a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

Substrate:	IRAK1 (Interleukin-1 receptor-associated kinase 1)
Seq-ID:	P51617 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-49176   TAB1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process NF-kappaB-inducing kinase activity, protein heterodimerization activity, protein homodimerization activity, transcription activator activity, ATP binding, protein binding cytosol, interleukin-1 receptor complex negative regulation of NF-kappaB transcription factor activity, regulation of cytokine-mediated signaling pathway, activation of NF-kappaB-inducing kinase activity, anti-apoptosis, lipopolysaccharide-mediated signaling pathway, protein oligomerization, protein amino acid autophosphorylation, transmembrane receptor protein serine/threonine kinase signaling pathway, response to interleukin-1, positive regulation of NF-kappaB transcription factor activity, toll-like receptor 2 signaling pathway, MyD88-dependent toll-like receptor signaling pathway, interleukin-1-mediated signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	209	CWPLCEISRGTHNFSEELKIG	IRAK1	14625308	LTP	1.00		-	-	0.22	-	low
T	387	MVARTQTVRGTLAYLPEEYIK	IRAK1	14625308	LTP	1.00		-	STYKc	0.29	-	low

Substrate:	STAT 3 (Transcription factor)
Seq-ID:	P40763 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-74756   ERBB2_HUMAN MINT-6764613   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein dimerization activity, calcium ion binding, hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity, protein kinase binding, transcription activator activity, transcription factor binding, sequence-specific DNA binding transcription factor activity plasma membrane, cytoplasm, nucleus interleukin-6-mediated signaling pathway, eating behavior, glucose homeostasis, cellular component movement, response to estradiol stimulus, temperature homeostasis, interspecies interaction between organisms, JAK-STAT cascade involved in growth hormone signaling pathway, sexual reproduction, eye photoreceptor cell differentiation, negative regulation of transcription from RNA polymerase II promoter
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	727	TCSNTIDLPMSPRTLDSLMQF	IRAK1	15465816	LTP	0.75		-	-	0.45	-	-