Phospho.ELM Result

a database of S/T/Y phosphorylation sites

IRAK1 (Interleukin-1 receptor-associated kinase 1)

Seq-ID:

P51617 [Homo sapiens]

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Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

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Molecular Function	Cellular Component	Biological Process
NF-kappaB-inducing kinase activity, protein heterodimerization activity, protein homodimerization activity, transcription activator activity, ATP binding, protein binding	cytosol, interleukin-1 receptor complex	negative regulation of NF-kappaB transcription factor activity, regulation of cytokine-mediated signaling pathway, activation of NF-kappaB-inducing kinase activity, anti-apoptosis, lipopolysaccharide-mediated signaling pathway, protein oligomerization, protein amino acid autophosphorylation, transmembrane receptor protein serine/threonine kinase signaling pathway, response to interleukin-1, positive regulation of NF-kappaB transcription factor activity, toll-like receptor 2 signaling pathway, MyD88-dependent toll-like receptor signaling pathway, interleukin-1-mediated signaling pathway

Conservation:

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Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	100	LQLLRARDIITAWHPPAPLPS	PKB_group	11976320	LTP	0.05	-	Death	0.38	-	low
T	209	CWPLCEISRGTHNFSEELKIG	IRAK1	14625308	LTP	1.00	-	-	0.22	-	low
S	371	LARFSRFAGSSPSQSSMVART	-	18669648	HTP	0.92	-	STYKc	0.31	-	low
S	376	RFAGSSPSQSSMVARTQTVRG	IRAK4	11960013	LTP	1.00	-	STYKc	0.44	-	low
T	387	MVARTQTVRGTLAYLPEEYIK	IRAK4	11960013	LTP	1.00	-	STYKc	0.29	-	low
T	387	MVARTQTVRGTLAYLPEEYIK	IRAK1	14625308	LTP	1.00	-	STYKc	0.29	-	low
S	568	AAPWQPLAAPSGASAQAAEQL	-	16094384	HTP	0.93	-	-	0.68	-	low