Click on substrate name for additional information.


Substrate: IRAK1 (Interleukin-1 receptor-associated kinase 1)
Seq-ID: P51617 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-49176   TAB1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
NF-kappaB-inducing kinase activity,
protein heterodimerization activity,
protein homodimerization activity,
transcription activator activity,
ATP binding,
protein binding		 cytosol,
interleukin-1 receptor complex		 negative regulation of NF-kappaB transcription factor activity,
regulation of cytokine-mediated signaling pathway,
activation of NF-kappaB-inducing kinase activity,
anti-apoptosis,
lipopolysaccharide-mediated signaling pathway,
protein oligomerization,
protein amino acid autophosphorylation,
transmembrane receptor protein serine/threonine kinase signaling pathway,
response to interleukin-1,
positive regulation of NF-kappaB transcription factor activity,
toll-like receptor 2 signaling pathway,
MyD88-dependent toll-like receptor signaling pathway,
interleukin-1-mediated signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 376 RFAGSSPSQSSMVARTQTVRG IRAK4 11960013
LTP
1.00
 - STYKc
0.44
 - low
T 387 MVARTQTVRGTLAYLPEEYIK IRAK4 11960013
LTP
1.00
 - STYKc
0.29
 - low

Valid HTML 4.01 Transitional