List of substrates found:


Substrate: IKB-alpha (Major histocompatibility complex enhancer-binding protein MAD3)
Seq-ID: Q9Z1E3 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-19530   TF65_MOUSE
MINT-50016   TF65_HUMAN
MINT-50067   KAPCA_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytosol,
nucleus		 negative regulation of myeloid cell differentiation,
negative regulation of Notch signaling pathway,
lipopolysaccharide-mediated signaling pathway,
response to exogenous dsRNA,
nucleotide-binding oligomerization domain containing 2 signaling pathway,
regulation of cell proliferation,
nucleotide-binding oligomerization domain containing 1 signaling pathway,
protein import into nucleus, translocation,
response to muramyl dipeptide,
toll-like receptor 4 signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 32 KERLVDDRHDSGLDSMKDEEY IKK_epsilon 10421793
LTP
1.00
 - -
0.65
 - medium
S 36 VDDRHDSGLDSMKDEEYEQMV IKK_epsilon 10421793
LTP
1.00
 - -
0.65
 - medium

Substrate: IKBKE (ATP binding, NF-kappaB-inducing kinase activity)
Seq-ID: Q9R0T8 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
NF-kappaB-inducing kinase activity,
IkappaB kinase activity,
ATP binding		 cytoplasm,
PML body		 protein amino acid phosphorylation,
positive regulation of I-kappaB kinase/NF-kappaB cascade,
DNA damage response, signal transduction resulting in induction of apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 172 RKLDDDEKFVSVYGTEEYLHP IKK_epsilon 10421793
LTP
1.00
 - STYKc
0.28
 - medium

Substrate: IRF3 (Transcription factor)
Seq-ID: Q14653 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-6540731   CBP_HUMAN
MINT-6948128   TBK1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
RNA polymerase II transcription factor activity,
transcription cofactor activity,
sequence-specific DNA binding transcription factor activity		 cytosol,
nucleoplasm,
endosome membrane		 transcription from RNA polymerase II promoter,
I-kappaB kinase/NF-kappaB cascade,
interspecies interaction between organisms,
regulation of transcription, DNA-dependent,
response to virus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 386 VEMARVGGASSLENTVDLHIS IKK_epsilon 14703513
LTP
0.99
 - -
0.35
 1QWT 111.48%

Substrate: p65 (Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit), RelA)
Seq-ID: Q04206 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50016   IKBA_MOUSE
MINT-50017   IKBB_MOUSE
MINT-50025   KAPCA_HUMAN
MINT-50073   KS6A5_HUMAN
MINT-50084   KPCZ_HUMAN
MINT-50090   CSK21_HUMAN
MINT-50107   IKKA_HUMAN
MINT-50167   IKKB_HUMAN
MINT-50171   HDAC1_HUMAN
MINT-50175   KAT2B_HUMAN
MINT-50178   EP300_HUMAN
MINT-50179   HDAC3_HUMAN
MINT-58638   NCF1_HUMAN
MINT-62399   TF2B_HUMAN
MINT-2834593   NCOA3_HUMAN
MINT-6166971   OGT1_HUMAN
MINT-7235700   ASPP2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription repressor activity,
transcription repressor binding,
identical protein binding,
protein kinase binding,
ubiquitin protein ligase binding,
transcription activator binding,
transcription activator activity,
RNA polymerase II transcription factor activity, enhancer binding,
promoter binding,
protein N-terminus binding,
phosphate binding,
NF-kappaB binding		 cytosol,
transcription factor complex		 transcription,
positive regulation of I-kappaB kinase/NF-kappaB cascade,
cytokine-mediated signaling pathway,
anti-apoptosis,
defense response to virus,
membrane protein intracellular domain proteolysis,
cellular defense response,
inflammatory response,
nucleotide-binding oligomerization domain containing 2 signaling pathway,
response to interleukin-1,
interspecies interaction between organisms,
positive regulation of NF-kappaB transcription factor activity,
positive regulation of transcription from RNA polymerase II promoter,
response to UV-B,
negative regulation of gene-specific transcription
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 536 GLLSGDEDFSSIADMDFSALL IKK_epsilon 15489227
LTP
0.93
 - -
0.35
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