMAN
MINT-7294020   FAK1_HUMAN
MINT-7295816   IKKB_HUMAN
MINT-7557644   GRP75_HUMAN
MINT-7711943   1433S_HUMAN
MINT-7717378   PHB_HUMAN
MINT-7718917   SNAI1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription activator activity,
protease binding,
DNA strand annealing activity,
chromatin binding,
copper ion binding,
ATP binding,
transcription factor binding,
chaperone binding,
zinc ion binding,
histone acetyltransferase binding,
promoter binding,
sequence-specific DNA binding transcription factor activity,
protein N-terminus binding,
protein heterodimerization activity,
protein phosphatase 2A binding,
protein kinase binding,
ubiquitin protein ligase binding		 nucleolus,
nuclear matrix,
insoluble fraction,
protein complex,
endoplasmic reticulum,
PML body,
mitochondrion		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
senescence,
mitotic cell cycle G1/S DNA damage checkpoint,
cell cycle arrest,
regulation of mitochondrial membrane permeability,
response to gamma radiation,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
response to tumor cell,
ER overload response,
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis,
interspecies interaction between organisms,
Ras protein signal transduction,
nucleotide-excision repair,
protein tetramerization,
cellular response to glucose starvation,
negative regulation of helicase activity,
negative regulation of cell growth,
base-excision repair,
activation of caspase activity by cytochrome c,
cell aging
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 46 PSQAMDDLMLSPDDIEQWFTE HIPK2 16729035
LTP
0.58
 MAGI1 WW;
PIN1 WW		 -
0.63
 --
S 46 PSQAMDDLMLSPDDIEQWFTE HIPK2 11780126
LTP
0.58
 MAGI1 WW;
PIN1 WW		 -
0.63
 --

Substrate: PAX6 (Transcription factor)
Seq-ID: P63015 [Mus musculus]
Download:fasta csv
Interaction Network(s):
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
promoter binding,
sequence-specific DNA binding transcription factor activity,
protein binding		 transcription factor complex axon guidance,
dorsal/ventral axis specification,
transcription,
regulation of cell migration,
astrocyte differentiation,
keratinocyte differentiation,
negative regulation of epithelial cell proliferation,
protein localization in organelle,
regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification,
eye photoreceptor cell development,
regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification,
positive regulation of neuroblast proliferation,
forebrain anterior/posterior pattern formation,
oligodendrocyte cell fate specification,
forebrain-midbrain boundary formation,
smoothened signaling pathway,
negative regulation of neuron differentiation,
regulation of timing of cell differentiation,
positive regulation of epithelial cell differentiation,
neuron migration,
forebrain dorsal/ventral pattern formation,
pallium development,
commitment of a neuronal cell to a specific type of neuron in the forebrain,
cell fate determination,
pituitary gland development,
positive regulation of transcription from RNA polymerase II promoter,
regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment,
lacrimal gland development,
lens development in camera-type eye,
salivary gland morphogenesis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 281 LRNQRRQASNTPSHIPISSSF HIPK2 16407227
LTP
0.13
 - -
0.75
 --
T 304 SVYQPIPQPTTPVSSFTSGSM HIPK2 16407227
LTP
0.25
 - -
0.63
 --
T 373 SVNGRSYDTYTPPHMQTHMNS HIPK2 16407227
LTP
0.26
 - -
0.77
 --

Substrate: PML (protein binding)
Seq-ID: P29590 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-4793330   MDM2_HUMAN
MINT-4793489   P53_HUMAN
MINT-6743913   TOP3A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
DNA binding,
protein homodimerization activity,
ubiquitin protein ligase binding,
transcription coactivator activity,
zinc ion binding,
protein binding,
transcription repressor activity,
cobalt ion binding		 cytoplasm,
nuclear membrane,
nucleolus,
nuclear matrix,
insoluble fraction,
nucleus,
PML body		 protein stabilization,
negative regulation of angiogenesis,
negative regulation of cell proliferation,
negative regulation of cell growth,
cell cycle arrest,
positive regulation of histone deacetylation,
negative regulation of transcription,
PML body organization,
response to cytokine stimulus,
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis,
interspecies interaction between organisms,
protein targeting,
maintenance of protein location in nucleus,
negative regulation of mitotic cell cycle,
induction of apoptosis,
DNA damage response, signal transduction resulting in induction of apoptosis,
negative regulation of translation in response to oxidative stress,
positive regulation of defense response to virus by host,
protein complex assembly,
transcription,
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest,
response to hypoxia
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 38 TPSEGRQPSPSPSPTERAPAS HIPK2 19015637
LTP
1.00
 - -
0.95
 - medium

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